,TESTBANK for Clinical Immunology and Serology A
Laboratory Perspective 5th Edition Linda E. Miller
Notes
1- The file is chapter after chapter.
2- We have shown you few pages sample.
3- The file contains all Appendix and Excel
sheet if it exists.
4- We have all what you need, we make
update at every time. There are many
new editions waiting you.
5- If you think you purchased the wrong file
You can contact us at every time, we can
replace it with true one.
Our email:
,Chapter 1 Introduction to Immunity and the Immune System
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. The scientist known for his use of attenuated vaccines and as the father of immunology is:
a. Edward Jenner. c. Louis Pasteur.
b. Elie Metchnikoff. d. Emil von Behring.
____ 2. The field of immunology can be credited for its contributions to the development of:
a. bacterial identification. c. surgery.
b. vaccines. d. phlebotomy.
____ 3. The ancient practice of inhaling powder from smallpox scabs is an early version of:
a. cross reactivity. c. susceptibility.
b. attenuated vaccination. d. cell identification.
____ 4. Attenuation can take place through ______ a pathogen.
a. Freezing c. Aging
b. Growing d. Flooding
____ 5. Humoral immunity was considered the most important aspect of immunity for a time in history
because of the work of _____________, who received the Nobel Prize in Physiology for his work in
serum therapy.
a. Louis Pasteur c. Almroth Wright
b. Emil von Behring d. Edward Jenner
____ 6. The discovery of _______ helped bring the importance of cellular immunity to light.
a. Antibodies c. Opsonins
b. Phagocytosis d. Bacterial toxin neutralization by serum
____ 7. Phagocytosis is appropriately categorized into which of the following?
a. Adaptive immunity c. Humoral immunity
b. Innate immunity d. Specific immunity
____ 8. A patient with a viral infection that has initiated their cell-mediated immunity might have an
increased number of which leukocytes in their peripheral blood?
a. Lymphocytes c. Monocytes
b. Neutrophils d. Basophils
____ 9. Which of the following cells can phagocytize foreign microbes?
a. T lymphocytes c. Macrophages
b. B lymphocytes d. Natural killer (NK) cells
____ 10. Which of the following cells is a phagocytic cell that has a similar morphology to nerve cells?
a. Neutrophils c. Mast cells
, b. Dendritic cells d. Macrophages
____ 11. Macrophages play a key role in adaptive immunity through which function?
a. Phagocytosis
b. Anti-tumor activity
c. Presenting phagocytosed microbes to T lymphocytes
d. Microbial killing
____ 12. Which is a key antigen-presenting cell found in the digestive tract?
a. Basophil c. Dendritic cell
b. Macrophage d. Mast cell
____ 13. Maturation and differentiation of important immune cells happens within the:
a. blood. c. lymph nodes.
b. bone marrow. d. spleen.
____ 14. A patient with a weakened immune response may need to have which primary lymphoid tissue
examined?
a. Spleen c. Thymus
b. Mucosal associated lymphoid tissue d. Lymph nodes
(MAST)
____ 15. Lymphocytes come in contact with foreign antigens and activate the adaptive immune system in
which lymphoid tissue?
a. Bone marrow c. Thymus
b. Peripheral blood d. Cutaneous-associated lymphoid tissue
(CALT)
____ 16. Which lymphoid tissue can protect us against pathogens we eat?
a. MALT c. Lymph nodes
b. CALT d. Spleen
____ 17. Secondary lymphoid tissues that are located near our joints and serve as a collecting duct for lymph
fluid are:
a. spleen cells. c. MALT.
b. lymph nodes. d. CALT.
____ 18. Foreign microbes that enter through a cut in our hand should expect defense from which lymphoid
tissue?
a. CALT c. MALT
b. Spleen d. Thymus
____ 19. Macrophages line the _______ found within the lymph nodes.
a. Outer cortex c. Paracortex
b. Inner medulla d. Sinuses
,____ 20. B cells activate and generate B-cell memory in the _____ of the lymph nodes.
a. Sinuses c. Paracortex
b. Secondary follicles d. Primary follicles
____ 21. Antigen presentation happens within the ______of the lymph nodes.
a. Primary follicles c. Inner medulla
b. Secondary follicles d. Sinuses
____ 22. We can identify cells by proteins found on their cell surfaces. These are known as:
a. adhesion molecules. c. chemotaxins.
b. antibodies. d. clusters of differentiation.
