questions with answers |\ |\
Lacrimation (B) and piloerection (C) are clinical |\ |\ |\ |\ |\ |\ |\
manifestations associated with ________withdrawal. |\ |\ |\
opioid
withdrawal include gastrointestinal distress (abdominal cramps,
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diarrhea, nausea, and vomiting), flu-like symptoms (rhinorrhea,
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diaphoresis, and shivering), sympathetic and central nervous
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system arousal (mydriasis, mild hypertension and tachycardia,
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anxiety and irritability, insomnia, agitation, restless legs
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syndrome, general restlessness, and tremor), yawning, sneezing,
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anorexia, dizziness, myalgias, and leg cramp
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Lithium causes __?__. |\ |\
Kidney issue or hepatic issue?
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Lithium is classically known to cause a decline in kidney
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function over time. The risk factors for this decline include
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prolonged use, higher serum concentrations, older age, medical
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comorbidities, and a lower baseline glomerular filtration rate. The |\ |\ |\ |\ |\ |\ |\ |\
other adverse effects of lithium include nausea, tremor,
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polyuria, thirst, loose stools, weight gain, and cognitive
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impairment. Lithium can also adversely affect the thyroid gland
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over time. Patients who are treated with lithium should have their
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blood urea nitrogen and creatinine checked every 2 months for
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the first 6 months and then every 6–12 months thereafter.
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Valproate can cause hepatotoxicity and is avoided in women of
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childbearing age due to teratogenicity. |\ |\ |\ |\
,Question: Which medications are known to increase lithium
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levels? |\
Answer:
Angiotensin-converting enzyme inhibitors, |\ |\
nonsteroidal anti-inflammatory drugs, |\ |\
thiazide diuretics, |\
tetracycline,
metronidazole.
What is the mechanism of action of methylphenidate?
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Answer: Blocks reuptake of dopamine and norepinephrine.
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MOA of amphetamine?
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Block reuptake of NE/DA, also causes the NE/DA reuptake
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transporters to work in reverse, releasing more NT into the cleft.
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.
Amphetamines are lipophilic compounds that readily cross the |\ |\ |\ |\ |\ |\ |\ |\
blood-brain barrier and result in the stimulation of alpha- and
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beta-adrenergic receptors. Phenylethylamines cause the release |\ |\ |\ |\ |\ |\
of dopamine, serotonin, and norepinephrine and also inhibit
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reuptake.
First-line therapy for agitation is IV benzodiazepines, which
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also treat the hypertension and seizures often seen in these
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patients. Benzodiazepines can also lessen the excessive muscle
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activity that generates heat contributing to hyperthermia. In
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some cases of hyperthermia, neuromuscular paralysis and
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evaporative cooling or ice packs may also be necessary. |\ |\ |\ |\ |\ |\ |\ |\
What are some medications that may cause a false positive for
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amphetamines on a drug test? |\ |\ |\ |\
Answer: |\
Bupropion, |\
,Parkinson agent selegiline, |\ |\ |\
cold preparations containing pseudoephedrine.
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How long qualify delusion disorder?
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presence of one or more delusions with a duration of 1
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month or longer, schizophrenia criteria has never been met,
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functioning is not markedly impaired apart from delusions |\ |\ |\ |\ |\ |\ |\ |\
and their behavioral ramifications, any manic or depressive
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episodes have been brief relative to the duration of the delusion,
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and the disturbance cannot be better attributed to a substance,
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medical condition, or another mental disorder.
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erotomanic
grandiose
persecutory
jealous
mixed
somatic
unspecified
Firstline for delusion disorder? |\ |\ |\
Antipsychotic medications are first-line treatment for |\ |\ |\ |\ |\ |\
delusional disorder. Those with fewer side effects (e.g., |\ |\ |\ |\ |\ |\ |\ |\
aripiprazole, ziprasidone) should be considered with a low |\ |\ |\ |\ |\ |\ |\ |\
initial dose and gradual dosage increases over several days or
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weeks. Psychosocial interventions include cognitive behavioral
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therapy, core family therapy, and supportive therapy.
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Dx for OCPD?
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Diagnostic criteria for obsessive-compulsive personality |\ |\ |\ |\ |\
disorder show a pervasive preoccupation with orderliness,
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perfectionism, and mental or interpersonal control at the |\ |\ |\ |\ |\ |\ |\ |\
, expense of flexibility. It must be present by early adulthood
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and be present in a variety of contexts as indicated by four or
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more of the following criteria: perfectionism that interferes with
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task completion; preoccupation with details, lists, rules,
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organization, order, or schedules so much so that the major point |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
of the activity is lost; overconscientiousness, inflexibility, or
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scrupulousness about matters of ethics, morality, or values; |\ |\ |\ |\ |\ |\ |\ |\
excessive devotion to work and productivity at the exclusion of
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leisure activities and friends; inability to discard old, worn out, or
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worthless objects; miserly spending toward self and others, as|\ |\ |\ |\ |\ |\ |\ |\ |\
money is something to be hoarded toward future catastrophes;
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inability or reluctance to delegate work or tasks to others unless
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they do things exactly the way they are told to; and
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stubbornness and rigidity. |\ |\ |\
Pharmacotherapy is not recommended, as it has not been |\ |\ |\ |\ |\ |\ |\ |\ |\
shown to be an effective treatment. Psychotherapy, either
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group or individual, can be difficult, as many patients do not see
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a problem with their behaviors and ideas.
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diagnostic criteria Schizophrenia dx |\ |\ |\
Positive symptoms of schizophrenia include hallucinations and
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delusions, while negative symptoms present as flattened |\ |\ |\ |\ |\ |\ |\
affect, alogia, apathy, and anhedonia. Patients with schizophrenia
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often display disorganized speech, including tangential
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speech, circumstantial speech, derailment, neologisms, and word
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salad. According to the fifth edition of the Diagnostic and
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Statistical Manual of Mental Disorders, patients must present with
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at least 1 month of delusions, hallucinations, or disorganized
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speech in addition to either negative symptoms or grossly
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disorganized or catatonic behavior. |\ |\ |\
Functional capacity must be impaired by these symptoms for a |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
period of at least 6 months (wherein at least 1 month consists of
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the active-phase symptoms described above).
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