N617 Pharmacology Exam 2 –Jean Genzale – Complete Study Guide
with Review Questions
A pediatric patient who weighs 30lbs is prescribed Prednisolone 1.5mg / kg / day as a " burst
therapy " for asthma exacerbation . Please calculate a dose in whole number of mg for a total
daily dose of Prednisolone - correct answer 20
All of the following therapies are used as acute therapy for a cluster headache except
a . Intranasal lidocaine
b . Intranasal sumatriptan ( imitrex )
c . Ergotamine derivative
d . Verapamil - correct answer d . Verapamil
A disadvantage to the use of nicotinic acid ( niacin ) for hyperlipidemia is ?
a . It is associated with constipation
b . it may cause a life - threatening myopathy
c . It commonly produces flushing in the face and neck area
d . It will decrease the absorption of other oral drugs given simultaneously - correct answer c . It
commonly produces flushing in the face and neck area
All of the following respiratory agents are safe to use in pregnancy except
a . brompheniramine ( dimetane )
b . potassium iodide
c . hydrocortisone
d . dextromethorphan ( Delsym ) - correct answer b . potassium iodide
antihistamines have antagonistic activity on cholinergic receptors leading to anticholinergic
adverse effects . Examples of anticholinergic adverse effects include
a . bronchospasm
b . nasal stuffiness
c . pruritus
d . tachycardia - correct answer d . tachycardia
,beta blockers are used therapeutically in patients with angina
a . decrease the time allowed for coronary blood flow
b . increase cardiac output
C. increase the time that the heart is in diastole
d . increase myocardial oxygen consumption - correct answer C. increase the time that the
heart is in diastole
although most asthmatics are controlled with a combination of medications , the class that
provides the most effective bronchodilation is ?
a . Anticholinergic inhalants
b . Beta 2 adrenergic agents
C. Cromones
d . Methylxanthines - correct answer b . Beta 2 adrenergic agents
Angiotensin II receptor antagonists ( ARBS )
a . May be prescribed to pregnant women without fear of causing fetal harm
b . Are excreted both in the urine and the bile
C.Have limited use due to multiple adverse effects
d . Commonly cause a persistent cough as an adverse drug reaction - correct answer b . Are
excreted both in the urine and the bile
According to the textbook , preferred step 4 treatment for persistent asthma in 12 y / o
children and adults is
a . Cromolyn
b . Low dose ICS
C. Medium dose ICS
d . Medium dose ICS + LABA - correct answer d . Medium dose ICS + LABA
Although most antiemetics also produce sedation , which of the following is the least likely to
have this effect
a . Dronabinol ( marinol )
b . Ondansetron ( zofran )
C. Promethazine ( Phenergan )
,d . Trimethobenzamide ( Tigan ) - correct answer b . Ondansetron ( zofran )
Beta blockers must be used with caution in patients who have heart failure . Which of the
following statements describe possible consequences of slowing the heart rate in a patient with
HF ?
a . May increase perfusion of coronary arteries
b . May increase cardiac contractility
C. May increase myocardial oxygen supply
d . May decrease cardiac output to a critical level - correct answer d . May decrease cardiac
output to a critical level
Bile acid sequestrants
a . Are all considered pregnancy category D
b . Are activated from a prodrug to an active form in the liver
c . Reduce the amount of cholesterol stored in adipose tissue
d . Require close monitoring of hepatic function - correct answer c . Reduce the amount of
cholesterol stored in adipose tissue
Chlamydial pneumonia should be treated with the following suggested antimicrobial ?
a. Amoxicillin ( Amoxil )
b . Amoxicillin - clavulanate ( Augmentin )
c . Azithromycin ( Zithromax )
d . Ceftriaxone ( rocephin ) - correct answer c . Azithromycin ( Zithromax )
Calcium channel blockers
a . Block calcium channels inayocardial cells resulting in decreased myocardial contraction
b . Cause increased heart rate by speeding conductance of electrical cells
C. Decrease calcium movement into the extracellular environment
d . Have negative effects on glucose levels in diabetic patients - correct answer a . Block calcium
channels inayocardial cells resulting in decreased myocardial contraction
Centrally acting alpha II adrenergic agents
a . Interact with alpha II receptors on the peripheral vascular system
b . Increases venous return ; thereby decreasing heart rate
, C. Result in a mild to moderate increase in cardiac output
d . Result in vasodilation leading to a decrease in blood pressure - correct answer b . Increases
venous return ; thereby decreasing heart rate
Dobutamine in the treatment of acute CHF
a. Can be given sublingually
b . Increases the force of myocardial contraction
C. Reduces systemic vascular resistance and decreases afterload
d . Works as a beta agonist and an alpha agonist - correct answer b . Increases the force of
myocardial contraction
Direct acting vasodilators
a . Are teratogenic
b . Block the action of aldosterone
c . Can be useful in the treatment of hypertensive crisis
d . Often cause impotence in men - correct answer c . Can be useful in the treatment of
hypertensive crisis
Electrolyte depletion is most likely to occur with which of the following laxatives
a . Bisacodyl ( doculax )
b . Mineral oil
c . Psyllium ( Metamucil )
d . Sodium docusate ( Colace ) - correct answer a . Bisacodyl ( doculax )
Hyperkalemia is a side effect of which of the following drugs
a . Chlorthalidone ( Hgroton )
b . Furosemide ( Lasix )
c . Hydrochlorothiazide ( Hydrodiuril )
d . Spironolactone ( Aldactone ) - correct answer d . Spironolactone ( Aldactone )
Inhalational formations of a drug are absorbed very quickly because
a There are no natural defenses against inhaled particles
b . Of the enormous blood supply at the alveolar capillary membranes
with Review Questions
A pediatric patient who weighs 30lbs is prescribed Prednisolone 1.5mg / kg / day as a " burst
therapy " for asthma exacerbation . Please calculate a dose in whole number of mg for a total
daily dose of Prednisolone - correct answer 20
All of the following therapies are used as acute therapy for a cluster headache except
a . Intranasal lidocaine
b . Intranasal sumatriptan ( imitrex )
c . Ergotamine derivative
d . Verapamil - correct answer d . Verapamil
A disadvantage to the use of nicotinic acid ( niacin ) for hyperlipidemia is ?