____ 23. Which CD marker represents those found on B lymphocytes?
a. CD4 c. CD8
b. CD20 d. CD3
____ 24. A patient with antibodies in their serum to a particular virus has activated which immune cells?
a. NK cells c. B lymphocytes
b. Macrophages d. T lymphocytes
____ 25. Humoral immunity is a key function of which cell?
a. NK cells c. Macrophages
b. T lymphocytes d. B lymphocytes
____ 26. Which lymphocyte is part of our innate immunity?
a. CD4 cells c. CD19,20 cells
b. CD8 cells d. NK cells
____ 27. Our first line of defense against virally infected cells and tumor cells are:
a. B lymphocytes. c. neutrophils.
b. T lymphocytes. d. NK cells.
,Chapter 1 Introduction to Immunity and the Immune System
Answer Section
MULTIPLE CHOICE
1. ANS: C PTS: 1 OBJ: 1 MSC: Taxonomy 2
2. ANS: B PTS: 1 OBJ: 1 MSC: Taxonomy 1
3. ANS: B PTS: 1 OBJ: 2 MSC: Taxonomy 2
4. ANS: C PTS: 1 OBJ: 1 MSC: Taxonomy 1
5. ANS: B PTS: 1 OBJ: 3 MSC: Taxonomy 1
6. ANS: B PTS: 1 OBJ: 3 MSC: Taxonomy 2
7. ANS: B PTS: 1 OBJ: 4 MSC: Taxonomy 2
8. ANS: A PTS: 1 OBJ: 4 MSC: Taxonomy 3
9. ANS: C PTS: 1 OBJ: 5 MSC: Taxonomy 1
10. ANS: B PTS: 1 OBJ: 5 MSC: Taxonomy 1
11. ANS: C PTS: 1 OBJ: 6 MSC: Taxonomy 2
12. ANS: D PTS: 1 OBJ: 6 MSC: Taxonomy 1
13. ANS: B PTS: 1 OBJ: 7 MSC: Taxonomy 1
14. ANS: C PTS: 1 OBJ: 7&8 MSC: Taxonomy 3
15. ANS: D PTS: 1 OBJ: 7&8 MSC: Taxonomy 3
16. ANS: A PTS: 1 OBJ: 8 MSC: Taxonomy 3
17. ANS: B PTS: 1 OBJ: 8&9 MSC: Taxonomy 1
18. ANS: A PTS: 1 OBJ: 8 MSC: Taxonomy 3
19. ANS: D PTS: 1 OBJ: 9 MSC: Taxonomy 1
20. ANS: B PTS: 1 OBJ: 9 & 10 MSC: Taxonomy 2
21. ANS: A PTS: 1 OBJ: 9 & 10 MSC: Taxonomy 2
22. ANS: D PTS: 1 OBJ: 11 MSC: Taxonomy 1
23. ANS: B PTS: 1 OBJ: 11 MSC: Taxonomy 1
24. ANS: C PTS: 1 OBJ: 12 MSC: Taxonomy 3
25. ANS: D PTS: 1 OBJ: 12 MSC: Taxonomy 2
26. ANS: D PTS: 1 OBJ: 4, 11, & 13 MSC: Taxonomy 2
27. ANS: D PTS: 1 OBJ: 13 MSC: Taxonomy 2
,Chapter 02 Innate Immunity
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. Which of the following is an internal defense mechanism?
a. Keratin coating epithelial cells c. Surfactant in mucosal secretions
b. Lactic acid in sweat d. Phagocytosis
____ 2. A pathogen killed by psoriasin was defeated by which of the following defense mechanisms?
a. External, adaptive immunity c. Internal, adaptive immunity
b. External, innate immunity d. Internal, innate immunity
____ 3. A pathogen entering the respiratory tract would encounter which external defense mechanism?
a. Phagocytosis c. Hydrochloric acid
b. Movement of cilia d. Lactic acid
____ 4. A pathogen entering the urinary tract would encounter which external defense mechanism?
a. Acidity c. Keratin
b. Surfactants d. Lysozyme
____ 5. Normal flora is best described by which of the following statements?
a. One type of bacteria that is normally present and never causes disease
b. A mix of bacteria that are normally present that never cause disease
c. A mix of bacteria that are normally present and do not typically cause disease
d. One type of bacteria that is normally present and that we constantly are defending
against
____ 6. Inflammatory bowel syndrome may be better understood by looking at which of the following?
a. Interaction between the innate immune system and the gut microbiome
b. Interaction between the innate immune system and Candida albicans
c. Interaction between the adaptive immune system and the gut microbiome
d. Interaction between the adaptive immune system and Candida albicans
____ 7. Which of the following is a pattern-associated molecular pattern (PAMP) found on gram-negative
bacteria?
