Advanced Pathophysiology Exam II Review
Study online at https://quizlet.com/_e3u3ob
1. What is the risk of a woman with a first degree The woman's risk doubles
relative with breast cancer developing breast
cancer herself?
2. During the inflammatory process, what caus- Increased capillary permeability
es edema?
3. What are the outcomes of the complement 1. anaphylatoxic activity resulting in
cascade mast cell degranulation
2. leukocyte chemotaxis
3. opsonization
4. cell lysis
4. What is the role of the NK cells? Elimination of malignant cells
5. What is the role of eosinophils in regulating Release of histaminase that limits the ef-
vascular mediators released from mast cells? fects of histamine during inflammation
6. What is the predominant phagocytic cell in Monocytes
the later stages of an inflammatory response?
7. Which chemical mediator derived from mast Platelet-activating factor (PAF)
cells retracts endothelial cells to increase vas-
cular permeability and causes leukocyte ad-
hesion to endothelial cells?
8. Which cytokine is needed for the maturation Interleukin-2 (IL-2)
of a functional Helper-T cell?
9. Define hypersensitivity an altered immunological response to
an antigen that results in disease or
damage to the host
10. IgE (Type I reaction)
1/7
, Advanced Pathophysiology Exam II Review
Study online at https://quizlet.com/_e3u3ob
What is the mediator for a common hay fever
allergy?
11. The class of antibody involved in type I hyper- IgE
sensitivity reactions
12. What type of immunity is exemplified by a alloimmunity
blood transfusion
13. During an IgE-mediated hypersensitivity reac- Eosinophils
tion, which leukocyte is activated?
14. During an IgE mediated hypersensitivity reac- Smooth muscle contraction caused by
tion, what causes bronchospasam? histamine bound to H1 receptors
15. During an IgE-mediated hypersensitivity reac- 1 molecule of the antigen bind simulta-
tion, the degranulation of mast cells is a result neously to 2 molecules of IgE-Fc recep-
of what action? tor complexes on the mast cell surface
resulting in the activation of interacel-
lular signaling pathways and mast cell
granulation
16. In a type II hypersensitivity reaction, when Neutrophil granules and toxic oxygen
soluble antigens from infectious agents enter products
circulation, what causes tissue damage?
17. What is the mechanism in type III hypersensi- Antibodies bind to soluble antigens that
tivity reactions? were released into the body fluids and
immune complexes are deposited in the
tissue
18. What is the mechanism in type IV hypersensi- Cytotoxic T lyphocytes or lymphokine
tivity reactions? producing T1 cells attacking and de-
stroying cellular targets directly
2/7
Study online at https://quizlet.com/_e3u3ob
1. What is the risk of a woman with a first degree The woman's risk doubles
relative with breast cancer developing breast
cancer herself?
2. During the inflammatory process, what caus- Increased capillary permeability
es edema?
3. What are the outcomes of the complement 1. anaphylatoxic activity resulting in
cascade mast cell degranulation
2. leukocyte chemotaxis
3. opsonization
4. cell lysis
4. What is the role of the NK cells? Elimination of malignant cells
5. What is the role of eosinophils in regulating Release of histaminase that limits the ef-
vascular mediators released from mast cells? fects of histamine during inflammation
6. What is the predominant phagocytic cell in Monocytes
the later stages of an inflammatory response?
7. Which chemical mediator derived from mast Platelet-activating factor (PAF)
cells retracts endothelial cells to increase vas-
cular permeability and causes leukocyte ad-
hesion to endothelial cells?
8. Which cytokine is needed for the maturation Interleukin-2 (IL-2)
of a functional Helper-T cell?
9. Define hypersensitivity an altered immunological response to
an antigen that results in disease or
damage to the host
10. IgE (Type I reaction)
1/7
, Advanced Pathophysiology Exam II Review
Study online at https://quizlet.com/_e3u3ob
What is the mediator for a common hay fever
allergy?
11. The class of antibody involved in type I hyper- IgE
sensitivity reactions
12. What type of immunity is exemplified by a alloimmunity
blood transfusion
13. During an IgE-mediated hypersensitivity reac- Eosinophils
tion, which leukocyte is activated?
14. During an IgE mediated hypersensitivity reac- Smooth muscle contraction caused by
tion, what causes bronchospasam? histamine bound to H1 receptors
15. During an IgE-mediated hypersensitivity reac- 1 molecule of the antigen bind simulta-
tion, the degranulation of mast cells is a result neously to 2 molecules of IgE-Fc recep-
of what action? tor complexes on the mast cell surface
resulting in the activation of interacel-
lular signaling pathways and mast cell
granulation
16. In a type II hypersensitivity reaction, when Neutrophil granules and toxic oxygen
soluble antigens from infectious agents enter products
circulation, what causes tissue damage?
17. What is the mechanism in type III hypersensi- Antibodies bind to soluble antigens that
tivity reactions? were released into the body fluids and
immune complexes are deposited in the
tissue
18. What is the mechanism in type IV hypersensi- Cytotoxic T lyphocytes or lymphokine
tivity reactions? producing T1 cells attacking and de-
stroying cellular targets directly
2/7
