to accompany
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Psychopharmacology, Third Edition vv vv
Meyer • Quenzer vv vv
Chapter 1: Principles of Pharmacology vv vv vv vv
Multiple Choice vv
1. refer(s) to specific molecular changes that occur when a drug binds to a vv vv vv vv vv vv vv vv vv vv vv vv
particular target site or receptor, while
vv vv are the resulting widespread alterations
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in function.
vv vv
a. Drug action; therapeutic effects
vv vv vv
b. Side effects; drug effects
vv vv vv
c. Therapeutic effects; side effects vv vv vv
d. Drug action; drug effects vv vv vv
Answer: d vv
Textbook Reference: Pharmacology: The Science of Drug Action
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2. After drug administration has occurred, the amount of drug in the blood that is free
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to bind at specific target sites is referred to as
vv vv vv vv vv vv vv vv vv vv
a. the therapeutic dose.
vv vv
b. first-pass effects. vv
c. bioavailability.
d. ED50.
Answer: c vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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3. The specific molecular changes that occur when a drug binds to a particular target
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site or receptor are referred to as
vv vv vv vv vv vv vv
a. drug effects. vv
b. drug action. vv
c. side effects. vv
d. placebo effects. vv
Answer: b vv
Textbook Reference: Pharmacology: The Science of Drug Action
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4. Which of the following is not a possible explanation for placebo effects?
vv vv vv vv vv vv vv vv vv vv vv
a. Pavlovian conditioning vv
b. Genetic variation vv
c. Drug competition vv
d. Expectation of outcome vv vv
Answer: c vv
Textbook Reference: Pharmacology: The Science of Drug Action
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,5. The administration of oxytocin has been proposed as a treatment for autism. vv vv vv vv vv vv vv vv vv vv
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
vv vv vv vv vv vv
6. Which factor does not affect the pharmacokinetics of a drug?
vv vv vv vv vv vv vv vv vv
a. Route of administration
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b. Lipid solubility
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c. Depot binding vv
d. Drug action vv
Answer: d vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
vv vv vv vv vv vv
7. First-pass metabolism occurs when drugs are taken
vv vv vv vv vv vv
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
vv vv vv vv vv vv
8. The area postrema is one area in the brain where the
vv vv is not complete. vv vv vv vv vv vv vv vv vv vv
a. cerebrospinal fluid vv
b. blood–brain barrier vv
c. choroid plexus vv
d. phospholipid membrane vv
Answer: b vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
vv vv vv vv vv vv
9. First-pass metabolism occurs with orally administered drugs because
vv vv vv vv vv vv vv
a. their absorption is slowed by food.
vv vv vv vv vv
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way
vv vv vv vv vv vv vv vv vv vv vv vv vv vv
to general circulation.
vv vv vv
c. drugs must first survive the acidic environment of the stomach.
vv vv vv vv vv vv vv vv vv
d. salivary enzymes in the mouth begin the process of metabolism.
vv vv vv vv vv vv vv vv vv
Answer: b vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
vv vv vv vv vv vv
10. Toxic substances in the blood trigger a vomiting response by activating the
vv vv vv vv vv vv vv vv vv vv vv
a. blood–brain barrier. vv
b. choroid plexus. vv
c. area postrema.
vv
d. median eminence. vv
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vv vv vv
, Answer: c vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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11. Drugs administered _ have the most rapid onset of action.
vv vv vv vv vv vv vv vv
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
vv vv vv vv vv vv
12. Ionization of a drug depends on the of the solution and the
vv vv vv vv vv vv vv vv vv vv of the
vv
drug.
vv
a. pH; pKa
vv
b. pKa; pH vv
c. concentration; lipid solubility vv vv
d. pH; concentration
vv
Answer: a vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
vv vv vv vv vv vv
13. The absorption of a drug depends on all of the following except
vv vv vv vv vv vv vv vv vv vv vv
a. lipid solubility.
vv
b. ionization.
c. body temperature.
vv
d. the concentration of the drug.
vv vv vv vv
Answer: c vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
vv vv vv vv vv vv
14. Drugs that are should be avoided by women of childbearing age.
vv vv vv vv vv vv vv vv vv
a. teratogenic
b. able to cross the placental barrier
vv vv vv vv vv
c. psychoactive
d. highly lipid-soluble vv
Answer: a vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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15. Agents that induce developmental abnormalities in a fetus are known as
vv vv vv vv vv vv vv vv vv vv
a. psychoactive drugs. vv
b. illicit drugs. vv
c. teratogens.
d. placental drugs. vv
Answer: c vv
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
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16. Depot binding is said to occur when drugs
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a. bind to their target sites.
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