a. Peptidoglycan c. Flagellin
b. Zymosan d. Lipoproteins
____ 8. Which of the following cells are capable of recognizing PAMPs?
a. B lymphocytes c. Macrophages
b. Basophils d. T lymphocytes
____ 9. Which of the following describes the role of PRRs in adaptive immunity?
a. Promotes release of cytokines and chemokines
b. Activation of phagocytic cells
, c. Activation of inflammation
d. Recruitment of additional phagocytic cells
____ 10. Which best describes the process of a neutrophil recognizing zymosan and phagocytosing a
pathogen?
a. An adaptive immune response to a gram-negative bacterial invasion
b. An innate immune response to a yeast invasion
c. An innate immune response to a gram-negative bacterial invasion
d. An adaptive immune response to a gram-positive bacterial invasion
____ 11. The highest concentration of Toll-like receptors (TLRs) would be found in which of the following
cells?
a. Dendritic cells c. Eosinophils
b. Neutrophils d. Lymphocytes
____ 12. Which of the following TLRs is found on cell surfaces?
a. TLR 3 c. TLR 9
b. TLR 7 d. TLR 2
____ 13. Acute phase reactants act by doing which of the following?
a. Promoting destruction by releasing proteolytic enzymes
b. Promoting adherence to pathogens
c. Limiting phagocytosis
d. Limiting adherence to pathogens
____ 14. Acute phase reactants contribute to innate immunity most through their involvement in which of the
following processes?
a. Destruction of blood clots c. Phagocytosis
b. Surfactant secretion d. Decreasing Ph
____ 15. Which of the following acute phase reactants are capable of opsonization?
a. C-reactive protein c. Alpha 1- Antitrypsin (AAT)
b. Serum amyloid A (SAA) d. Fibrinogen
____ 16. Which of the following acute phase reactants can lyse cells?
a. C-reactive protein c. Haptoglobin
b. Complement d. SAA
____ 17. Which acute phase reactant rises most significantly in bacterial infections?
a. Ceruloplasmin c. Fibrinogen
b. Haptoglobin d. SAA
____ 18. Measurement of C-reactive protein is an established tool in the analysis of which disease?
a. Cardiovascular disease c. Crohn’s disease
b. Irritable bowel syndrome d. Coronary artery disease
____ 19. Which of the following occurs during an inflammatory response?
, a. Constriction of the blood vessels
b. Decreased permeability of fluid through the vessels
c. Diapedesis
d. Migration of macrophages within 30 mins.
____ 20. Which inflammatory response is responsible for the symptom of swelling?
a. Phagocytosis
b. Increased permeability of fluid through vessels
c. Diapedesis
d. Increased blood flow to area
____ 21. Which of the following phagocytic steps should occur after the others?
a. Formation of phagosome c. Outflowing of cytoplasm
b. Release of lysosomal contents d. Fusion of lysosomal granules
____ 22. Which of the following is responsible for digestion of microorganisms through phagocytosis?
a. Phagosome c. Lactic acid
b. Exocytosis d. Hydrolytic enzymes
____ 23. What is the importance of lysosomal granules in phagocytc cells?
a. Proteolytic enzymes are needed for digestion of pathogens
b. Myeloperoxidase is needed or the invagination of the pathogen
c. Proteolytic enzymes are needed to migrate the phagosome to the center of the cell
