Advanced Pharmacotherapeutics Exam 1 || with Certified Answers.
WHO prescribing process correct answers Define the diagnosis
Specify the treatment objective
Choose the correct therapy
Start the therapy
Educate the patient on the diagnosis and therapy
Monitor the effects
The FDA correct answers protect public health to ensure safety and efficacy, as well as human
and veterinary drugs, biological products, food and medical devices.
Pharmacodynamics correct answers What the drug does to the body
Pharmacokinetics correct answers What the body does to the drug
Four examples of pharmacokinetics correct answers Absorption
Distribution
Metabolism
Elimination
Absorption correct answers Also called bioavailability-- The transfer of a drug from the site of
administration to the bloodstream. Mostly occurs through passive diffusion
-Effected by route, properties, surface area and contact time.
Efficacy correct answers The desired effect of the drug has been reached.
Potency correct answers Amount of drug desired to reach efficacy and cause an effect.
, Volume of Distribution correct answers The amount of drug in the body, divided by the plasma
protein in the body.
Small Volume of Distribution correct answers Example: If the drug is large moleculed, ionized
and protein bound-- Smaller distribution rate because it is protein bound, large and cannot pass
through passive diffusion
Lipophillic correct answers Fat-loving drugs. Can cross barriers easily, have a high volume of
distribution, small in size and unionized.
Hydrophillic correct answers Water loving drugs- IONIZED. Do not cross the membranes very
easily, has a low vol of distribution.
Metabolism correct answers the breakdown and the inactivation of a drug.
conjugation correct answers liver making a substance water soluable in order for body to
eliminate it.
first pass metabolism correct answers The drug is weakened because of the breakdown in the GI
system which passes to the hepatic portal vein, and the liver eliminated most of the drug. Greatly
reduced bioavailability of the drug.
CYP-450 correct answers Major enzymes that are involved in drug metabolism. Drugs can
inhibit or induce CYP system.
CYP Inhibitors correct answers Inhibit the metabolism of the enzyme that will metabolize the
drug.
Ex: Grapefruit and peloma juices.
Larger amount of the drug will be sent into the systemic circulation (statins)
WHO prescribing process correct answers Define the diagnosis
Specify the treatment objective
Choose the correct therapy
Start the therapy
Educate the patient on the diagnosis and therapy
Monitor the effects
The FDA correct answers protect public health to ensure safety and efficacy, as well as human
and veterinary drugs, biological products, food and medical devices.
Pharmacodynamics correct answers What the drug does to the body
Pharmacokinetics correct answers What the body does to the drug
Four examples of pharmacokinetics correct answers Absorption
Distribution
Metabolism
Elimination
Absorption correct answers Also called bioavailability-- The transfer of a drug from the site of
administration to the bloodstream. Mostly occurs through passive diffusion
-Effected by route, properties, surface area and contact time.
Efficacy correct answers The desired effect of the drug has been reached.
Potency correct answers Amount of drug desired to reach efficacy and cause an effect.
, Volume of Distribution correct answers The amount of drug in the body, divided by the plasma
protein in the body.
Small Volume of Distribution correct answers Example: If the drug is large moleculed, ionized
and protein bound-- Smaller distribution rate because it is protein bound, large and cannot pass
through passive diffusion
Lipophillic correct answers Fat-loving drugs. Can cross barriers easily, have a high volume of
distribution, small in size and unionized.
Hydrophillic correct answers Water loving drugs- IONIZED. Do not cross the membranes very
easily, has a low vol of distribution.
Metabolism correct answers the breakdown and the inactivation of a drug.
conjugation correct answers liver making a substance water soluable in order for body to
eliminate it.
first pass metabolism correct answers The drug is weakened because of the breakdown in the GI
system which passes to the hepatic portal vein, and the liver eliminated most of the drug. Greatly
reduced bioavailability of the drug.
CYP-450 correct answers Major enzymes that are involved in drug metabolism. Drugs can
inhibit or induce CYP system.
CYP Inhibitors correct answers Inhibit the metabolism of the enzyme that will metabolize the
drug.
Ex: Grapefruit and peloma juices.
Larger amount of the drug will be sent into the systemic circulation (statins)
