AUTOIMMUNE HEMOLYTIC ANEMIA
Immune hemolytic anemia - correct answer shortened red blood cell (RBC) survival mediated
through the immune response, specifically by humoral antibody
-alloimmune
-autoimmune
-drug-induced - correct answer Three broad categories of immune hemolytic anemias are
ALLOIMMUNE - correct answer patient produces antibodies foreign or nonself RBC antigen
ALLOIMMUNE - correct answer Introduction in circulation by: ➢ Transfusion reaction
➢ Transplantation
➢ Pregnancy (HDFN) - fetus RBC antigen not recognized by mother so it produces antibodies
which attacks antigen of the fetus
Alloimmune - correct answer Safe ang self RBC, ina-attack ang RBC ng donor.
Autoimmune - correct answer The patient produces antibodies directed to SELF against the
individual's own RBC antigens
AUTOIMMUNE - correct answer Most of the autoimmune antibodies produced react with high
incidence RBC antigens. (Sensitize → agglutinate (form lattice formation) → lyse own RBCs and
even random donor.)
AUTOIMMUNE - correct answer Not just attacks own RBC antigen but also act as
alloimmunization and attack nonself RBC antigen
○ But majority attacks own RBC antigen
DRUG-INDUCED - correct answer Drugs that could cause modification to the RBC, WBC and
platelets
WARM AUTOIMMUNE HEMOLYTIC ANEMIA - correct answer Accountfor most cases of AIHA
WARM AUTOIMMUNE HEMOLYTIC ANEMIA - correct answer 70% - 80% of cases of AIHA
IgG - correct answer WARM AUTOIMMUNE HEMOLYTIC ANEMIA
type of antibody
IgG - correct answer - may activate complement and be enhanced by enzyme treatments (ficin,
papain)
, IgG - correct answer - react often with board specificity with Rh blood group system
IgG - correct answer Reacts at 37 °C / warm reacting
AHG Phase - correct answer WARM AUTOIMMUNE HEMOLYTIC ANEMIA
detection
WARM AUTOIMMUNE HEMOLYTIC ANEMIA - correct answer DO NOT directly react/agglutinate
saline suspended RBCs at 37 °C
WARM AUTOIMMUNE HEMOLYTIC ANEMIA - correct answer Reactions/Lattice formation can
be seen much clear in AHG phase
LYMPHOPROLIFERATIVE DISORDERS - correct answer DISEASES FREQUENTLY ASSOCIATED
WITH WAIHA HEMOLYTIC ANEMIA Usually more on
➢ Chronic lymphocytic leukemia
➢ Hodgkin's disease
➢ NonHodgkin's lymphomas
➢ Myelofibrosis
➢ Myelodysplastic syndromes - correct answer Reticuloendothelial neoplasms
➢ Systemic lupus erythematosus
➢ Rheumatoid arthritis - correct answer Collagen disease
Viral syndromes in childhood and adults - correct answer Infectious diseases
➢ Hypogammaglobulinemia
➢ Dysglobulinemia
➢ Other immune-deficiency syndromes - correct answer Immunologic diseases
Ulcerative colitis - correct answer Gastrointestinal diseases
● Carcinoma (nonovarian)
● Pregnancy
● Chronic renal failure - correct answer other diseases
Preventfurther lysis of RBCs - - correct answer TREATMENT FOR WAIHA - Main goal: ____
Immune hemolytic anemia - correct answer shortened red blood cell (RBC) survival mediated
through the immune response, specifically by humoral antibody
-alloimmune
-autoimmune
-drug-induced - correct answer Three broad categories of immune hemolytic anemias are
ALLOIMMUNE - correct answer patient produces antibodies foreign or nonself RBC antigen
ALLOIMMUNE - correct answer Introduction in circulation by: ➢ Transfusion reaction
➢ Transplantation
➢ Pregnancy (HDFN) - fetus RBC antigen not recognized by mother so it produces antibodies
which attacks antigen of the fetus
Alloimmune - correct answer Safe ang self RBC, ina-attack ang RBC ng donor.
Autoimmune - correct answer The patient produces antibodies directed to SELF against the
individual's own RBC antigens
AUTOIMMUNE - correct answer Most of the autoimmune antibodies produced react with high
incidence RBC antigens. (Sensitize → agglutinate (form lattice formation) → lyse own RBCs and
even random donor.)
AUTOIMMUNE - correct answer Not just attacks own RBC antigen but also act as
alloimmunization and attack nonself RBC antigen
○ But majority attacks own RBC antigen
DRUG-INDUCED - correct answer Drugs that could cause modification to the RBC, WBC and
platelets
WARM AUTOIMMUNE HEMOLYTIC ANEMIA - correct answer Accountfor most cases of AIHA
WARM AUTOIMMUNE HEMOLYTIC ANEMIA - correct answer 70% - 80% of cases of AIHA
IgG - correct answer WARM AUTOIMMUNE HEMOLYTIC ANEMIA
type of antibody
IgG - correct answer - may activate complement and be enhanced by enzyme treatments (ficin,
papain)
, IgG - correct answer - react often with board specificity with Rh blood group system
IgG - correct answer Reacts at 37 °C / warm reacting
AHG Phase - correct answer WARM AUTOIMMUNE HEMOLYTIC ANEMIA
detection
WARM AUTOIMMUNE HEMOLYTIC ANEMIA - correct answer DO NOT directly react/agglutinate
saline suspended RBCs at 37 °C
WARM AUTOIMMUNE HEMOLYTIC ANEMIA - correct answer Reactions/Lattice formation can
be seen much clear in AHG phase
LYMPHOPROLIFERATIVE DISORDERS - correct answer DISEASES FREQUENTLY ASSOCIATED
WITH WAIHA HEMOLYTIC ANEMIA Usually more on
➢ Chronic lymphocytic leukemia
➢ Hodgkin's disease
➢ NonHodgkin's lymphomas
➢ Myelofibrosis
➢ Myelodysplastic syndromes - correct answer Reticuloendothelial neoplasms
➢ Systemic lupus erythematosus
➢ Rheumatoid arthritis - correct answer Collagen disease
Viral syndromes in childhood and adults - correct answer Infectious diseases
➢ Hypogammaglobulinemia
➢ Dysglobulinemia
➢ Other immune-deficiency syndromes - correct answer Immunologic diseases
Ulcerative colitis - correct answer Gastrointestinal diseases
● Carcinoma (nonovarian)
● Pregnancy
● Chronic renal failure - correct answer other diseases
Preventfurther lysis of RBCs - - correct answer TREATMENT FOR WAIHA - Main goal: ____
