Test Bank - Cellular and Molecular Immunology,
10th Edition (Abbas, 2022)
1. Infection with HIV results in which of the following?
A. Immunodeficiency
B. Hypersensitivity disease
C. Allergic reaction
D. Autoimmune disease
E. Genetic disorder - ANSWER: immunodeficiency
2. Indicate whether the statement is true or false and explain why.
Booster shots are necessary because repeated exposure to an antigen builds a
stronger immune response. - ANSWER: True, each time the body is exposed
to an antigen the adaptive immune response remembers the antigen a litter
better each time. Therefore, with each subsequent exposure the immune
response reaction time is faster and can more rapidly and easily adapt to fight
the antigen.
3. Indicate whether the statement is true or false and explain why.
Our bodies face the greatest onslaught from foreign invaders through the skin. -
ANSWER: False, most invaders enter the body through the mucous
membranes.
4. The immune system is composed of two "arms" or "branches" - the innate and
the adaptive. Both branches operate completely independent on one another and
there are no shared cell types between them.
True or False? - ANSWER: False
5. Conditions in which the immune system attacks self-antigens are known as: -
ANSWER: autoimmune
6. Which of the following cell types are lymphocytes?
A. Neutrophils
B. Erythrocytes
C. Mast cells
D. Macrophages
E. T cells - ANSWER: T cells
7. Which of the following is the BEST example of a hypersensitivity reaction?
,Test Bank - Cellular and Molecular Immunology,
10th Edition (Abbas, 2022)
A. T cells responding vigorously to the flu virus
B. T cells attacking the myelin sheath of nerves resulting in paralysis
C. Anemia as a result of iron deficiency
D. Inflammation of the airways in response to pollen
E. B cells failing to respond to HIV allowing it to replicate out of control -
ANSWER: inflammation of the airways in response to pollen
8. __________ involves the use of antibodies to fight pathogens. Antibodies are
produced by B-cells and can be found in body fluids. - ANSWER: Humoral
9. All blood cells in an adult human can trace their ancestry to which compartment
within the body?
A. Thymus
B. Bone marrow
C. Lymph node
D. Peyer's patch
E. Spleen - ANSWER: bone marrow
10. From which of the following stem cells are DCs derived?
A. CLP
B. CMP
C. CEP
D. Both A and B
E. A, B, and C - ANSWER: CLP and CMP
11. What level of gene expression is regulated by such factors as Notch1, GATA-2,
and Bmi-1?
A. Replication
B. Transcription
C. RNA processing
D. Translation
E. Regulation - ANSWER: transcription
12. Which of the following is NOT descended from the common lymphoid progenitor?
A. T cells
B. NK cells
C. B cells
D. Eosinophils - ANSWER: eosinophils
,Test Bank - Cellular and Molecular Immunology,
10th Edition (Abbas, 2022)
13. A cell is isolated from secondary lymphoid tissue. The cell has the following
surface markers: CD2, CD8, CD45, and CD56. This cell is:
A. B cell
B. TH cell
C. TC cell
D. NK cell
E. Either TH cell or TC cell - ANSWER: NK cell
14. Which about the spleen is false:
A. It filters blood
B. It defends by initiating macrophages to remove microorganisms in blood
and phagocytose them
C. Contains red pulp, white pulp, and marginal zones
D. It is the source of lymphocytes before birth and enables lymphocytes to
develop into T cells - ANSWER: it is the source of lymphocytes before
birth and enables lymphocytes to develop into T cells
15. Name the macrophage associated with the liver: - ANSWER: Kupffer cell
16. Name 3 antigen-presenting cells: - ANSWER: 1. monocytes
2. macrophages
3. dendritic cells
17. IL-2 acts on several cell types thus regulating multiple immune processes. IL-2 is
said to be:
A. Antagonistic
B. Cascade inducible
C. Pleiotropic
D. Redundant
E. Synergistic - ANSWER: pleiotropic
18. Which of the following is associated with preventing (or stopping) viral infection?
A. TNF-α
B. IL-2
C. IL-4
D. INF-α
E. All of the above - ANSWER: INF-α
, Test Bank - Cellular and Molecular Immunology,
10th Edition (Abbas, 2022)
19. Which of the following are not associated with inflammation caused by tissue
injury?
A. Vasodilation occurs in response to cytokines that is released by damaged
cells
B. Antibodies are produced by B cells
C. The passage of neutrophils through capillary walls
D. Endothelial cells begin expressing surface molecules that allow for
interaction with neutrophils, a process referred to as a margination -
ANSWER: antibodies are produced by B cells
20. Which of the following is the CORRECT relationship? __________ on
__________ recognize __________ on __________
A. PRRs; macrophages; PAMPs; pathogens
B. PRRs; pathogens; PAMPs; macrophages
C. PAMPs; macrophages; PRRs; pathogens
D. PAMPs; neutrophils; PRRs; pathogens
E. PRRs; macrophages; PAMPs; neutrophils - ANSWER: PRRs;
macrophages; PAMPs; pathogens
21. Name a cell of the innate immune system that is phagocytic? - ANSWER:
neutrophil
22. A person with genetic defects in genes associated TLR 7 and 8 would most likely
be more susceptible to which of the following?
A. Mycobacterium spp. infections
B. Parasitic worm infections
C. DNA virus infections
D. RNA virus infections - ANSWER: RNA virus infections
23. Name three human organs or areas of the body where you would expect to find
significant levels of antimicrobial proteins.
