Test Bank - Cellular and Molecular Immunology,
10th Edition (Abbas, 2022), Chapter 1-21 | All
Chapters
1. Which of the following cells are primarily responsible for antigen
presentation to naïve T cells?
A. Neutrophils
B. Eosinophils
C. Dendritic cells
D. Basophils
Dendritic cells are the most effective antigen-presenting cells
(APCs) for initiating T cell responses due to their high expression of
MHC and co-stimulatory molecules.
2. Which type of immunity is mediated by antibodies?
A. Cell-mediated immunity
B. Humoral immunity
C. Innate immunity
D. Passive immunity
Humoral immunity involves B cells and antibodies that neutralize
pathogens in extracellular spaces.
,3. What is the role of the thymus in the immune system?
A. Activation of B cells
B. Maturation of T cells
C. Activation of macrophages
D. Production of antibodies
The thymus is the primary lymphoid organ where T cells mature
and undergo selection.
4. Which cytokine is critical for the differentiation of Th1 cells?
A. IL-4
B. IL-12
C. IL-10
D. IL-6
IL-12 promotes Th1 differentiation and enhances the cell-mediated
immune response.
5. What molecule on T cells recognizes MHC-peptide complexes?
A. CD28
B. CD40L
C. TCR (T-cell receptor)
D. CTLA-4
The T-cell receptor (TCR) specifically binds to antigenic peptides
presented by MHC molecules.
6. Which complement component is central to all three pathways of
activation?
A. C1q
, B. C3
C. C5
D. C9
C3 is a key complement protein that is activated in all complement
pathways, leading to opsonization, inflammation, and lysis.
7. What type of immunoglobulin is most efficient at crossing the placenta?
A. IgA
B. IgM
C. IgG
D. IgE
IgG is the only antibody isotype that crosses the placenta to
provide passive immunity to the fetus.
8. Which process allows a B cell to change the class of antibody it produces
without altering antigen specificity?
A. Somatic recombination
B. Class switch recombination
C. V(D)J recombination
D. Clonal deletion
Class switch recombination changes the constant region of the
antibody while preserving the variable region.
9. What is the function of regulatory T cells (Tregs)?
A. Destroy infected cells
B. Suppress immune responses
C. Activate B cells
, D. Secrete antibodies
Tregs maintain immune homeostasis and prevent autoimmune
responses by suppressing overactive immune cells.
10.Which Toll-like receptor recognizes bacterial lipopolysaccharide (LPS)?
A. TLR4
B. TLR3
C. TLR9
D. TLR7
TLR4 is the receptor for LPS, a component of Gram-negative
bacterial walls, initiating innate immune responses.
11.Which cells are the main producers of type I interferons during viral
infections?
A. B cells
B. Plasmacytoid dendritic cells
C. NK cells
D. Neutrophils
Plasmacytoid dendritic cells produce large amounts of type I
interferons (IFN-α and IFN-β) in response to viral infection.
12.Which MHC class is expressed on all nucleated cells?
A. MHC Class II
B. MHC Class I
C. Both Class I and II
10th Edition (Abbas, 2022), Chapter 1-21 | All
Chapters
1. Which of the following cells are primarily responsible for antigen
presentation to naïve T cells?
A. Neutrophils
B. Eosinophils
C. Dendritic cells
D. Basophils
Dendritic cells are the most effective antigen-presenting cells
(APCs) for initiating T cell responses due to their high expression of
MHC and co-stimulatory molecules.
2. Which type of immunity is mediated by antibodies?
A. Cell-mediated immunity
B. Humoral immunity
C. Innate immunity
D. Passive immunity
Humoral immunity involves B cells and antibodies that neutralize
pathogens in extracellular spaces.
,3. What is the role of the thymus in the immune system?
A. Activation of B cells
B. Maturation of T cells
C. Activation of macrophages
D. Production of antibodies
The thymus is the primary lymphoid organ where T cells mature
and undergo selection.
4. Which cytokine is critical for the differentiation of Th1 cells?
A. IL-4
B. IL-12
C. IL-10
D. IL-6
IL-12 promotes Th1 differentiation and enhances the cell-mediated
immune response.
5. What molecule on T cells recognizes MHC-peptide complexes?
A. CD28
B. CD40L
C. TCR (T-cell receptor)
D. CTLA-4
The T-cell receptor (TCR) specifically binds to antigenic peptides
presented by MHC molecules.
6. Which complement component is central to all three pathways of
activation?
A. C1q
, B. C3
C. C5
D. C9
C3 is a key complement protein that is activated in all complement
pathways, leading to opsonization, inflammation, and lysis.
7. What type of immunoglobulin is most efficient at crossing the placenta?
A. IgA
B. IgM
C. IgG
D. IgE
IgG is the only antibody isotype that crosses the placenta to
provide passive immunity to the fetus.
8. Which process allows a B cell to change the class of antibody it produces
without altering antigen specificity?
A. Somatic recombination
B. Class switch recombination
C. V(D)J recombination
D. Clonal deletion
Class switch recombination changes the constant region of the
antibody while preserving the variable region.
9. What is the function of regulatory T cells (Tregs)?
A. Destroy infected cells
B. Suppress immune responses
C. Activate B cells
, D. Secrete antibodies
Tregs maintain immune homeostasis and prevent autoimmune
responses by suppressing overactive immune cells.
10.Which Toll-like receptor recognizes bacterial lipopolysaccharide (LPS)?
A. TLR4
B. TLR3
C. TLR9
D. TLR7
TLR4 is the receptor for LPS, a component of Gram-negative
bacterial walls, initiating innate immune responses.
11.Which cells are the main producers of type I interferons during viral
infections?
A. B cells
B. Plasmacytoid dendritic cells
C. NK cells
D. Neutrophils
Plasmacytoid dendritic cells produce large amounts of type I
interferons (IFN-α and IFN-β) in response to viral infection.
12.Which MHC class is expressed on all nucleated cells?
A. MHC Class II
B. MHC Class I
C. Both Class I and II
