1|Page
ASCP MLS TEST 2025; ACTUAL TEST
QUESTIONS WITH VERIFIED ANSWERS
What feature is most often found with patients with a splenectomy on a Wright's
stained blood smear? - correct-answer-Howell-Jolly bodies
Which of the following is a characteristic of Factor XII deficiency? - correct-
answer-Negative bleeding history
Patients with a deficiency of factor XII tend to have thrombotic complications. The
do not have bleeding problems most likely due to the lack of activation of fibrin
lysis, also due to pathway activation of IX by VIIa/TF complex as well as the
activation of Factor XI by thrombin
Heinz bodies are: - correct-answer-Denatured hemoglobin inclusions that are
readily removed by the spleen.
Urobilinogen is formed in the: - correct-answer-Intestine
,2|Page
Causes of Vitamin B12 deficiency: - correct-answer-Pericious anemia in relapse,
Patients on chronic hemodialysis and hodgkin disease
T lymphocytes that possess the CD8 surface marker mediate which of the
following T-cell functions? - correct-answer-Cytotoxic T cells, which are capable of
destroying targets such as tumor cells and virus-infected cells, bear the CD8
surface marker, while the other cell types listed ( delayed type hypersensitivity,
regulatory and helper) are positive for the CD4 surface marker
Intrinsic Pathway: - correct-answer-Prekallikrein, heavy molecular weight kinogen,
XII, XI, X, IX, VIII, V, II and I
Measured by APTT
Leukmoid Reaction: - correct-answer-
Vitamin K Factors: - correct-answer-factors II (prothrombin), VII, IX and X.
Anticoagulation proteins: proteins C, S
Christmas Disease: - correct-answer-Deficiency in Factor IX
,3|Page
Amorphous urates is found in: - correct-answer-Acidic pH urine
Amorphous phosphate crystals are found in: - correct-answer-Amorphous
phosphate, triple phosphate (ammonium magnesium phosphate), calcium
phosphate, and ammonium urate crystals are frequently found in alkaline urine
specimens
Which method is the gold standard for ANA detection: - correct-answer-Slide-
based immunofluorescent assay (IFA) or colorzyme
NASBA - correct-answer-Nucleic acid sequence based amplification (NASBA) is a
method in molecular biology which is used to amplify RNA sequences
Used to monitor viral load in HIV paitents
Which condition will show an increased PT with a normal aPTT? - correct-answer-
Factor VII deficiency
, 4|Page
A biomarker with high sensitivity: - correct-answer-accurately identifies the
presence of disease and hos few false-negatives
A biomarker with a high specificity: - correct-answer-accurately detects the
absence of disease and has few false-positives
Leukemoid Reaction Lab Results: - correct-answer-A high white blood cell count,
usually 50-100 x109/L with a left shift is a common finding in leukemoid reactions.
In addition, a key feature of a leukemoid reaction is a high LAP score
Low LAP score: - correct-answer-Paroxysmal Nocturnal Hemoglobinuria, CML
Tay-Sachs Disease: - correct-answer-A rare inherited disorder characterized by the
near-total deficiency of the enzyme N-acetylbetahexosaminidase A.
Term that means varying degree of leukocytosis with a shift to the left and
occasional nucleated red cell in the peripheral blood: - correct-answer-
Leukoerythroblastosis
ASCP MLS TEST 2025; ACTUAL TEST
QUESTIONS WITH VERIFIED ANSWERS
What feature is most often found with patients with a splenectomy on a Wright's
stained blood smear? - correct-answer-Howell-Jolly bodies
Which of the following is a characteristic of Factor XII deficiency? - correct-
answer-Negative bleeding history
Patients with a deficiency of factor XII tend to have thrombotic complications. The
do not have bleeding problems most likely due to the lack of activation of fibrin
lysis, also due to pathway activation of IX by VIIa/TF complex as well as the
activation of Factor XI by thrombin
Heinz bodies are: - correct-answer-Denatured hemoglobin inclusions that are
readily removed by the spleen.
Urobilinogen is formed in the: - correct-answer-Intestine
,2|Page
Causes of Vitamin B12 deficiency: - correct-answer-Pericious anemia in relapse,
Patients on chronic hemodialysis and hodgkin disease
T lymphocytes that possess the CD8 surface marker mediate which of the
following T-cell functions? - correct-answer-Cytotoxic T cells, which are capable of
destroying targets such as tumor cells and virus-infected cells, bear the CD8
surface marker, while the other cell types listed ( delayed type hypersensitivity,
regulatory and helper) are positive for the CD4 surface marker
Intrinsic Pathway: - correct-answer-Prekallikrein, heavy molecular weight kinogen,
XII, XI, X, IX, VIII, V, II and I
Measured by APTT
Leukmoid Reaction: - correct-answer-
Vitamin K Factors: - correct-answer-factors II (prothrombin), VII, IX and X.
Anticoagulation proteins: proteins C, S
Christmas Disease: - correct-answer-Deficiency in Factor IX
,3|Page
Amorphous urates is found in: - correct-answer-Acidic pH urine
Amorphous phosphate crystals are found in: - correct-answer-Amorphous
phosphate, triple phosphate (ammonium magnesium phosphate), calcium
phosphate, and ammonium urate crystals are frequently found in alkaline urine
specimens
Which method is the gold standard for ANA detection: - correct-answer-Slide-
based immunofluorescent assay (IFA) or colorzyme
NASBA - correct-answer-Nucleic acid sequence based amplification (NASBA) is a
method in molecular biology which is used to amplify RNA sequences
Used to monitor viral load in HIV paitents
Which condition will show an increased PT with a normal aPTT? - correct-answer-
Factor VII deficiency
, 4|Page
A biomarker with high sensitivity: - correct-answer-accurately identifies the
presence of disease and hos few false-negatives
A biomarker with a high specificity: - correct-answer-accurately detects the
absence of disease and has few false-positives
Leukemoid Reaction Lab Results: - correct-answer-A high white blood cell count,
usually 50-100 x109/L with a left shift is a common finding in leukemoid reactions.
In addition, a key feature of a leukemoid reaction is a high LAP score
Low LAP score: - correct-answer-Paroxysmal Nocturnal Hemoglobinuria, CML
Tay-Sachs Disease: - correct-answer-A rare inherited disorder characterized by the
near-total deficiency of the enzyme N-acetylbetahexosaminidase A.
Term that means varying degree of leukocytosis with a shift to the left and
occasional nucleated red cell in the peripheral blood: - correct-answer-
Leukoerythroblastosis
