Test Bank For Cellular and Molecular Immunology, 10th Edition by Abul K. Abbas| All Chapters 1-21| Latest Edition 2025

TEST BANK X;




Cellular and Molecular Immunology
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Abul Abbas, Andrew Lichtman, and Shiv Pillai
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10th Edition
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,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
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Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
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Chapter 04 Innate Immunity
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Chapter 05 Antibodies and Antigens
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Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Molecules
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Chapter 07 Immune Receptors and Signal Transduction
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Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
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Chapter 09 Activation of T Lymphocytes
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Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
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Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
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Chapter 12 B Cell Activation and Antibody Production
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Chapter 13 Effector Mechanisms of Humoral Immunity
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Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
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Chapter 15 Immunologic Tolerance and Autoimmunity
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Chapter 16 Immunity to Microbes
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Chapter 17 Transplantation Immunology
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Chapter 18 Tumor Immunology
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Chapter 19 Hypersensitivity Disorders
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Chapter 20 Allergy
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Chapter 21 Primary and Acquired Immunodeficiencies
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,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
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MULTIPLE CHOICE X;




1. The principal function of the immune system is:
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a. Defense against cancer X; X;


b. Repair of injured tissues X; X; X;


c. Defense against microbial infections X; X; X;


d. Prevention of inflammatory diseases X; X; X;


e. Protection against environmental toxins X; X; X;




ANS: C X ;


The immune system has evolved in the setting of selective pressures imposed by microbi
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al infections. Although immune responses to cancer may occur, the concept that ―immun
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osurveillance‖ against cancer is a principal function of the immune system is controversi
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al. Repair of injured tissues may be a secondary consequence of the immune responses a
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nd inflammation. Although the immune system has regulatory features that are needed to
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prevent excessive inflammation, prevention of inflammatory diseases is not a primary fu
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nction. The immune system can protect against microbial toxins, but it generally does not
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offer protection against toxins of nonbiologic origin.
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2. Which of the following infectious diseases was prevented by the first successf
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ul vaccination?
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a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C X ;


In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
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gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980
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, smallpox was reported to be eradicated worldwide by a vaccination program. Effective
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vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th c
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entury and are widely used. There is no effective vaccine against Mycobacterium tubercu
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losis.

3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens
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b. Self-nonself discrimination X;


c. Recognition of microbial structures by both cell-associated and soluble receptors
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d. Protection against viral infections X; X; X;


e. Responses that have the same kinetics and magnitude on repeated exposure to t
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he same microbe X; X;




ANS: X ; A

, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
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cytes, which are the central cellular components of the adaptive immune system. Both th
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e innate and the adaptive immune systems use cell-
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associated and soluble receptors to recognize microbes, display some degree of self-
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nonself discrimination, and protect against viruses. On repeated exposure to the same mi
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crobe, the adaptive immune response becomes more rapid and of greater magnitude; this
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is the manifestation of memory.
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4. Antibodies and T lymphocytes are the respective mediators of which two types
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of immunity?
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a. Innate and adaptive X; X;


b. Passive and active X; X;


c. Specific and nonspecific X; X;


d. Humoral and cell-mediated X; X;


e. Adult and neonatal X; X;




ANS: D X ;


Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
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s produce antibodies, which are the recognition and effector molecules of humoral immun
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e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
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ellular pathogens in cell- X; X; X;


mediated immunity. Passive and active immunity both can be mediated by either B or T ly
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mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymp
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hocytes participate in adult adaptive immunity but are still developing in the neonatal peri
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od.

5. The two major functional classes of effector T lymphocytes are:
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a. Helper T lymphocytes and cytotoxic T lymphocytes X; X; X; X; X; X;


b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes X; X; X; X;


c. Memory T cells and effector T cells X; X; X; X; X; X;


d. Helper cells and antigen-presenting cells X; X; X; X;


e. Cytotoxic T lymphocytes and target cells X; X; X; X; X;




ANS: A X ;


T cells can be classified into effector subsets that perform different effector functions. Mo
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st effector T cells are either helper T lymphocytes, which enhance the responses of other
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immune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocyt
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es, which directly kill infected cells. Natural killer cells are not T lymphocytes.
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Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. X; X; X; X; X; X; X; X; X; X; X; X; X; X;




6. Which of the following cell types is required for all adaptive humoral immune responses?
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a. Natural killer cells X; X;


b. Dendritic cells X;


c. Cytolytic T lymphocytes X; X;


d. B lymphocytes X;


e. Helper T lymphocytes X; X;




ANS: D X ;


Humoral immune responses are antibody- X; X; X; X;


mediated immune responses, and all antibodies are made by B lymphocytes and no oth
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er cell type.
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