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NR 507 Week 2 – Cardiovascular System Pathophysiology Study Guide and Practice Questions (Chamberlain 2025/2026)

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NR 507 Week 2 – Cardiovascular System Pathophysiology Study Guide and Practice Questions (Chamberlain 2025/2026)

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August 1, 2025
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Written in
2025/2026
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atherosclerosis and affects the heart by obstructing the supply of oxygenated blood,
Coronary artery disease (CAD) is caused by altering myocardial cell metabolism and nutrient uptake.


The progression of plaque build-up in the resistance, lessening the ability for oxygenated blood and nutrients to flow through, and
can lead to myocardial ischemia or infarction. ​
arteries causes

htn
DM
Which of the following pathophysiological
condition(s) can lead to coronary artery
disease (CAD)? Select all that apply.​
Heart failure​
Hypertension ​
Atrial fibrillation​
Diabetes mellitus ​
Gastroenteritis ​
Pneumonia​



A buildup of plaque inside a coronary artery leads to reduced circulation to the heart.​



Which of the following statements best
describes the cause of coronary artery
disease (CAD)?​​
A buildup of plaque inside a coronary artery
leads to reduced circulation to the heart.​
Higher than normal blood pressure injures
the inside of the coronary artery, causing
leakage of blood into the heart muscle.​
A clot in the coronary circulation blocks
blood movement beyond a specific point.​​
A heart arrhythmia or disturbance slows the
pumping of the heart, impairing coronary
circulation and reducing oxygenated blood.​​




deoxygenated blood arrives to the ___ right side of the heart

oxygenated blood is carried to the___ The left side of the heart, flowing through the aorta to the body's organs.

the inner layer of the heart endothelial

How does the endothelial prevent placque maintains a balance between vasoconstriction and vasodilation, preventing platelets
from aggregating and controlling fibrin production. ​
buildup

inflammatory processes will occur. Macrophages attach, setting up phagocytosis;
what happens when the endothelium layer plaque formation and vasoconstriction occur, marking the beginning of atherosclerosis.
becomes damaged?


a thrombus, or clot, can form, which disrupts normal blood flow. With disease
progression, myeloid cells can destabilize the plaque in the arterial wall and cause its
what happens as plaque accumulates, rupture, triggering a myocardial infarction (MI) or stroke. ​


Thrombus formation​
Weakened cardiac muscle​
Coronary artery disease (CAD) can lead to Inflammation and plaque accumulation​
which of the following pathophysiological Vasoconstriction ​
conditions? ​Select all that apply.
Vasoconstriction ​
Weakened cardiac muscle​
Thrombus formation​
Inflammation and plaque accumulation​
Inadequate ventilation and perfusion​



when CAD continues and reaching a 1. chronic stable angina or
significant level ___ occurs 2. acute coronary syndrome (ACS) may occur. ​

, 1. unstable angina
2.N-stemi
ACS consists of____ 3. STEMI
4.



preload stretching of the cardiac muscle cells before contraction​

afterload force against the heart or "load" the heart must pump against

Contractability force against the heart or "load" the heart must pump against

stroke volume volume of blood ejected during systole

multiplying the heart rate (beats per minute) times stroke volume; reported in liters per
cardiac output minute​

maintain adequate stroke volume and cardiac output is compromised.​
increased resistance and nutrient
deprivation to myocardial cells may affect
the heart's ability to

CO equation CO= HR X SV

types of fat that travel through the bloodstream and include cholesterol and
lipids triglycerides.

When the body's levels of cholesterol and triglycerides are elevated, the amount of
these fats in the blood increases.
hyperlipidemia, contribute to plaque formation and the risk of developing coronary artery disease
(CAD). ​



1 of 3 risk factors for heart disease HTN, smoking, high cholesterol

chest pressure, pain, or tightness ​
shortness of breath ​
heart palpitations​
fatigue​
epigastric, neck, back, shoulder, or arm pain
indigestion​
Clinical manifestations of coronary artery
diaphoresis​
disease (CAD)
nausea​
lightheadedness or dizziness​




electrocardiogram​​
echocardiogram​​
serum lipid profile​​
exercise stress test​​
chest X-ray​​
cardiac catheterization​
coronary angiogram​
coronary artery calcium scan
dx CAD
CBC
trop
clotting factors




bad cholesterol LDL

good cholesterol HDL

narrowing diameter of at least one coronary artery by atherosclerotic plaques, leading
Ischemia occurs due to to partial or complete obstruction of blood flow.

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