CHE 4342 EXAM 4 QUESTIONS AND 100%
CORRECT ANSWERS!!
What reaction is catalyzed by Transaminase or Aminotransferase?
Removal of alpha-amino group Occurs in liver cytosol
(REQUIRES PLP)
(Ping-Pong reaction)
What reaction releases NH4 and where is it released?
Glutamate moves into mito matrix and Glutamate DH releases NH4
How is Glutamate DH regulated?
Releases NH4 in liver mito matrix; Operates at intersection of N and C metabolism
Activated by ADP and GDP
Inhibited by ATP and GTP
How is ammonium transported to the liver?
Glutamine or Glucose-Alanine Cycle
1. Glutaminase releases NH4 in liver mito matrix
2. Alanine transaminase (ALT) converts glutamate to alanine, then alanine is used to create
Glutamate
What are the different types of ammonium ion?
Ammonia (Fish)
Urea (Mammals)
Uric Acid (Reptiles, Birds)
How is Carbamoyl Phosphate formed?
CPS1 in mito matrix uses NH4 and CO2 + 2 ATP to create CP
MAIN CONTROL POINT
ACTIVATED BY ACETYL-GLUTAMATE
, TUC?
Ornithine, Citrulline, Argininosuccinate, Arginine
Ornithine transcarbamolyase,
Argininosuccinate synthase, Argininosuccinase, Arginase
What enzymes in the TUC are found in the mito?
CPS1, ornithine transcarbomylase
Ornithine and Citrulline can cross
What links the TUC with the Krebs?
Fumarate
What AAs are both ketogenic and glucogenic? Which ones are ketogenic?
IPTTT
Lucy-Lys
What AAs are catabolized into Pyruvate?
Ala, Cys, Gly, Ser, Thr, Trp
Alanine Transferase
Ser Dehydratase (PLP)
Gly Cleavage System
What disease is caused by a folate deficiency?
Neural tube defects
THF Cycle
DHFR makes THF from Folate
GCS or Ser used to make N5N10 THF
MTHFR makes N5 methyl-THF
What AAs are catabolized into Succinyl-CoA?
CORRECT ANSWERS!!
What reaction is catalyzed by Transaminase or Aminotransferase?
Removal of alpha-amino group Occurs in liver cytosol
(REQUIRES PLP)
(Ping-Pong reaction)
What reaction releases NH4 and where is it released?
Glutamate moves into mito matrix and Glutamate DH releases NH4
How is Glutamate DH regulated?
Releases NH4 in liver mito matrix; Operates at intersection of N and C metabolism
Activated by ADP and GDP
Inhibited by ATP and GTP
How is ammonium transported to the liver?
Glutamine or Glucose-Alanine Cycle
1. Glutaminase releases NH4 in liver mito matrix
2. Alanine transaminase (ALT) converts glutamate to alanine, then alanine is used to create
Glutamate
What are the different types of ammonium ion?
Ammonia (Fish)
Urea (Mammals)
Uric Acid (Reptiles, Birds)
How is Carbamoyl Phosphate formed?
CPS1 in mito matrix uses NH4 and CO2 + 2 ATP to create CP
MAIN CONTROL POINT
ACTIVATED BY ACETYL-GLUTAMATE
, TUC?
Ornithine, Citrulline, Argininosuccinate, Arginine
Ornithine transcarbamolyase,
Argininosuccinate synthase, Argininosuccinase, Arginase
What enzymes in the TUC are found in the mito?
CPS1, ornithine transcarbomylase
Ornithine and Citrulline can cross
What links the TUC with the Krebs?
Fumarate
What AAs are both ketogenic and glucogenic? Which ones are ketogenic?
IPTTT
Lucy-Lys
What AAs are catabolized into Pyruvate?
Ala, Cys, Gly, Ser, Thr, Trp
Alanine Transferase
Ser Dehydratase (PLP)
Gly Cleavage System
What disease is caused by a folate deficiency?
Neural tube defects
THF Cycle
DHFR makes THF from Folate
GCS or Ser used to make N5N10 THF
MTHFR makes N5 methyl-THF
What AAs are catabolized into Succinyl-CoA?
