USMLE STEP 1 Pharmacology
Questions and Answers | Latest Version
| 2025/2026 | Correct & Verified
Which drug is used to treat bradycardia by increasing heart rate through muscarinic blockade?
✔✔ Atropine
Which class of diuretics is contraindicated in sulfa allergy?
✔✔ Thiazides
Which drug irreversibly inhibits platelet aggregation by acetylating COX enzymes?
✔✔ Aspirin
Which insulin type has the fastest onset of action?
✔✔ Lispro
Which antibiotic inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit?
✔✔ Gentamicin
1
,Which anticoagulant enhances antithrombin III activity and inhibits factor Xa and IIa?
✔✔ Heparin
Which beta-blocker is selective for beta-1 receptors and used in heart failure?
✔✔ Metoprolol
Which lipid-lowering drug inhibits HMG-CoA reductase?
✔✔ Atorvastatin
Which antipsychotic is known for causing agranulocytosis?
✔✔ Clozapine
Which antifungal inhibits ergosterol synthesis by blocking lanosterol demethylase?
✔✔ Fluconazole
Which bronchodilator acts as a beta-2 agonist for acute asthma relief?
✔✔ Albuterol
2
,Which drug is a dopamine D2 receptor antagonist used for nausea and gastroparesis?
✔✔ Metoclopramide
Which antiepileptic drug blocks sodium channels and is teratogenic?
✔✔ Phenytoin
Which antidepressant inhibits reuptake of serotonin and norepinephrine?
✔✔ Venlafaxine
Which immunosuppressant inhibits calcineurin and decreases IL-2 transcription?
✔✔ Cyclosporine
Which opioid is a partial mu agonist and can precipitate withdrawal in opioid-dependent
patients?
✔✔ Buprenorphine
Which drug is used in acetaminophen overdose to replenish glutathione?
✔✔ N-acetylcysteine
3
, Which proton pump inhibitor is used to treat peptic ulcers and GERD?
✔✔ Omeprazole
Which antidiabetic drug increases insulin sensitivity by activating PPAR-gamma?
✔✔ Pioglitazone
Which antiarrhythmic drug blocks potassium channels and prolongs repolarization?
✔✔ Amiodarone
Which alpha-1 blocker is used to treat benign prostatic hyperplasia and hypertension?
✔✔ Tamsulosin
Which selective serotonin reuptake inhibitor is commonly used for depression?
✔✔ Sertraline
Which antiplatelet drug blocks ADP receptors to prevent platelet aggregation?
✔✔ Clopidogrel
4
Questions and Answers | Latest Version
| 2025/2026 | Correct & Verified
Which drug is used to treat bradycardia by increasing heart rate through muscarinic blockade?
✔✔ Atropine
Which class of diuretics is contraindicated in sulfa allergy?
✔✔ Thiazides
Which drug irreversibly inhibits platelet aggregation by acetylating COX enzymes?
✔✔ Aspirin
Which insulin type has the fastest onset of action?
✔✔ Lispro
Which antibiotic inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit?
✔✔ Gentamicin
1
,Which anticoagulant enhances antithrombin III activity and inhibits factor Xa and IIa?
✔✔ Heparin
Which beta-blocker is selective for beta-1 receptors and used in heart failure?
✔✔ Metoprolol
Which lipid-lowering drug inhibits HMG-CoA reductase?
✔✔ Atorvastatin
Which antipsychotic is known for causing agranulocytosis?
✔✔ Clozapine
Which antifungal inhibits ergosterol synthesis by blocking lanosterol demethylase?
✔✔ Fluconazole
Which bronchodilator acts as a beta-2 agonist for acute asthma relief?
✔✔ Albuterol
2
,Which drug is a dopamine D2 receptor antagonist used for nausea and gastroparesis?
✔✔ Metoclopramide
Which antiepileptic drug blocks sodium channels and is teratogenic?
✔✔ Phenytoin
Which antidepressant inhibits reuptake of serotonin and norepinephrine?
✔✔ Venlafaxine
Which immunosuppressant inhibits calcineurin and decreases IL-2 transcription?
✔✔ Cyclosporine
Which opioid is a partial mu agonist and can precipitate withdrawal in opioid-dependent
patients?
✔✔ Buprenorphine
Which drug is used in acetaminophen overdose to replenish glutathione?
✔✔ N-acetylcysteine
3
, Which proton pump inhibitor is used to treat peptic ulcers and GERD?
✔✔ Omeprazole
Which antidiabetic drug increases insulin sensitivity by activating PPAR-gamma?
✔✔ Pioglitazone
Which antiarrhythmic drug blocks potassium channels and prolongs repolarization?
✔✔ Amiodarone
Which alpha-1 blocker is used to treat benign prostatic hyperplasia and hypertension?
✔✔ Tamsulosin
Which selective serotonin reuptake inhibitor is commonly used for depression?
✔✔ Sertraline
Which antiplatelet drug blocks ADP receptors to prevent platelet aggregation?
✔✔ Clopidogrel
4