- ANSWER: 1. skin
2. mucous membranes
3. respiratory tract
24. Define cytokine. - ANSWER: proteins that regulate the immune response
25. Select the leukocyte that is best described by each statement.
10th Edition (Abbas, 2022)
1. Infection with HIV results in which of the following?
A. Immunodeficiency
B. Hypersensitivity disease
C. Allergic reaction
D. Autoimmune disease
E. Genetic disorder - ANSWER: immunodeficiency
2. Indicate whether the statement is true or false and explain why.
Booster shots are necessary because repeated exposure to an antigen builds a
stronger immune response. - ANSWER: True, each time the body is exposed
to an antigen the adaptive immune response remembers the antigen a litter
better each time. Therefore, with each subsequent exposure the immune
response reaction time is faster and can more rapidly and easily adapt to fight
the antigen.
3. Indicate whether the statement is true or false and explain why.
Our bodies face the greatest onslaught from foreign invaders through the skin. -
ANSWER: False, most invaders enter the body through the mucous
membranes.
4. The immune system is composed of two "arms" or "branches" - the innate and
the adaptive. Both branches operate completely independent on one another and
there are no shared cell types between them.
True or False? - ANSWER: False
5. Conditions in which the immune system attacks self-antigens are known as: -
ANSWER: autoimmune
6. Which of the following cell types are lymphocytes?
A. Neutrophils
B. Erythrocytes
C. Mast cells
D. Macrophages
E. T cells - ANSWER: T cells
7. Which of the following is the BEST example of a hypersensitivity reaction?
,Test Bank - Cellular and Molecular Immunology,
10th Edition (Abbas, 2022)
A. T cells responding vigorously to the flu virus
B. T cells attacking the myelin sheath of nerves resulting in paralysis
C. Anemia as a result of iron deficiency
D. Inflammation of the airways in response to pollen
E. B cells failing to respond to HIV allowing it to replicate out of control -
ANSWER: inflammation of the airways in response to pollen
8. __________ involves the use of antibodies to fight pathogens. Antibodies are
produced by B-cells and can be found in body fluids. - ANSWER: Humoral
9. All blood cells in an adult human can trace their ancestry to which compartment
within the body?
A. Thymus
B. Bone marrow
C. Lymph node
D. Peyer's patch
E. Spleen - ANSWER: bone marrow
10. From which of the following stem cells are DCs derived?
A. CLP
B. CMP
C. CEP
D. Both A and B
E. A, B, and C - ANSWER: CLP and CMP
11. What level of gene expression is regulated by such factors as Notch1, GATA-2,
and Bmi-1?
A. Replication
B. Transcription
C. RNA processing
D. Translation
E. Regulation - ANSWER: transcription
12. Which of the following is NOT descended from the common lymphoid progenitor?
A. T cells
B. NK cells
C. B cells
D. Eosinophils - ANSWER: eosinophils
,Test Bank - Cellular and Molecular Immunology,
10th Edition (Abbas, 2022)
13. A cell is isolated from secondary lymphoid tissue. The cell has the following
surface markers: CD2, CD8, CD45, and CD56. This cell is:
A. B cell
B. TH cell
C. TC cell
D. NK cell
E. Either TH cell or TC cell - ANSWER: NK cell
14. Which about the spleen is false:
A. It filters blood
B. It defends by initiating macrophages to remove microorganisms in blood
and phagocytose them
C. Contains red pulp, white pulp, and marginal zones
D. It is the source of lymphocytes before birth and enables lymphocytes to
develop into T cells - ANSWER: it is the source of lymphocytes before
birth and enables lymphocytes to develop into T cells
15. Name the macrophage associated with the liver: - ANSWER: Kupffer cell
16. Name 3 antigen-presenting cells: - ANSWER: 1. monocytes
2. macrophages
3. dendritic cells
17. IL-2 acts on several cell types thus regulating multiple immune processes. IL-2 is
said to be:
A. Antagonistic
B. Cascade inducible
C. Pleiotropic
D. Redundant
E. Synergistic - ANSWER: pleiotropic
18. Which of the following is associated with preventing (or stopping) viral infection?
A. TNF-α
B. IL-2
C. IL-4
D. INF-α
E. All of the above - ANSWER: INF-α
, Test Bank - Cellular and Molecular Immunology,
10th Edition (Abbas, 2022)
19. Which of the following are not associated with inflammation caused by tissue
injury?
A. Vasodilation occurs in response to cytokines that is released by damaged
cells
B. Antibodies are produced by B cells
C. The passage of neutrophils through capillary walls
D. Endothelial cells begin expressing surface molecules that allow for
interaction with neutrophils, a process referred to as a margination -
ANSWER: antibodies are produced by B cells
20. Which of the following is the CORRECT relationship? __________ on
__________ recognize __________ on __________
A. PRRs; macrophages; PAMPs; pathogens
B. PRRs; pathogens; PAMPs; macrophages
C. PAMPs; macrophages; PRRs; pathogens
D. PAMPs; neutrophils; PRRs; pathogens
E. PRRs; macrophages; PAMPs; neutrophils - ANSWER: PRRs;
macrophages; PAMPs; pathogens
21. Name a cell of the innate immune system that is phagocytic? - ANSWER:
neutrophil
22. A person with genetic defects in genes associated TLR 7 and 8 would most likely
be more susceptible to which of the following?
A. Mycobacterium spp. infections
B. Parasitic worm infections
C. DNA virus infections
D. RNA virus infections - ANSWER: RNA virus infections
23. Name three human organs or areas of the body where you would expect to find
significant levels of antimicrobial proteins.
- ANSWER: 1. skin
2. mucous membranes
3. respiratory tract
24. Define cytokine. - ANSWER: proteins that regulate the immune response
25. Select the leukocyte that is best described by each statement.
