Lecture 7-GIP and GLP-1 Exam Questions and Answers Solved Correctly Rated A+

Lecture 7-GIP and GLP-1 Exam Questions and Answers Solved Correctly Rated A+

glucose-dependent insulinotropic peptide - AnswersGIP

Oral - Answers___ glucose gives greater insulin response than IV, IP, or SC

reduced - AnswersThere is a ____ incretin effect in people with Type 2 Diabetes

Food - Answers___ stimulates incretin secretion

7-36 - AnswersThe bioactive form of GLP-1 is (___) amide

1-42 - AnswersThe bioactive form of GIP is (___)

GLP-1

GIP - AnswersDPP-4 converts ___ and ___ to their inactive metabolites

N - AnswersDPP-4 cleaves off at the ___-terminus of each (GLP-1 and GIP), inactivating them

2 - AnswersDPP-4 cleaves off the first ___ amino acids of GIP and GLP-1, deactivating them

portal

systemic - AnswersDPP-4 is widely expressed, including on the surface of ___ endothelial cells so a large
proportion o GLP-1 and GIP never reach the ___ circulation

9-36

3-42 - AnswersThe inactive form of GLP-1 is (___) amide and the inactive form of GIP is (____)

GIP - AnswersK cells release ___

duodenum - AnswersK cells are primarily found in the ___

GLP-1 - AnswersL cells release ___

ileum and colon - AnswersL cells are found distally, in the ___ and ___

peripheral - AnswersGIP actions occur in ___ tissues

GIP and GLP-1 - AnswersThe incretin effect is lost after ___ and ___ are proteolyzed by DPP-4

nutrients - AnswersGIP secretion is stimulated by ___

depolarization

GIP - AnswersWhen K cells sense nutrients, they promote ___ of the membrane, causing an increase of
Ca2+ into the cell to release ___

, directly - AnswersThe Uptake pathway ___ takes up glucose and ions

2 and 5 - AnswersThe Uptake pathway of glucose via the electroneutral pathway into K cells occurs
through the GLUT___ and GLUT___ transporters

1 and 3 - AnswersThe Uptake pathway of glucose via the electrogenic pathway into K cells occurs
through SGLT___ and SGLT___

- Answers___ of glucose into the K cell occurs via the transporters GLUT2 and GLUT 5 (electroneutral
pathway) or SGLT1 and SGLT3 (electrogenic pathway)

increase - AnswersOnce glucose has entered into the K cell, this will ___ the ATP/ADP ratio, by
generating more energy

Katp channel - AnswersAn increase in ATP in the K cell inhibits the ___ channel, depolarizing the cell

does not - AnswersThe Surface Detection pathway ___ transport things into the cell directly

SGLT3 - AnswersThe Surface Detection pathway of glucose in K cells, via electrogenic path, involves the
___ transporter

Tas - AnswersThe Surface Detection pathway of glucose in K cells, via electroneutral path, involves the
___ receptor

amino acid

glucose - AnswersThe SGLT3 transporter has ___ changes, stopping it from transporting glucose into the
cell, and instead acts as a ___ sensor

SGLT3 transporter

Cl - AnswersGlucose binding to the ___ will help depolarize the cell and ___ is transported out of the cell

glucose and sucrose - AnswersTas receptors are taste receptors that bind to things like ___ and ___

cAMP - AnswersThe Tas receptor is a G-protein coupled receptor that activates adenylyl cyclase to make
___

Vg Ca - AnswersThe net effect of the uptake and surface detection pathways and their mechanisms is to
depolarize the membrane helping to open Vg Na channels and primarily ___ channels

Ca

cAMP - AnswersIncreases in intracellular ___ and ___ promotes exocytosis of GIP granules

nutrients and GIP - AnswersGLP-1 secretion is stimulated by ___ and ___

GLP-1 - Answers___ release is stimulated by a 2 phase wave of stimulation