Chamberlain NR507 Midterm Exam – Latest 2025
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Terms in this set (63)
- "Allergic reaction"
- Mediated by IgE.
- Inflammation d/t mast cell degranulation.
- Hay fever, hives (uticaria).
Type 1 Hypersensitivity
- Local s/s: itching, rash.
Reaction
- Systemic: wheezing.
- Severe, systemic reaction: anaphylaxis: hypotension,
severe bronchoconstriction.
- Main tx: epinephrine.
- Cytotoxic reaction; tissue specific
- Macrophages are the primary effectors cells
involved
- Causes tissue damage or alters function
Type 2 Hypersensitivity - Examples: 1) Grave's disease- example of altering
Reaction thyroid function, doesn't destroy thyroid tissue. 2)
ABO incompatibility- example of cell/tissue damage;
severe transfusion reaction occurs & the transfused
erythrocytes are destroyed by agglutination or
complement-mediated lysis.
, - Type 2: organ specific; antibody binds to the antigen
on the cell surface.
Difference between type
- Type 3: not organ specific; antibody binds to soluble
2 & 3 hypersensitivity
antigen outside the cell surface that was released into
reactions
the blood or body fluids, and the complex is then
deposited in the tissues.
- Immune complex
- Antigen-antibody complex deposited in the tissues
Type 3 Hypersensitivity - Neutrophils are the primary effector cell
Reaction - Causes autoimmune diseases
- Examples: rheumatoid arthritis ( joints), systemic
lupus erythematosus (SLE, organs)
- Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- Photosensitivity (skin rash d/t sunlight exposure)
- Oral or nasopharyngeal ulcers
- Hematologic disorders (hemolytic anemia,
Systemic Lupus leukopenia, lymphopenia, thrombocytopenia)
Erythematosus (SLE) - Immunologic disorders
- Non-erosive arthritis of at least two peripheral joints
- Serositis (pleurisy, pericarditis)
- Renal disorder
- Neurologic disorders (seizures, psychosis)
- Presence of antinuclear antibody (ANA)
- Can be familial: Affected family members may not all
develop the same disease, but several members may
Autoimmunity have different disorders characterized by a variety of
hypersensitivity reactions (autoimmune and allergic
reactions).
Version | with Questions and Correct Answers |
Verified & Graded A+
Save
Terms in this set (63)
- "Allergic reaction"
- Mediated by IgE.
- Inflammation d/t mast cell degranulation.
- Hay fever, hives (uticaria).
Type 1 Hypersensitivity
- Local s/s: itching, rash.
Reaction
- Systemic: wheezing.
- Severe, systemic reaction: anaphylaxis: hypotension,
severe bronchoconstriction.
- Main tx: epinephrine.
- Cytotoxic reaction; tissue specific
- Macrophages are the primary effectors cells
involved
- Causes tissue damage or alters function
Type 2 Hypersensitivity - Examples: 1) Grave's disease- example of altering
Reaction thyroid function, doesn't destroy thyroid tissue. 2)
ABO incompatibility- example of cell/tissue damage;
severe transfusion reaction occurs & the transfused
erythrocytes are destroyed by agglutination or
complement-mediated lysis.
, - Type 2: organ specific; antibody binds to the antigen
on the cell surface.
Difference between type
- Type 3: not organ specific; antibody binds to soluble
2 & 3 hypersensitivity
antigen outside the cell surface that was released into
reactions
the blood or body fluids, and the complex is then
deposited in the tissues.
- Immune complex
- Antigen-antibody complex deposited in the tissues
Type 3 Hypersensitivity - Neutrophils are the primary effector cell
Reaction - Causes autoimmune diseases
- Examples: rheumatoid arthritis ( joints), systemic
lupus erythematosus (SLE, organs)
- Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- Photosensitivity (skin rash d/t sunlight exposure)
- Oral or nasopharyngeal ulcers
- Hematologic disorders (hemolytic anemia,
Systemic Lupus leukopenia, lymphopenia, thrombocytopenia)
Erythematosus (SLE) - Immunologic disorders
- Non-erosive arthritis of at least two peripheral joints
- Serositis (pleurisy, pericarditis)
- Renal disorder
- Neurologic disorders (seizures, psychosis)
- Presence of antinuclear antibody (ANA)
- Can be familial: Affected family members may not all
develop the same disease, but several members may
Autoimmunity have different disorders characterized by a variety of
hypersensitivity reactions (autoimmune and allergic
reactions).
