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ASCP Hematology Exam – MLT Level with Correct Questions and Answers (Grade A+)

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This document contains a complete and verified set of questions and correct answers for the ASCP Hematology Exam at the Medical Laboratory Technician (MLT) level. It covers essential hematology topics including blood cell morphology, coagulation pathways, hematologic disorders, instrumentation, and quality control. Updated for current certification standards, this resource is perfect for MLT candidates aiming for an A+ score on the hematology section of the ASCP exam.

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ASCP Hematology -MLT
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ASCP Hematology -MLT

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Uploaded on
July 14, 2025
Number of pages
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Written in
2024/2025
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Questions & answers

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ASCP Hematology Exam-MLT questions and answers
2024\2025 A+ Grade



The light-colored zone adjacent to the nucleus in a plasmacyte is the:



A. ribosome

B. chromatin

C. mitochondria

D. Golgi area
- correct answer D. Golgi area



The majority of the iron in an adult is found as a constituent of:



A. hemoglobin

B. hemosiderin

C. myoglobin

D. transferrin
- correct answer A. hemoglobin



The main function of the hexose monophosphate shunt in the erythrocyte is to:



A. reglate the level of 2,3-DPG

B. provide reduced glutathione to prevent oxidation of hemoglobin

C. prevent the reduction of heme iron

D. provide energy for membrane maintenance
- correct answer B. provide the level 2,3-DPG

,In order for hemoglobin to combine reversibly with oxygen, the iron must be:



A. complexed with haptoglobin

B. freely circulating in the cytoplasm

C. attached to transferrin

D. in the ferrous state
- correct answer D. in the ferrous state



In which of the following disease states are teardrop cells and adnormal platelets most characteristically
seen?



A. hemolytic anemia

B. multiple myeloma

C. G-6-PD deficiency

D. myeloid metaplasma
- correct answer D. myeloid metaplasia



In the normal adult, the spleen acts as a site for:



A. storage of red blood cells

B. production of red blood cells

C. synthesis of erythropoietin

D. removal of imperfect and aging cells
- correct answer D. removal of imperfect and aging cells



After removal of red blood cells from the circulation hemoglobin is broken down into:



A. iron, porphyrin, and amino acids

B. iron, protoporphyrin, and globin

C. heme, protoporphyrin, and amino acids

, D. heme, hemoseridin, and globin
- correct answer B. iron, protoporphyrin, and globin



Heinz bodies are:



A. readily identified with polychrome stains

B. rarely found in glucose-6-phosphate dehydrogenase deficient erythrocytes

C. closely associated with spherocytes

D. denatured hemoglobin inclusions that are readily removed by the spleen
- correct answer D. denatured hemoglobin inclusions that are readily removed by the spleen



Cells for the transport of O2 and CO2 are:



A. erythrocytes

B. granulocytes

C. lymphocytes

D. thrombocytes
- correct answer A. erythrocytes



Erythropoeitin acts to:



A. shorten the replication time of the granulocytes

B. stimulate RNA synthesis of erythroid cells

C. increase colony-stimulating factors produced by the B-lymphocytes

D. decrease the release of marrow reticulocytes
- correct answer B. stimulate RNA synthesis of erythroid cells



What cell shape is most commonly associated with an increase MCHC?



A. teardrop cells

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