NR546 Week 3 Antipsychotic Medications
UPDATED ACTUAL Exam Questions and
CORRECT Answers
Pines - CORRECT ANSWER - bind more potently to the 5HT 2A receptor than the D2.
Sedation is common and relates to a high affinity for histamine. These medications have the least
risk of EPS but a high risk for weight gain and metabolic abnormalities.
olanzapine (Zyprexa) - CORRECT ANSWER - treatment of schizophrenia age 13 and
older
Special Comments: Best tolerated antipsychotic
Risk:
High metabolic risk
Highest risk for weight gain, blood dyscrasias, QT prolongation, cardiovascular disease,
cerebrovascular effects, hyperglycemia, and hyperprolactinemia
quetiapine (Seroquel) - CORRECT ANSWER - use for schizophrenia ages 13 and older
Risk:
Moderate metabolic risk
Low EPS risk
Risk of orthostatic hypotension, blood dyscrasias (neutropenia, leukopenia, and agranulocytosis),
QT prolongation, weight gain, and renal and hepatic impairment
asenapine (Saphris) - CORRECT ANSWER - approved for schizophrenia ages 10 and
older
Special Comments: Available in sublingual and transdermal patch
Risk:
, Low metabolic risk
clozapine (Clozaril) - CORRECT ANSWER - Approved for treatment-resistant
schizophrenia and chronic suicidal behavior in schizophrenia or schizoaffective disorder
Not indicated in acute presentation of schizophrenia
Special Comments: The Absolute Neutrophil Count (ANC) must be >1500/mm3 when used and
requires initial and weekly monitoring of WBC, granulocyte, and neutrophil counts.
Risk:
High metabolic risk
Highest risk for weight gain.
Low EPS risk.
Black box warning: may cause severe neutropenia
Contraindicated in liver disease and hepatic failure
Not a first-choice mediation for treating schizophrenia
Psychosis - CORRECT ANSWER - makes people feel out of control and out of touch with
reality
Antipsychotic meds can help relieve sx
positive symptoms of schizophrenia - CORRECT ANSWER - hallucinations
delusions
Thought disorder
Hostility
Excitability
UPDATED ACTUAL Exam Questions and
CORRECT Answers
Pines - CORRECT ANSWER - bind more potently to the 5HT 2A receptor than the D2.
Sedation is common and relates to a high affinity for histamine. These medications have the least
risk of EPS but a high risk for weight gain and metabolic abnormalities.
olanzapine (Zyprexa) - CORRECT ANSWER - treatment of schizophrenia age 13 and
older
Special Comments: Best tolerated antipsychotic
Risk:
High metabolic risk
Highest risk for weight gain, blood dyscrasias, QT prolongation, cardiovascular disease,
cerebrovascular effects, hyperglycemia, and hyperprolactinemia
quetiapine (Seroquel) - CORRECT ANSWER - use for schizophrenia ages 13 and older
Risk:
Moderate metabolic risk
Low EPS risk
Risk of orthostatic hypotension, blood dyscrasias (neutropenia, leukopenia, and agranulocytosis),
QT prolongation, weight gain, and renal and hepatic impairment
asenapine (Saphris) - CORRECT ANSWER - approved for schizophrenia ages 10 and
older
Special Comments: Available in sublingual and transdermal patch
Risk:
, Low metabolic risk
clozapine (Clozaril) - CORRECT ANSWER - Approved for treatment-resistant
schizophrenia and chronic suicidal behavior in schizophrenia or schizoaffective disorder
Not indicated in acute presentation of schizophrenia
Special Comments: The Absolute Neutrophil Count (ANC) must be >1500/mm3 when used and
requires initial and weekly monitoring of WBC, granulocyte, and neutrophil counts.
Risk:
High metabolic risk
Highest risk for weight gain.
Low EPS risk.
Black box warning: may cause severe neutropenia
Contraindicated in liver disease and hepatic failure
Not a first-choice mediation for treating schizophrenia
Psychosis - CORRECT ANSWER - makes people feel out of control and out of touch with
reality
Antipsychotic meds can help relieve sx
positive symptoms of schizophrenia - CORRECT ANSWER - hallucinations
delusions
Thought disorder
Hostility
Excitability
