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1. what is Acne Vulgaris?: commonly called acne is the most common skin condition that
a clinician will see in primary care.
2. Systemic retinoids (isotretinoin): for severe acne it normalized the keratinizing process
and reduce sebum production. reduce sebaceous gland size and inflammation.
dosed : 0.5-1mg/kg for 15-20 weeks
mostly dermatologist prescribe these medications.
3. isotretinoin (Amnesteem)*: Used for severe nodulocystic acne vulgaris -Vitamin A
derivative
-A single course of therapy produces complete and prolonged remission
-Use restricted to patients with severe disfiguring acne
-Nosebleeds, lip or eye inflammation, and dryness or itching of the skin, nose, and mouth. Pain,
tenderness, or stiffness in muscles, bones, and joints may occur.
Less common reactions are skin rash, headache, *hair loss, and skin peeling from the palms and
soles*, reduction in vision, cataracts, optic neuritis, sunburn, and ED.
4. isotretinoin precautions*: -Wear sunscreen
,-Avoid sun exposure
-elevate triglycerideses
-Avoid alcohol
-teratogenic (register patients in the I Pledge program to avoid pregnancy).
-Depression and possible suicide are rare
-*Vitamin A supplementation and tetracyclines should be discontinued prior to therapy*
5. what labs to monitor when taking isotretinoin*: Lipids ( can increase triglycerides; that is
why do a fasting lipid panel), glucose, CBC, liver enzymes, eye exam, and pregnancy test.
6. iPLEDGE program*: -Requirements for dispensing isotretinoin (accutane).
-ensure women prescribed do not become pregnant
A central automated system that tracks patients, prescribers, pharmacists, and wholesalers.
7. requirements for starting isotretinoin for women: - two negative pregnancy tests
- negative test before each refill monthly
-two methods of birth control
- must be on birth control a month prior to the start of the treatment.
- information from pledge on contraception
-must sign a patient information/informed consent
8. Tretinoin (Renova) 0.05%*: used for acne vulgaris and rosacea.
,NOT RECOMMENDED FOR CHILDREN YOUNGER THAN 10 YEARS OLD.
9. Tretinoin (Retin-A) cream, gel, and liquid*: used for acne vulgaris allow the effects of
other topical agents to subside before use.
-start at a lower dose first
can start using every other evening
10. Initiating Tretinoin therapy? *: Start with Retin-A 0.025% cream 3-4 times per week at
bedtime until patient can tolerate a daily dose.
- make sure skin is completely dry before applying
- gradually increase to 0.05% cream or 0.025% gel, if not improvement increase to 0.1%.
11. sample prescription: Tretinoin topical 0.025% cream
Disp: 20 gram tube
Sig: Apply to face at night avoiding eyes and mouth
12. Adapalene (Differin)* OTC or Rx: first line for all acne variants
- less sensitive than tretinoin
-may be used during pregnancy
, 13. Adapalene (Differin) side effects: Include burning, peeling, stinging, pruritus, erythema,
and dryness.
14. benzoyl peroxide: -Effective antibacterial agent targeting Propionibacterium acnes
-remove excess sebum.
15. Topical Retinoids: tretinoin, adapalene, tazarotene
2nd line treatment
increase cell turnover to decrease microcomedo formation. this unplugs comedones and
prevents the development of new ones- take time.
not recommended for pregnant women.
16. Keratolytic used for acne: for mild acne include azelaic acid and salicylic acid 17.
Keratolytic MOA: decrease the growth of P.acnes
decrease the proliferation of keratinocytes decrease
the thickness of the stratum corneum may reduce
pigmentation of the skin.
18. oral antibiotics for acne: -Antibacterial and anti-inflammatory agents are used for
moderate-severe acne.
Doxycycline( most commonly used)
Minocycline
Tetracycline