d. Proteolytic enzymes are needed to fuse granules to the phagosome
____ 24. How do phagocytic cells get pathogens inside their cytoplasm?
a. Adhesion to selectins
b. Chemotaxis
c. Invagination with pseudopods from the cytoplasm
d. Release of proteolytic enzymes from granules
____ 25. Phagocytosis is a critical part of which of the following?
a. Innate, specific, internal defense mechanism
b. Innate, non-specific, internal defense mechanism
c. Innate, non-specific, external defense mechanism
d. Adaptive, specific, internal defense mechanism
____ 26. How does phagocytosis contribute to adaptive immunity?
a. Neutrophils present peptides from pathogens to T cells
b. Neutrophils present peptides from pathogens to B cells
c. Macrophages present peptides from pathogens to B cells
d. Macrophages present peptides from pathogens to T cells
____ 27. Which of the following would best describe the role of NK cells in innate immunity?
a. A school hall monitor c. A school morning greeter
, b. A school custodian d. A school principal
____ 28. NK cells routinely check cells for _____ to determine if they are healthy?
a. Class II major histocompatibility complex
b. Perforins
c. Class I major histocompatibility complex
d. Granzymes
____ 29. Which of the following is a substance released by NK cells and causes channeling into a target cell’s
membrane?
a. Granzymes c. Myeloperoxidase
b. Lactic acid d. Perforins
____ 30. If an NK cell ultimately deems a host cell as unhealthy or infected, the result is:
a. phagocytosis c. inflammatory response
b. cell lysis d. T cell activation
____ 31. Innate lymphoid cells (ILCs) are found primarily where in our bodies?
a. Peripheral blood c. Mucosal sites
b. Bone marrow d. Tissues
____ 32. The primary function of innate lymphoid cells (ILCs)is:
a. release of cytokines c. cell lysis
b. phagocytosis d. inflammation
____ 33. Inhibitory receptors, such as killer cell immunoglobulin-like receptors (KIRs), on the surface of NK
cells bind to which of the following molecules?
a. Toll-like receptors c. Defensins
b. MHC Class I d. Immunoglobulins
____ 34. All of the following are true of dendritic cells except:
a. they ingest both whole microorganisms and injured/dead host cells by
phagocytosis
b. they are capable of presenting pathogen-derived peptide to T cells after
phagocytosis
c. they express TLRs
d. all of the responses are true of dendritic cells
____ 35. Which of the following is true of C-type lectin receptors (CLRs)?
a. CLRs are involved in recognition of intracellular pathogens
b. CLRs are expressed predominantly by NK cells
c. When bound to mannan or β-glucans on fungal cell walls, CLRs result in the
production of cytokines and chemokines
d. CLRs are found on both the plasma membrane and in the cytoplasm of innate
immune cells
Laboratory Perspective 5th Edition Linda E. Miller
Notes
1- The file is chapter after chapter.
2- We have shown you few pages sample.
3- The file contains all Appendix and Excel
sheet if it exists.
4- We have all what you need, we make
update at every time. There are many
new editions waiting you.
5- If you think you purchased the wrong file
You can contact us at every time, we can
replace it with true one.
Our email:
,Chapter 1 Introduction to Immunity and the Immune System
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. The scientist known for his use of attenuated vaccines and as the father of immunology is:
a. Edward Jenner. c. Louis Pasteur.
b. Elie Metchnikoff. d. Emil von Behring.
____ 2. The field of immunology can be credited for its contributions to the development of:
a. bacterial identification. c. surgery.
b. vaccines. d. phlebotomy.
____ 3. The ancient practice of inhaling powder from smallpox scabs is an early version of:
a. cross reactivity. c. susceptibility.
b. attenuated vaccination. d. cell identification.
____ 4. Attenuation can take place through ______ a pathogen.
a. Freezing c. Aging
b. Growing d. Flooding
____ 5. Humoral immunity was considered the most important aspect of immunity for a time in history
because of the work of _____________, who received the Nobel Prize in Physiology for his work in
serum therapy.
a. Louis Pasteur c. Almroth Wright
b. Emil von Behring d. Edward Jenner
____ 6. The discovery of _______ helped bring the importance of cellular immunity to light.
a. Antibodies c. Opsonins
b. Phagocytosis d. Bacterial toxin neutralization by serum
____ 7. Phagocytosis is appropriately categorized into which of the following?
a. Adaptive immunity c. Humoral immunity
b. Innate immunity d. Specific immunity
____ 8. A patient with a viral infection that has initiated their cell-mediated immunity might have an
increased number of which leukocytes in their peripheral blood?
a. Lymphocytes c. Monocytes
b. Neutrophils d. Basophils
____ 9. Which of the following cells can phagocytize foreign microbes?
a. T lymphocytes c. Macrophages
b. B lymphocytes d. Natural killer (NK) cells
____ 10. Which of the following cells is a phagocytic cell that has a similar morphology to nerve cells?
a. Neutrophils c. Mast cells
, b. Dendritic cells d. Macrophages
____ 11. Macrophages play a key role in adaptive immunity through which function?
a. Phagocytosis
b. Anti-tumor activity
c. Presenting phagocytosed microbes to T lymphocytes
d. Microbial killing
____ 12. Which is a key antigen-presenting cell found in the digestive tract?
a. Basophil c. Dendritic cell
b. Macrophage d. Mast cell
____ 13. Maturation and differentiation of important immune cells happens within the:
a. blood. c. lymph nodes.
b. bone marrow. d. spleen.
