MSN 571 EXAM STUDY GUIDE
Prescriptive authority - Answers - legal authority granted to advanced practice nurses
to prescribe medication; DETERMINED BY STATE LAW
Rational Drug Selection - Answers - based on individual patient and addresses
disease specific information: ONLY A GUIDELINE
Drug Selection - Answers - includes analysis of cost, guidelines, avaibalbility,
interactions, side effects, allergies, hepatic and renal function, need for monitoring,
special precautions i.e elderly
medication education basic components - Answers - medication name
purpose
dosing regimen
administration
adverse effects
any storage needs
associated labs testing
food & drug interactions
duration of therapy
medication adherence - Answers - barriers to adherence=
forgetfulness
lack of planning
cost
dissatisfaction
altered dosing
Phamacokinetics - Answers - study of drug movement throughout body
principles of pharmacokinetics - Answers - absorption
distribution
metabolism
excretion
Passage of drugs across membranes - Answers - - channels and pores
- transport systems (P-glycoprotein)
- direct penetration of the membrane
Absorption of drugs - Answers - Transfer of drugs from site of administration across
cell membrane into the blood stream
factors that affect absorption of drugs - Answers - rate of dissolution- how easy
dissolves
, surface area- >surface area moves faster
blood flow- >blood flow moves faster
lipid solubility - lipid easily cross membrane
ph partitioning -
Distribution of drugs - Answers - movement of drugs from systemic circulation to site of
drug action
factors that determine drug flow - Answers - blood flow to tissues
ability to exit vascular system
ability to enter cell
Drug ability to exit vascular system - Answers - capillary bed- typical
blood brain barreier
placenta drug transfer
protein binding - albumin
drug ability to enter cell - Answers - binds with receptors on external surface of cell
membrane
drug metabolism - Answers - the enzymatic biotransformation of a drug structure
most occur in liver by P450 system
first pass effect - Answers - rapid hepatic inactivation of drug on its first pass through
liver
drug excretion - Answers - elimination of a drug from the body
Drug Excretion Routes - Answers - renal
breast milk
bile
lungs
sweat
saliva
therapeutic drug range - Answers - range of drug between minimum effective dose and
toxic dose. larger index - safer dose smaller index- harmful dose
drug half life - Answers - the time required for the amount of drug in the body to
decrease by 50%
Phamacodynamics - Answers - biochemical and physiological effects of drugs on body
dose-response relationship - Answers - the relationship between the size of an
administered dose and the intensity it produces
Prescriptive authority - Answers - legal authority granted to advanced practice nurses
to prescribe medication; DETERMINED BY STATE LAW
Rational Drug Selection - Answers - based on individual patient and addresses
disease specific information: ONLY A GUIDELINE
Drug Selection - Answers - includes analysis of cost, guidelines, avaibalbility,
interactions, side effects, allergies, hepatic and renal function, need for monitoring,
special precautions i.e elderly
medication education basic components - Answers - medication name
purpose
dosing regimen
administration
adverse effects
any storage needs
associated labs testing
food & drug interactions
duration of therapy
medication adherence - Answers - barriers to adherence=
forgetfulness
lack of planning
cost
dissatisfaction
altered dosing
Phamacokinetics - Answers - study of drug movement throughout body
principles of pharmacokinetics - Answers - absorption
distribution
metabolism
excretion
Passage of drugs across membranes - Answers - - channels and pores
- transport systems (P-glycoprotein)
- direct penetration of the membrane
Absorption of drugs - Answers - Transfer of drugs from site of administration across
cell membrane into the blood stream
factors that affect absorption of drugs - Answers - rate of dissolution- how easy
dissolves
, surface area- >surface area moves faster
blood flow- >blood flow moves faster
lipid solubility - lipid easily cross membrane
ph partitioning -
Distribution of drugs - Answers - movement of drugs from systemic circulation to site of
drug action
factors that determine drug flow - Answers - blood flow to tissues
ability to exit vascular system
ability to enter cell
Drug ability to exit vascular system - Answers - capillary bed- typical
blood brain barreier
placenta drug transfer
protein binding - albumin
drug ability to enter cell - Answers - binds with receptors on external surface of cell
membrane
drug metabolism - Answers - the enzymatic biotransformation of a drug structure
most occur in liver by P450 system
first pass effect - Answers - rapid hepatic inactivation of drug on its first pass through
liver
drug excretion - Answers - elimination of a drug from the body
Drug Excretion Routes - Answers - renal
breast milk
bile
lungs
sweat
saliva
therapeutic drug range - Answers - range of drug between minimum effective dose and
toxic dose. larger index - safer dose smaller index- harmful dose
drug half life - Answers - the time required for the amount of drug in the body to
decrease by 50%
Phamacodynamics - Answers - biochemical and physiological effects of drugs on body
dose-response relationship - Answers - the relationship between the size of an
administered dose and the intensity it produces
