Idaho Pharmacist Exam
Question 1. Which phase of pharmacokinetics primarily determines the
onset of a drug’s action?
A) Absorption
B) Distribution
C) Metabolism
D) Excretion
Answer: A
Explanation: Absorption is the process by which a drug enters the
bloodstream from its site of administration, directly influencing how
quickly the drug begins to exert its effect.
Question 2. Which of the following best illustrates a drug-drug
interaction leading to increased toxicity?
A) Warfarin and amiodarone
B) Penicillin and probenecid
C) CYP450 inducers and oral contraceptives
D) Antacids and tetracycline
Answer: A
Explanation: Warfarin and amiodarone interact to increase anticoagulant
effects, raising bleeding risk, exemplifying a drug-drug interaction that
can enhance toxicity.
, Idaho Pharmacist Exam
Question 3. Which statement best describes pharmacogenomics?
A) The study of how drugs are metabolized in the liver
B) The use of genetic information to tailor medication therapy
C) The assessment of drug efficacy in population studies
D) The monitoring of adverse drug reactions in clinical practice
Answer: B
Explanation: Pharmacogenomics involves analyzing genetic variations
that influence individual responses to drugs, facilitating personalized
medicine.
Question 4. Which chemical property is most characteristic of beta-
lactam antibiotics?
A) Aromatic ring structure
B) Presence of a beta-lactam ring
C) High lipophilicity
D) Acidic pKa
Answer: B
Explanation: Beta-lactam antibiotics contain a beta-lactam ring essential
for their antibacterial activity by inhibiting cell wall synthesis.
, Idaho Pharmacist Exam
Question 5. Which dosage form is best suited for rapid absorption in
emergency situations?
A) Extended-release tablets
B) Sublingual tablets
C) Transdermal patches
D) Capsules
Answer: B
Explanation: Sublingual tablets allow direct absorption through the
mucous membranes, providing rapid onset of action suitable for
emergencies.
Question 6. Which of the following is a key principle of sterile
compounding?
A) Use of alcohol-based hand sanitizers only
B) Maintaining aseptic technique to prevent contamination
C) Preparing medications in non-sterile environments for stability
D) Avoiding the use of sterile gloves during preparation
Answer: B
Explanation: Sterile compounding requires maintaining aseptic
technique to prevent microbial contamination and ensure patient safety.
, Idaho Pharmacist Exam
Question 7. Which cardiovascular condition is characterized by the
heart’s inability to pump blood effectively, often leading to fluid
retention?
A) Hypertension
B) Heart failure
C) Arrhythmia
D) Atherosclerosis
Answer: B
Explanation: Heart failure involves impaired pumping function,
resulting in decreased cardiac output and fluid buildup.
Question 8. In managing type 2 diabetes, which medication class is
primarily used to increase insulin sensitivity?
A) Sulfonylureas
B) Biguanides (metformin)
C) SGLT2 inhibitors
D) Insulin analogs
Answer: B
Explanation: Biguanides, especially metformin, improve insulin
sensitivity and decrease hepatic glucose production.
Question 1. Which phase of pharmacokinetics primarily determines the
onset of a drug’s action?
A) Absorption
B) Distribution
C) Metabolism
D) Excretion
Answer: A
Explanation: Absorption is the process by which a drug enters the
bloodstream from its site of administration, directly influencing how
quickly the drug begins to exert its effect.
Question 2. Which of the following best illustrates a drug-drug
interaction leading to increased toxicity?
A) Warfarin and amiodarone
B) Penicillin and probenecid
C) CYP450 inducers and oral contraceptives
D) Antacids and tetracycline
Answer: A
Explanation: Warfarin and amiodarone interact to increase anticoagulant
effects, raising bleeding risk, exemplifying a drug-drug interaction that
can enhance toxicity.
, Idaho Pharmacist Exam
Question 3. Which statement best describes pharmacogenomics?
A) The study of how drugs are metabolized in the liver
B) The use of genetic information to tailor medication therapy
C) The assessment of drug efficacy in population studies
D) The monitoring of adverse drug reactions in clinical practice
Answer: B
Explanation: Pharmacogenomics involves analyzing genetic variations
that influence individual responses to drugs, facilitating personalized
medicine.
Question 4. Which chemical property is most characteristic of beta-
lactam antibiotics?
A) Aromatic ring structure
B) Presence of a beta-lactam ring
C) High lipophilicity
D) Acidic pKa
Answer: B
Explanation: Beta-lactam antibiotics contain a beta-lactam ring essential
for their antibacterial activity by inhibiting cell wall synthesis.
, Idaho Pharmacist Exam
Question 5. Which dosage form is best suited for rapid absorption in
emergency situations?
A) Extended-release tablets
B) Sublingual tablets
C) Transdermal patches
D) Capsules
Answer: B
Explanation: Sublingual tablets allow direct absorption through the
mucous membranes, providing rapid onset of action suitable for
emergencies.
Question 6. Which of the following is a key principle of sterile
compounding?
A) Use of alcohol-based hand sanitizers only
B) Maintaining aseptic technique to prevent contamination
C) Preparing medications in non-sterile environments for stability
D) Avoiding the use of sterile gloves during preparation
Answer: B
Explanation: Sterile compounding requires maintaining aseptic
technique to prevent microbial contamination and ensure patient safety.
, Idaho Pharmacist Exam
Question 7. Which cardiovascular condition is characterized by the
heart’s inability to pump blood effectively, often leading to fluid
retention?
A) Hypertension
B) Heart failure
C) Arrhythmia
D) Atherosclerosis
Answer: B
Explanation: Heart failure involves impaired pumping function,
resulting in decreased cardiac output and fluid buildup.
Question 8. In managing type 2 diabetes, which medication class is
primarily used to increase insulin sensitivity?
A) Sulfonylureas
B) Biguanides (metformin)
C) SGLT2 inhibitors
D) Insulin analogs
Answer: B
Explanation: Biguanides, especially metformin, improve insulin
sensitivity and decrease hepatic glucose production.
