ANCC FNP Board Exam Study Guide
Part 1 Questions and Answers | Latest
Version | 2025/2026 | Correct & Verified
What is the first-line treatment for newly diagnosed hypertension in a 45-year-old African
American male with no other comorbidities?
✔✔Thiazide diuretic or calcium channel blocker
What lab test should be ordered to monitor the effects of an ACE inhibitor?
✔✔Serum creatinine and potassium
Which vaccine is contraindicated in pregnancy?
✔✔MMR (measles, mumps, rubella)
What is the most appropriate next step in managing a child with a positive strep throat test and a
penicillin allergy?
✔✔Prescribe azithromycin
Which medication class is most associated with causing ankle edema?
1
,✔✔Calcium channel blockers
What is the best initial diagnostic test for suspected hypothyroidism?
✔✔TSH
What is the recommended screening interval for a Pap smear in a 30-year-old female with
normal cytology and HPV co-testing?
✔✔Every 5 years
What is the likely diagnosis in a patient with tremor at rest, bradykinesia, and a shuffling gait?
✔✔Parkinson’s disease
What is the most common cause of chronic cough in non-smokers?
✔✔Postnasal drip
What is the gold standard test for diagnosing diabetes?
✔✔Fasting plasma glucose ≥126 mg/dL on two separate occasions
2
,What is the most appropriate treatment for acute otitis media in a child who is not allergic to
penicillin?
✔✔Amoxicillin
What is the initial management for a patient with suspected pulmonary embolism and
hemodynamic stability?
✔✔CT pulmonary angiography
What is the primary lifestyle modification recommended for managing GERD symptoms?
✔✔Elevate the head of the bed
What test confirms a diagnosis of mononucleosis?
✔✔Monospot test
What condition is characterized by sudden onset of severe headache and neck stiffness?
✔✔Subarachnoid hemorrhage
What is the first-line pharmacologic treatment for generalized anxiety disorder?
3
, ✔✔SSRIs
What is the best screening test for colorectal cancer in average-risk adults starting at age 45?
✔✔Colonoscopy every 10 years
What finding is most concerning in a patient with suspected malignant melanoma?
✔✔Asymmetry, irregular borders, color variation, diameter >6mm, evolving lesion
What medication is commonly used for smoking cessation and also has antidepressant
properties?
✔✔Bupropion
What is the next step when a patient on warfarin has an INR of 8.0 without bleeding?
✔✔Hold warfarin and administer vitamin K
What is the most appropriate management for asymptomatic bacteriuria in a pregnant woman?
✔✔Treat with antibiotics
4
Part 1 Questions and Answers | Latest
Version | 2025/2026 | Correct & Verified
What is the first-line treatment for newly diagnosed hypertension in a 45-year-old African
American male with no other comorbidities?
✔✔Thiazide diuretic or calcium channel blocker
What lab test should be ordered to monitor the effects of an ACE inhibitor?
✔✔Serum creatinine and potassium
Which vaccine is contraindicated in pregnancy?
✔✔MMR (measles, mumps, rubella)
What is the most appropriate next step in managing a child with a positive strep throat test and a
penicillin allergy?
✔✔Prescribe azithromycin
Which medication class is most associated with causing ankle edema?
1
,✔✔Calcium channel blockers
What is the best initial diagnostic test for suspected hypothyroidism?
✔✔TSH
What is the recommended screening interval for a Pap smear in a 30-year-old female with
normal cytology and HPV co-testing?
✔✔Every 5 years
What is the likely diagnosis in a patient with tremor at rest, bradykinesia, and a shuffling gait?
✔✔Parkinson’s disease
What is the most common cause of chronic cough in non-smokers?
✔✔Postnasal drip
What is the gold standard test for diagnosing diabetes?
✔✔Fasting plasma glucose ≥126 mg/dL on two separate occasions
2
,What is the most appropriate treatment for acute otitis media in a child who is not allergic to
penicillin?
✔✔Amoxicillin
What is the initial management for a patient with suspected pulmonary embolism and
hemodynamic stability?
✔✔CT pulmonary angiography
What is the primary lifestyle modification recommended for managing GERD symptoms?
✔✔Elevate the head of the bed
What test confirms a diagnosis of mononucleosis?
✔✔Monospot test
What condition is characterized by sudden onset of severe headache and neck stiffness?
✔✔Subarachnoid hemorrhage
What is the first-line pharmacologic treatment for generalized anxiety disorder?
3
, ✔✔SSRIs
What is the best screening test for colorectal cancer in average-risk adults starting at age 45?
✔✔Colonoscopy every 10 years
What finding is most concerning in a patient with suspected malignant melanoma?
✔✔Asymmetry, irregular borders, color variation, diameter >6mm, evolving lesion
What medication is commonly used for smoking cessation and also has antidepressant
properties?
✔✔Bupropion
What is the next step when a patient on warfarin has an INR of 8.0 without bleeding?
✔✔Hold warfarin and administer vitamin K
What is the most appropriate management for asymptomatic bacteriuria in a pregnant woman?
✔✔Treat with antibiotics
4
