ff ff ff ff ff ff ff ff
ff
Table of Contents:
ff ff
Chapter 1: Cell Adaptation, Injury and Death
ff ff ff ff ff ff
Chapter 2: Inflammation
ff ff
Chapter 3: Repair, Regeneration and Fibrosis
ff ff ff ff ff
Chapter 4: Immunopathology
ff ff
Chapter 5: Neoplasia
ff ff
Chapter 6: Developmental and Genetic Diseases
ff ff ff ff ff
Chapter 7: Hemodynamic Disorders
ff ff ff
Chapter 8: Environmental and Nutritional Pathology
ff ff ff ff ff
Chapter 9: Infectious and Parasitic Diseases
ff ff ff ff ff
Section II: Pathogenesis of Systemic Conditions Expandable section
ff ff ff ff ff ff ff
Chapter 10: Aging
ff ff
Chapter 11: Systemic Autoimmune Diseases
ff ff ff ff
Chapter 12: Sepsis
ff ff
Chapter 13: Obesity and Diabetes Mellitus
ff ff ff ff ff
Chapter 14: The Pathology of Pregnancy
ff ff ff ff ff
Chapter 15: The Amyloidoses
ff ff ff
Section III: Diseases of Individual Organ SystemsExpandable section
ff ff ff ff ff ff ff
Chapter 16: Blood Vessels
ff ff ff
Chapter 17: The Heart
ff ff ff
Chapter 18: The Respiratory System
ff ff ff ff
Chapter 19: The Gastrointestinal Tract
ff ff ff ff
Chapter 20: The Liver and Biliary System
ff ff ff ff ff ff
Chapter 21: The Pancreas
ff ff ff
Chapter 22: The Kidney
ff ff ff
Chapter 23: The Lower Urinary Tract and Male Reproductive System
ff ff ff ff ff ff ff ff ff
Chapter 24: The Female Reproductive System and Peritoneum
ff ff ff ff ff ff ff
Chapter 25: The Breast
ff ff ff
Chapter 26: Hematopathology
ff ff
Chapter 27: The Endocrine System
ff ff ff ff
Chapter 28: The Skin
ff ff ff
Chapter 29: The Head and Neck
ff ff ff ff ff
Chapter 30: Bones, Joints and Soft Tissue
ff ff ff ff ff ff
Chapter 31: Skeletal Muscle and Peripheral Nervous System
ff ff ff ff ff ff ff
Chapter 32: The Central Nervous System
ff ff ff ff ff
Chapter 33: The Eye
ff ff ff
Chapter 34: Forensic Pathology
ff ff ff
,Rubin's Pathology: Clinicopathologic Foundations of Medicine
ff ff ff ff ff
Chapter 1: Cell Adaptation, Injury and Death
ff ff ff ff ff ff ff
Ischemia and other toxic injuries increase the accumulation of intracellular calcium as a result
ff ff ff ff ff ff ff ff ff ff ff ff ff
1. of:
ff
A) release of stored calcium from the mitochondria.
ff ff ff ff ff ff
B) improved intracellular volume regulation. ff ff ff
C) decreased influx across the cell membrane. ff ff ff ff ff
D) attraction of calcium to fatty infiltrates. ff ff ff ff ff
The patient is found to have liver disease, resulting in the removal of a lobe of his liver.
ff ff ff ff ff ff ff ff ff ff ff ff ff ff ff ff ff
2. Adaptation to the reduced size of the liver leads to _
ff ff of the remaining liver cells.
ff ff ff ff ff ff ff ff ff ff ff ff ff
A) metaplasia
B) organ atrophy ff
C) compensatory hyperplasia ff
D) physiologic hypertrophy ff
A person eating peanuts starts choking and collapses. His airway obstruction is
ff ff ff ff ff ff ff ff ff ff ff
partially cleared, but he remains hypoxic until he reaches the hospital. The prolonged
ff ff ff ff ff ff ff ff ff ff ff ff ff
3. cell hypoxia caused a cerebral infarction and resulting _ in the brain.