____ 14. A patient with a weakened immune response may need to have which primary lymphoid tissue
examined?
a. Spleen c. Thymus
b. Mucosal associated lymphoid tissue d. Lymph nodes
(MAST)
____ 15. Lymphocytes come in contact with foreign antigens and activate the adaptive immune system in
which lymphoid tissue?
a. Bone marrow c. Thymus
b. Peripheral blood d. Cutaneous-associated lymphoid tissue
(CALT)
____ 16. Which lymphoid tissue can protect us against pathogens we eat?
a. MALT c. Lymph nodes
b. CALT d. Spleen
____ 17. Secondary lymphoid tissues that are located near our joints and serve as a collecting duct for lymph
fluid are:
a. spleen cells. c. MALT.
b. lymph nodes. d. CALT.
____ 18. Foreign microbes that enter through a cut in our hand should expect defense from which lymphoid
tissue?
a. CALT c. MALT
b. Spleen d. Thymus
____ 19. Macrophages line the _______ found within the lymph nodes.
a. Outer cortex c. Paracortex
b. Inner medulla d. Sinuses
,____ 20. B cells activate and generate B-cell memory in the _____ of the lymph nodes.
a. Sinuses c. Paracortex
b. Secondary follicles d. Primary follicles
____ 21. Antigen presentation happens within the ______of the lymph nodes.
a. Primary follicles c. Inner medulla
b. Secondary follicles d. Sinuses
____ 22. We can identify cells by proteins found on their cell surfaces. These are known as:
a. adhesion molecules. c. chemotaxins.
b. antibodies. d. clusters of differentiation.
____ 23. Which CD marker represents those found on B lymphocytes?
a. CD4 c. CD8
b. CD20 d. CD3
____ 24. A patient with antibodies in their serum to a particular virus has activated which immune cells?
a. NK cells c. B lymphocytes
b. Macrophages d. T lymphocytes
____ 25. Humoral immunity is a key function of which cell?
a. NK cells c. Macrophages
b. T lymphocytes d. B lymphocytes
____ 26. Which lymphocyte is part of our innate immunity?
a. CD4 cells c. CD19,20 cells
b. CD8 cells d. NK cells
____ 27. Our first line of defense against virally infected cells and tumor cells are:
a. B lymphocytes. c. neutrophils.
b. T lymphocytes. d. NK cells.
,Chapter 1 Introduction to Immunity and the Immune System
Answer Section
MULTIPLE CHOICE
1. ANS: C PTS: 1 OBJ: 1 MSC: Taxonomy 2
2. ANS: B PTS: 1 OBJ: 1 MSC: Taxonomy 1
3. ANS: B PTS: 1 OBJ: 2 MSC: Taxonomy 2
4. ANS: C PTS: 1 OBJ: 1 MSC: Taxonomy 1
5. ANS: B PTS: 1 OBJ: 3 MSC: Taxonomy 1
6. ANS: B PTS: 1 OBJ: 3 MSC: Taxonomy 2
7. ANS: B PTS: 1 OBJ: 4 MSC: Taxonomy 2
8. ANS: A PTS: 1 OBJ: 4 MSC: Taxonomy 3
9. ANS: C PTS: 1 OBJ: 5 MSC: Taxonomy 1
10. ANS: B PTS: 1 OBJ: 5 MSC: Taxonomy 1
11. ANS: C PTS: 1 OBJ: 6 MSC: Taxonomy 2
12. ANS: D PTS: 1 OBJ: 6 MSC: Taxonomy 1
13. ANS: B PTS: 1 OBJ: 7 MSC: Taxonomy 1
14. ANS: C PTS: 1 OBJ: 7&8 MSC: Taxonomy 3
15. ANS: D PTS: 1 OBJ: 7&8 MSC: Taxonomy 3
16. ANS: A PTS: 1 OBJ: 8 MSC: Taxonomy 3
17. ANS: B PTS: 1 OBJ: 8&9 MSC: Taxonomy 1
18. ANS: A PTS: 1 OBJ: 8 MSC: Taxonomy 3
19. ANS: D PTS: 1 OBJ: 9 MSC: Taxonomy 1
20. ANS: B PTS: 1 OBJ: 9 & 10 MSC: Taxonomy 2
21. ANS: A PTS: 1 OBJ: 9 & 10 MSC: Taxonomy 2
22. ANS: D PTS: 1 OBJ: 11 MSC: Taxonomy 1
23. ANS: B PTS: 1 OBJ: 11 MSC: Taxonomy 1
24. ANS: C PTS: 1 OBJ: 12 MSC: Taxonomy 3
25. ANS: D PTS: 1 OBJ: 12 MSC: Taxonomy 2
26. ANS: D PTS: 1 OBJ: 4, 11, & 13 MSC: Taxonomy 2
27. ANS: D PTS: 1 OBJ: 13 MSC: Taxonomy 2
,Chapter 02 Innate Immunity
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. Which of the following is an internal defense mechanism?