a . It is associated with constipation
b . it may cause a life - threatening myopathy
c . It commonly produces flushing in the face and neck area
d . It will decrease the absorption of other oral drugs given simultaneously - correct answer c . It
commonly produces flushing in the face and neck area
All of the following respiratory agents are safe to use in pregnancy except
a . brompheniramine ( dimetane )
b . potassium iodide
c . hydrocortisone
d . dextromethorphan ( Delsym ) - correct answer b . potassium iodide
antihistamines have antagonistic activity on cholinergic receptors leading to anticholinergic
adverse effects . Examples of anticholinergic adverse effects include
a . bronchospasm
b . nasal stuffiness
c . pruritus
d . tachycardia - correct answer d . tachycardia
,beta blockers are used therapeutically in patients with angina
a . decrease the time allowed for coronary blood flow
b . increase cardiac output
C. increase the time that the heart is in diastole
d . increase myocardial oxygen consumption - correct answer C. increase the time that the
heart is in diastole
although most asthmatics are controlled with a combination of medications , the class that
provides the most effective bronchodilation is ?
a . Anticholinergic inhalants
b . Beta 2 adrenergic agents
C. Cromones
d . Methylxanthines - correct answer b . Beta 2 adrenergic agents
Angiotensin II receptor antagonists ( ARBS )
a . May be prescribed to pregnant women without fear of causing fetal harm
b . Are excreted both in the urine and the bile
C.Have limited use due to multiple adverse effects
d . Commonly cause a persistent cough as an adverse drug reaction - correct answer b . Are
excreted both in the urine and the bile
According to the textbook , preferred step 4 treatment for persistent asthma in 12 y / o
children and adults is
a . Cromolyn
b . Low dose ICS
C. Medium dose ICS
d . Medium dose ICS + LABA - correct answer d . Medium dose ICS + LABA
Although most antiemetics also produce sedation , which of the following is the least likely to
have this effect
a . Dronabinol ( marinol )
b . Ondansetron ( zofran )
C. Promethazine ( Phenergan )
,d . Trimethobenzamide ( Tigan ) - correct answer b . Ondansetron ( zofran )
Beta blockers must be used with caution in patients who have heart failure . Which of the
following statements describe possible consequences of slowing the heart rate in a patient with
HF ?
a . May increase perfusion of coronary arteries
b . May increase cardiac contractility
C. May increase myocardial oxygen supply
d . May decrease cardiac output to a critical level - correct answer d . May decrease cardiac
output to a critical level
Bile acid sequestrants
a . Are all considered pregnancy category D
b . Are activated from a prodrug to an active form in the liver
c . Reduce the amount of cholesterol stored in adipose tissue
d . Require close monitoring of hepatic function - correct answer c . Reduce the amount of
cholesterol stored in adipose tissue
Chlamydial pneumonia should be treated with the following suggested antimicrobial ?
a. Amoxicillin ( Amoxil )
b . Amoxicillin - clavulanate ( Augmentin )
c . Azithromycin ( Zithromax )
d . Ceftriaxone ( rocephin ) - correct answer c . Azithromycin ( Zithromax )
Calcium channel blockers
a . Block calcium channels inayocardial cells resulting in decreased myocardial contraction
b . Cause increased heart rate by speeding conductance of electrical cells
C. Decrease calcium movement into the extracellular environment
d . Have negative effects on glucose levels in diabetic patients - correct answer a . Block calcium
channels inayocardial cells resulting in decreased myocardial contraction
Centrally acting alpha II adrenergic agents
a . Interact with alpha II receptors on the peripheral vascular system
b . Increases venous return ; thereby decreasing heart rate
, C. Result in a mild to moderate increase in cardiac output
d . Result in vasodilation leading to a decrease in blood pressure - correct answer b . Increases
venous return ; thereby decreasing heart rate
Dobutamine in the treatment of acute CHF
a. Can be given sublingually
b . Increases the force of myocardial contraction
C. Reduces systemic vascular resistance and decreases afterload
d . Works as a beta agonist and an alpha agonist - correct answer b . Increases the force of
myocardial contraction
Direct acting vasodilators
a . Are teratogenic
b . Block the action of aldosterone
c . Can be useful in the treatment of hypertensive crisis
d . Often cause impotence in men - correct answer c . Can be useful in the treatment of
hypertensive crisis
Electrolyte depletion is most likely to occur with which of the following laxatives
a . Bisacodyl ( doculax )
b . Mineral oil
c . Psyllium ( Metamucil )
d . Sodium docusate ( Colace ) - correct answer a . Bisacodyl ( doculax )
Hyperkalemia is a side effect of which of the following drugs
a . Chlorthalidone ( Hgroton )
b . Furosemide ( Lasix )
c . Hydrochlorothiazide ( Hydrodiuril )
d . Spironolactone ( Aldactone ) - correct answer d . Spironolactone ( Aldactone )
Inhalational formations of a drug are absorbed very quickly because
a There are no natural defenses against inhaled particles
b . Of the enormous blood supply at the alveolar capillary membranes
