PC707 Module 1 / Comprehensive Study Guide
Complete Questions and Correct Detailed Answers
What is prescriptive authority? - (ANSWER)Legal right to prescribe drugs
Is the Physicians Desk Reference a reliable source to use when prescribing drugs?
- (ANSWER)No--it is not evidence-based and it is not updated
What is the sunshine act? - (ANSWER)-part of the affordable care act
-limits providers on accepting gifts from pharmaceutical companies
-reduces bias
What is pharmacology? - (ANSWER)-study of the drugs and their actions and
effects on living things
-legal drugs, illegal drugs, prescription drugs, OTC drugs
How does the FDA define drugs that they approve? - (ANSWER)-chemicals that
have been proved for safety and efficacy
What must providers consider when prescribing? - (ANSWER)-the dose
-the route of administration
-indications
-side effects of consequence
-adverse effects
,-contraindications
-significant drug-drug interactions
-appropriate monitoring
-treatment of side effects if necessary
What is pharmacokinetics? - (ANSWER)-how drugs move in the body and what
the body does with it
How does pharmacokinetics influence prescribing? - (ANSWER)-the route
-the dosage needed
-dosing intervals
What are the 4 aspects of pharmacokinetics? - (ANSWER)-absorption
-distribution
-metabolism
-excretion
What affects bioavailability the most? - (ANSWER)PO administration
What is a pro-drug? - (ANSWER)-a drug that needs to be metabolized to become
"activated"
, What is the major organ of metabolism? - (ANSWER)-Liver
-Uses enzymes called "CYPs"
-these enzymes can induce or inhibit metabolism
What is protein-binding? - (ANSWER)-drugs that have a high affinity for proteins
will bind with them and therefore become unable to bind to receptor sites
-in order to activate receptors they must be free circulating molecules
What is the half-life of a drug? - (ANSWER)-how long it takes for a drug at its
original amount to be reduced by 50%
Why is it important to know the half-life of a drug? - (ANSWER)-to help
determine dosing intervals to maintain therapeutic levels
What is the first-pass effect? - (ANSWER)-alteration of the drug dose by
metabolism before it reaches systemic circulation
-only happens with PO medications
What are the genetic variances of metabolism? - (ANSWER)-poor metabolizers
(certain enzymes are little to none)
-intermediate metabolizers
-extensive metabolizers (NORMAL)
-ultra-rapid metabolizers (duplicate genes to make extra enzymes)
Complete Questions and Correct Detailed Answers
What is prescriptive authority? - (ANSWER)Legal right to prescribe drugs
Is the Physicians Desk Reference a reliable source to use when prescribing drugs?
- (ANSWER)No--it is not evidence-based and it is not updated
What is the sunshine act? - (ANSWER)-part of the affordable care act
-limits providers on accepting gifts from pharmaceutical companies
-reduces bias
What is pharmacology? - (ANSWER)-study of the drugs and their actions and
effects on living things
-legal drugs, illegal drugs, prescription drugs, OTC drugs
How does the FDA define drugs that they approve? - (ANSWER)-chemicals that
have been proved for safety and efficacy
What must providers consider when prescribing? - (ANSWER)-the dose
-the route of administration
-indications
-side effects of consequence
-adverse effects
,-contraindications
-significant drug-drug interactions
-appropriate monitoring
-treatment of side effects if necessary
What is pharmacokinetics? - (ANSWER)-how drugs move in the body and what
the body does with it
How does pharmacokinetics influence prescribing? - (ANSWER)-the route
-the dosage needed
-dosing intervals
What are the 4 aspects of pharmacokinetics? - (ANSWER)-absorption
-distribution
-metabolism
-excretion
What affects bioavailability the most? - (ANSWER)PO administration
What is a pro-drug? - (ANSWER)-a drug that needs to be metabolized to become
"activated"
, What is the major organ of metabolism? - (ANSWER)-Liver
-Uses enzymes called "CYPs"
-these enzymes can induce or inhibit metabolism
What is protein-binding? - (ANSWER)-drugs that have a high affinity for proteins
will bind with them and therefore become unable to bind to receptor sites
-in order to activate receptors they must be free circulating molecules
What is the half-life of a drug? - (ANSWER)-how long it takes for a drug at its
original amount to be reduced by 50%
Why is it important to know the half-life of a drug? - (ANSWER)-to help
determine dosing intervals to maintain therapeutic levels
What is the first-pass effect? - (ANSWER)-alteration of the drug dose by
metabolism before it reaches systemic circulation
-only happens with PO medications
What are the genetic variances of metabolism? - (ANSWER)-poor metabolizers
(certain enzymes are little to none)
-intermediate metabolizers
-extensive metabolizers (NORMAL)
-ultra-rapid metabolizers (duplicate genes to make extra enzymes)