a. Keratin coating epithelial cells c. Surfactant in mucosal secretions
b. Lactic acid in sweat d. Phagocytosis
____ 2. A pathogen killed by psoriasin was defeated by which of the following defense mechanisms?
a. External, adaptive immunity c. Internal, adaptive immunity
b. External, innate immunity d. Internal, innate immunity
____ 3. A pathogen entering the respiratory tract would encounter which external defense mechanism?
a. Phagocytosis c. Hydrochloric acid
b. Movement of cilia d. Lactic acid
____ 4. A pathogen entering the urinary tract would encounter which external defense mechanism?
a. Acidity c. Keratin
b. Surfactants d. Lysozyme
____ 5. Normal flora is best described by which of the following statements?
a. One type of bacteria that is normally present and never causes disease
b. A mix of bacteria that are normally present that never cause disease
c. A mix of bacteria that are normally present and do not typically cause disease
d. One type of bacteria that is normally present and that we constantly are defending
against
____ 6. Inflammatory bowel syndrome may be better understood by looking at which of the following?
a. Interaction between the innate immune system and the gut microbiome
b. Interaction between the innate immune system and Candida albicans
c. Interaction between the adaptive immune system and the gut microbiome
d. Interaction between the adaptive immune system and Candida albicans
____ 7. Which of the following is a pattern-associated molecular pattern (PAMP) found on gram-negative
bacteria?
a. Peptidoglycan c. Flagellin
b. Zymosan d. Lipoproteins
____ 8. Which of the following cells are capable of recognizing PAMPs?
a. B lymphocytes c. Macrophages
b. Basophils d. T lymphocytes
____ 9. Which of the following describes the role of PRRs in adaptive immunity?
a. Promotes release of cytokines and chemokines
b. Activation of phagocytic cells
, c. Activation of inflammation
d. Recruitment of additional phagocytic cells
____ 10. Which best describes the process of a neutrophil recognizing zymosan and phagocytosing a
pathogen?
a. An adaptive immune response to a gram-negative bacterial invasion
b. An innate immune response to a yeast invasion
c. An innate immune response to a gram-negative bacterial invasion
d. An adaptive immune response to a gram-positive bacterial invasion
____ 11. The highest concentration of Toll-like receptors (TLRs) would be found in which of the following
cells?
a. Dendritic cells c. Eosinophils
b. Neutrophils d. Lymphocytes
____ 12. Which of the following TLRs is found on cell surfaces?
a. TLR 3 c. TLR 9
b. TLR 7 d. TLR 2
____ 13. Acute phase reactants act by doing which of the following?
a. Promoting destruction by releasing proteolytic enzymes
b. Promoting adherence to pathogens
c. Limiting phagocytosis
d. Limiting adherence to pathogens
____ 14. Acute phase reactants contribute to innate immunity most through their involvement in which of the
following processes?
