Antimetabolites - CSO exam questions with complete solutions

Antimetabolites - CSO exam questions with complete
solutions




What are antimetabolites?

Chemo agents that interfere with DNA synthesis by acting as false metabolites. They becom
incorporated into the DNA strand or block essential enzymes.

Are antimetabolites cell cycle specific or cell cycle non specific?

They are cell cycle specific

What phase is affected by antimetabolites?

S-phase.

Azacitidine AKA

Vidaza

How is Azacitidine given?

Via SC or IV

What does Azacitidine treat?

CML or MDS.

Side effects of Azacitidine

myelosuppression, n/v/c/d, fatigue, decreased K+, and renal toxicity.

Capecitabine AKA

Xeloda

How is Capecitabine given?

Oral

What does capecitabine treat?

Cancers of colon, esophagus, pancreas, rectum and metastatic breast cancer.

, Sid effects of capecitabine

myelosuppression, n/v/d, fatigue, increased bili, and handfoot syndrome.

Cytarabine AKA

ARA-C

How is cytarabine given?

IV, SC, IT or IM

What does cytarabine treat?

AML, APL, ALL, CML and NHL.

Side effects of cytarabine

myelosuppression, n/v, mucositis, anorexia, acute pancreatitis, neuro/hepatic/pulm toxicity,
conjunctivitis and keratitis.

Fludarabine AKA

Fludara

How is fludarabine given?

IV

What does fludarabine treat?

CLL, NHL and acute leukemias.

Side effects of fludarabine

myelosuppression, n/v/d, neurotoxicity and rash.

Fluorouracil AKA

5-FU

How is fluorouracil given?

IV and topical

what does fluorouracil treat?

Cancers of breast, colon, rectum, cervix, GI, H&N, pancreas, ovaries and stomach. Unknown
primaries. hepatobiliary, neuroendocrine and thymic.

Side effects of fluorouracil