CHE 4342 Chapters 9&10 Part 2&3 Questions With
Complete Solutions
3 Nobel Doctors of 1997, their work, and their share of the
prize? Correct Answers Paul D. Boyer, John E. Walker
discovered mechanism for ATP synthesis. Jens Skou disovered
Na/K pump?ATPase.
1/4, 1/4, 1/2, respectively.
5 Types of ATP pumps: What are their names, what do they do?
Correct Answers A-Type: Pump anions
P-Type: Phosphorylated, pump Na+/K+/Ca++ against gradients.
V-Type: Found in plant vacuoles, pump H+
F-Type: H+ transporting complexes in mitochondria and
bacterial membranes. Operate in reverse to sythesize ATP from
H+ movement down gradient.
ABC-Transporters: ATP=Binding-Cassette Transporters move
ions, small metabolites, and drugs. Associated with bacterial
drug resistance.
Acetylcholinesterase has a catalytic triad and rxn mechanism
similar to what? Correct Answers Serine Protease.
Both have serine residue, O attacks carbonyl C, choline-OH
leaving group.
Takes acetate off acetylcholine.
, Aquaporin structure? Rate of water molecule flow? Any other
solutes/ions? Correct Answers 6 transmembrane alpha helices,
~ 3x10^9 water molecules/sec. NO other solutes/ions pass.
Carrier ionophore vs. Channel-forming ionophore? Antibiotic
properties? Correct Answers Carrier ionophores bind a
specific ion, change conformation, and freely diffuse across the
membrane to release the ion on the other side.
Channel-forming ionophores form a fixed structure pore
allowing free passage of ions. Antibiotic by discharging the ion
gradient.
Diisopropylphospho-fluoride (DIPF) is what? Correct Answers
Nerve gas
Equation for facilitated diffusion (mediated transport) kinetics?
Significance of each variable? Correct Answers Vo =
(Vmax[Sout])/(Kt + [Sout])
Equation for gibbs free energy of uncharged molecule
movement across membrane? Significance of positive or
negative? Correct Answers G=RTln([A2]/[A1])
Negative means energetically favorable, positive means
energetically unfavorable.
Example of a ligand gated ion channel? Correct Answers
acetylcholine receptor ion channel
Complete Solutions
3 Nobel Doctors of 1997, their work, and their share of the
prize? Correct Answers Paul D. Boyer, John E. Walker
discovered mechanism for ATP synthesis. Jens Skou disovered
Na/K pump?ATPase.
1/4, 1/4, 1/2, respectively.
5 Types of ATP pumps: What are their names, what do they do?
Correct Answers A-Type: Pump anions
P-Type: Phosphorylated, pump Na+/K+/Ca++ against gradients.
V-Type: Found in plant vacuoles, pump H+
F-Type: H+ transporting complexes in mitochondria and
bacterial membranes. Operate in reverse to sythesize ATP from
H+ movement down gradient.
ABC-Transporters: ATP=Binding-Cassette Transporters move
ions, small metabolites, and drugs. Associated with bacterial
drug resistance.
Acetylcholinesterase has a catalytic triad and rxn mechanism
similar to what? Correct Answers Serine Protease.
Both have serine residue, O attacks carbonyl C, choline-OH
leaving group.
Takes acetate off acetylcholine.
, Aquaporin structure? Rate of water molecule flow? Any other
solutes/ions? Correct Answers 6 transmembrane alpha helices,
~ 3x10^9 water molecules/sec. NO other solutes/ions pass.
Carrier ionophore vs. Channel-forming ionophore? Antibiotic
properties? Correct Answers Carrier ionophores bind a
specific ion, change conformation, and freely diffuse across the
membrane to release the ion on the other side.
Channel-forming ionophores form a fixed structure pore
allowing free passage of ions. Antibiotic by discharging the ion
gradient.
Diisopropylphospho-fluoride (DIPF) is what? Correct Answers
Nerve gas
Equation for facilitated diffusion (mediated transport) kinetics?
Significance of each variable? Correct Answers Vo =
(Vmax[Sout])/(Kt + [Sout])
Equation for gibbs free energy of uncharged molecule
movement across membrane? Significance of positive or
negative? Correct Answers G=RTln([A2]/[A1])
Negative means energetically favorable, positive means
energetically unfavorable.
Example of a ligand gated ion channel? Correct Answers
acetylcholine receptor ion channel