ff ff ff ff ff ff ff ff ff ff ff
A) caspase activation ff
B) coagulation necrosis ff
C) rapid phagocytosis ff
D) protein p53 deficiency ff ff
Bacteria and viruses cause cell damage by
ff ff ff ff ff ff , which is unique from the intracellular
ff ff ff ff ff ff
4. damage caused by other injurious agents.
ff ff ff ff ff ff
A) disrupting the sodium/potassium ATPase pump ff ff ff ff
B) interrupting oxidative metabolism processes ff ff ff
C) replicating and producing continued injury ff ff ff ff
D) decreasing protein synthesis and function ff ff ff ff
The patient has a prolonged interruption in arterial blood flow to his left kidney, causing
ff ff ff ff ff ff ff ff ff ff ff ff ff ff
5. hypoxic cell injury and the release of free radicals. Free radicals damage cells by:
ff ff ff ff ff ff ff ff ff ff ff ff ff ff
A) destroying phospholipids in the cell membrane. ff ff ff ff ff
B) altering the immune response of the cell.
ff ff ff ff ff ff
C) disrupting calcium storage in the cell. ff ff ff ff ff
D) inactivation of enzymes and mitochondria. ff ff ff ff
, 6. Injured cells have impaired flow of substances through the cell membrane as a result of:
ff ff ff ff ff ff ff ff ff ff ff ff ff ff
A) increased fat load. ff ff
B) altered permeability. ff
C) altered glucose utilization. ff ff
D) increased surface receptors. ff ff
7. Reversible adaptive intracellular responses are initiated by:
ff ff ff ff ff ff
A) stimulus overload. ff
B) genetic mutations. ff
C) chemical messengers. ff
D) mitochondrial DNA. ff
8. Injured cells become very swollen as a result of:
ff ff ff ff ff ff ff ff
A) increased cell protein synthesis. ff ff ff
B) altered cell volume regulation. ff ff ff
C) passive entry of potassium into the cell. ff ff ff ff ff ff
D) bleb formation in the plasma membrane.
ff ff ff ff ff
A diabetic patient has impaired sensation, circulation, and oxygenation of his feet. He steps
ff ff ff ff ff ff ff ff ff ff ff ff ff
on a piece of glass, the wound does not heal, and the area tissue becomes necrotic. The
ff ff ff ff ff ff ff ff ff ff ff ff ff ff ff ff ff
9. necrotic cell death is characterized by:
ff ff ff ff ff ff
A) rapid apoptosis. ff
B) cellular rupture. ff
C) shrinkage and collapse. ff ff
D) chronic inflammation. ff
A 99-year-old woman has experienced the decline of cell function associated with age. A
ff ff ff ff ff ff ff ff ff ff ff ff ff
10. group of theories of cellular aging focus on programmed:
ff ff ff ff ff ff ff ff ff
A) changes with genetic influences. ff ff ff
B) elimination of cell receptor sites. ff ff ff ff
C) insufficient telomerase enzyme. ff ff
D) DNA mutation or faulty repair.
ff ff ff ff
An 89-year-old female patient has experienced significant decreases in her mobility and
ff ff ff ff ff ff ff ff ff ff ff
stamina during a 3-week hospital stay for the treatment of a femoral head fracture. Which of
ff ff ff ff ff ff ff ff ff ff ff ff ff ff ff ff
the following phenomena most likely accounts for the patients decrease in muscle function
ff ff ff ff ff ff ff ff ff ff ff ff ff
11. that underlies her reduced mobility?
ff ff ff ff ff
A) Impaired muscle cell metabolism resulting from metaplasiaff ff ff ff ff ff
B) Dysplasia as a consequence of inflammation during bone remodeling
ff ff ff ff ff ff ff ff
C) Disuse atrophy of muscle cells during a prolonged period of immobility
ff ff ff ff ff ff ff ff ff ff