CMN 548 UNIT 5 EXAM QUESTIONS
WITH COMPLETE SOLUTIONS
2025/2026
,Partial or Mixed Agonist - ANSWERSA compound that elicits a partial pharmacological
response at the receptor site involved
Remission - ANSWERSThe degree of improvement to below the syndromal threshold of
a disorder
Paradoxical - ANSWERSA response to a drug that represents the clinical effect
opposite of what is expected
Inverse agonist - ANSWERSAn agent that binds to the same receptor site as an agonist
but produces the opposite pharmacological effect
4 major transmitters - ANSWERSDopamine, Serotonin, GABA, Norepinephrine
Dopamine transmitter affects? - ANSWERSaffects mood, Psychosis, ADHD, Addiction
Potency - ANSWERSrefers to the relative dose required to achieve certain effects, not
to the efficacy of a drug
Agonist (full agonist) - ANSWERSA drug that binds to a specific receptor producing an
effect identical to that usually produced by the neurotransmitter affecting that receptor
Pharmacodynamics - ANSWERSThe time course and intensity of a drug's effect/what
the drug does to the body
Pharmacokinetics - ANSWERSWhat the body does to a drug
Tolerance - ANSWERSDevelops over time a need to use increased doses of a
medication/drug to maintain a clinical effect. Or, a decreased sensitivity to adverse
effects of a drug
Stevens-Johnson Syndrome - ANSWERSA systemic, immune-mediated reaction that
can be fatal or result in permanent scarring or blindness
Antagonist - ANSWERSA compound that blinds to a receptor that blocks or reduces the
action of another substance at the receptor site
Hyponatremia - ANSWERSCommon symptoms of this medication side effect include
confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
Therapeutic index - ANSWERSratio of the median toxic dose to the median effective
dose
, Somnolence - ANSWERSDaytime sleepiness
Black Box Warning - ANSWERSThis warning reflects that a medication may cause a
serious or even life-threatening side effect
Serotonin transmitter affects? - ANSWERSDepression, aggression, OCD, Panic, GAD,
Social Anxiety, PTSD, Violence, Sexual dysfunction, substance addiction
Norepinephrine affects? - ANSWERSAffects mood, anxiety, psychosis, ADHD (part),
drug withdrawal
GABA affects? - ANSWERSFear, anxiety, worry
Irreversible MAOIs Types - ANSWERSMAOa and MAOb
Irreversible MAOIs medications - ANSWERSPhenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of MAO for how long? -
ANSWERSbecause they irreversibly inactivate MAOs, the therapeutic effect of a single
dose of irreversible MAOIs may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - ANSWERSorthostatic
hypotension, insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - ANSWERSMoclobemide (Maerix)
How long will it take to recover MAO activity after a final dose of RIMA? -
ANSWERSMAO activity recovers completely 24-48 hrs after the last dose of a RIMA
MAOIs are used to treat what conditions? - ANSWERSdepression
panic disorder
social phobia
bulimia nervosa
ptsd
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
Treatment for MAOI induced orthostatic hypotension? - ANSWERSAvoid caffeine
WITH COMPLETE SOLUTIONS
2025/2026
,Partial or Mixed Agonist - ANSWERSA compound that elicits a partial pharmacological
response at the receptor site involved
Remission - ANSWERSThe degree of improvement to below the syndromal threshold of
a disorder
Paradoxical - ANSWERSA response to a drug that represents the clinical effect
opposite of what is expected
Inverse agonist - ANSWERSAn agent that binds to the same receptor site as an agonist
but produces the opposite pharmacological effect
4 major transmitters - ANSWERSDopamine, Serotonin, GABA, Norepinephrine
Dopamine transmitter affects? - ANSWERSaffects mood, Psychosis, ADHD, Addiction
Potency - ANSWERSrefers to the relative dose required to achieve certain effects, not
to the efficacy of a drug
Agonist (full agonist) - ANSWERSA drug that binds to a specific receptor producing an
effect identical to that usually produced by the neurotransmitter affecting that receptor
Pharmacodynamics - ANSWERSThe time course and intensity of a drug's effect/what
the drug does to the body
Pharmacokinetics - ANSWERSWhat the body does to a drug
Tolerance - ANSWERSDevelops over time a need to use increased doses of a
medication/drug to maintain a clinical effect. Or, a decreased sensitivity to adverse
effects of a drug
Stevens-Johnson Syndrome - ANSWERSA systemic, immune-mediated reaction that
can be fatal or result in permanent scarring or blindness
Antagonist - ANSWERSA compound that blinds to a receptor that blocks or reduces the
action of another substance at the receptor site
Hyponatremia - ANSWERSCommon symptoms of this medication side effect include
confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
Therapeutic index - ANSWERSratio of the median toxic dose to the median effective
dose
, Somnolence - ANSWERSDaytime sleepiness
Black Box Warning - ANSWERSThis warning reflects that a medication may cause a
serious or even life-threatening side effect
Serotonin transmitter affects? - ANSWERSDepression, aggression, OCD, Panic, GAD,
Social Anxiety, PTSD, Violence, Sexual dysfunction, substance addiction
Norepinephrine affects? - ANSWERSAffects mood, anxiety, psychosis, ADHD (part),
drug withdrawal
GABA affects? - ANSWERSFear, anxiety, worry
Irreversible MAOIs Types - ANSWERSMAOa and MAOb
Irreversible MAOIs medications - ANSWERSPhenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
A single dose of MAOIs may persist in its inhibition of MAO for how long? -
ANSWERSbecause they irreversibly inactivate MAOs, the therapeutic effect of a single
dose of irreversible MAOIs may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - ANSWERSorthostatic
hypotension, insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - ANSWERSMoclobemide (Maerix)
How long will it take to recover MAO activity after a final dose of RIMA? -
ANSWERSMAO activity recovers completely 24-48 hrs after the last dose of a RIMA
MAOIs are used to treat what conditions? - ANSWERSdepression
panic disorder
social phobia
bulimia nervosa
ptsd
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
Treatment for MAOI induced orthostatic hypotension? - ANSWERSAvoid caffeine