a. Destruction of blood clots c. Phagocytosis
b. Surfactant secretion d. Decreasing Ph
____ 15. Which of the following acute phase reactants are capable of opsonization?
a. C-reactive protein c. Alpha 1- Antitrypsin (AAT)
b. Serum amyloid A (SAA) d. Fibrinogen
____ 16. Which of the following acute phase reactants can lyse cells?
a. C-reactive protein c. Haptoglobin
b. Complement d. SAA
____ 17. Which acute phase reactant rises most significantly in bacterial infections?
a. Ceruloplasmin c. Fibrinogen
b. Haptoglobin d. SAA
____ 18. Measurement of C-reactive protein is an established tool in the analysis of which disease?
a. Cardiovascular disease c. Crohn’s disease
b. Irritable bowel syndrome d. Coronary artery disease
____ 19. Which of the following occurs during an inflammatory response?
, a. Constriction of the blood vessels
b. Decreased permeability of fluid through the vessels
c. Diapedesis
d. Migration of macrophages within 30 mins.
____ 20. Which inflammatory response is responsible for the symptom of swelling?
a. Phagocytosis
b. Increased permeability of fluid through vessels
c. Diapedesis
d. Increased blood flow to area
____ 21. Which of the following phagocytic steps should occur after the others?
a. Formation of phagosome c. Outflowing of cytoplasm
b. Release of lysosomal contents d. Fusion of lysosomal granules
____ 22. Which of the following is responsible for digestion of microorganisms through phagocytosis?
a. Phagosome c. Lactic acid
b. Exocytosis d. Hydrolytic enzymes
____ 23. What is the importance of lysosomal granules in phagocytc cells?
a. Proteolytic enzymes are needed for digestion of pathogens
b. Myeloperoxidase is needed or the invagination of the pathogen
c. Proteolytic enzymes are needed to migrate the phagosome to the center of the cell
d. Proteolytic enzymes are needed to fuse granules to the phagosome
____ 24. How do phagocytic cells get pathogens inside their cytoplasm?
a. Adhesion to selectins
b. Chemotaxis
c. Invagination with pseudopods from the cytoplasm
d. Release of proteolytic enzymes from granules
____ 25. Phagocytosis is a critical part of which of the following?
a. Innate, specific, internal defense mechanism
b. Innate, non-specific, internal defense mechanism
c. Innate, non-specific, external defense mechanism
d. Adaptive, specific, internal defense mechanism
____ 26. How does phagocytosis contribute to adaptive immunity?
a. Neutrophils present peptides from pathogens to T cells
b. Neutrophils present peptides from pathogens to B cells
c. Macrophages present peptides from pathogens to B cells
d. Macrophages present peptides from pathogens to T cells
____ 27. Which of the following would best describe the role of NK cells in innate immunity?
a. A school hall monitor c. A school morning greeter
, b. A school custodian d. A school principal
____ 28. NK cells routinely check cells for _____ to determine if they are healthy?
a. Class II major histocompatibility complex
b. Perforins
c. Class I major histocompatibility complex
d. Granzymes
____ 29. Which of the following is a substance released by NK cells and causes channeling into a target cell’s
membrane?
a. Granzymes c. Myeloperoxidase
b. Lactic acid d. Perforins
____ 30. If an NK cell ultimately deems a host cell as unhealthy or infected, the result is:
a. phagocytosis c. inflammatory response
b. cell lysis d. T cell activation
____ 31. Innate lymphoid cells (ILCs) are found primarily where in our bodies?
a. Peripheral blood c. Mucosal sites
b. Bone marrow d. Tissues
____ 32. The primary function of innate lymphoid cells (ILCs)is:
a. release of cytokines c. cell lysis
b. phagocytosis d. inflammation
____ 33. Inhibitory receptors, such as killer cell immunoglobulin-like receptors (KIRs), on the surface of NK
cells bind to which of the following molecules?
a. Toll-like receptors c. Defensins
b. MHC Class I d. Immunoglobulins
____ 34. All of the following are true of dendritic cells except:
a. they ingest both whole microorganisms and injured/dead host cells by
phagocytosis
b. they are capable of presenting pathogen-derived peptide to T cells after
phagocytosis
c. they express TLRs
d. all of the responses are true of dendritic cells
____ 35. Which of the following is true of C-type lectin receptors (CLRs)?
a. CLRs are involved in recognition of intracellular pathogens
b. CLRs are expressed predominantly by NK cells
c. When bound to mannan or β-glucans on fungal cell walls, CLRs result in the
production of cytokines and chemokines
d. CLRs are found on both the plasma membrane and in the cytoplasm of innate
immune cells
