Conceptual Actual Exam Questions With
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1. What is insulin resistance? - ANSWER The body does not respond
properly to the insulin it makes. It is the driving factor that leads to type 2
diabetes
2. Does everyone with insulin resistance progress to T2DM? - ANSWER
Not everyone with IR will get Type 2 diabetes.
Only 25-20% of obese subjects develop Type 2 diabetes.
3. Does everyone with obesity have insulin resistance? - ANSWER No, only
2/3 of obese people have insulin resistance
4. Is everyone with IR obese? - ANSWER No. About 20% of lean people
may have insulin resistance
5. Can we predict who will get Type 2? - ANSWER Yes. If the person has a
beta cell failure
6. What is the positive feedback loop - ANSWER It is when Insulin reduces
glucose level thanks to beta-cell
,7. What is a beta cell? - ANSWER A beta cell is a cell type in the pancreas
8. What happens if you overwork the pancreas - ANSWER it can cause
beta-cell exhaustion (insulin deficiency) and without insulin, resistance is
caused.
9. Does insulin resistance cause T2DM? - ANSWER Yes. The body does not
respond to insulin being made and excess glucose is allowed into the cells.
10.What is considered the key to T2DM? - ANSWER pancreatic
exhaustion/ beta-cell failure
11.What is gestational diabetes? - ANSWER Diabetes developed during
pregnancy
12.How is gestational diabetes a warning that the.mother will develop Type 2
eventually? - ANSWER It shows how the beta cells cannot handle 6-9
months of insulin resistance. If you cannot handle 9 months of insulin
resistance, you cannot handle a lifetime of it
13.What percentage of women who had gestational diabetes progress to Type
2? - ANSWER About 50%
,14.How does genetics play a role in getting Type 2? - ANSWER If 2 parents
have Type 2, you have a 90% chance of also developing Type 2 diabetes
15.What is impaired glucose tolerance? - ANSWER blood glucose is raised
beyond normal levels. It is another predictor of type 2
16.Is Beta cell exhaustion reversable? - ANSWER No
17.What is the difference between Type 1 and Type 2? - ANSWER Type 1:
Beta cells cant make insulin
18.Type 2: You make insulin but your cells are resistant to it
19.What can help "treat"/ prevent beta cell exhaustion? - ANSWER Early
prevention is better.
20.Giving metformin early on then it improves beta-cell function.
21.Starting weight loss early.
22.Exercise.
23.What causes the positive feedback loop? - ANSWER Running low on
insulin
24.What does having cancer contain? - ANSWER Cancers have been found
to contain dozens or hundreds of mutations in their DNA
25.What is Carcinogenesis? - ANSWER The process of developing cancer
from a normal cell
, 26.How long does it take to develop aggressive cancer? - ANSWER
Decades
27.What is mutagenesis? - ANSWER Mutagenisis= genetic mutations (aka
"initiation")
28.What is mitogensis? - ANSWER Mitogensis= process of cell division (aks
"promotion" that increases the chance of cells becoming mutated)
29.How can we prevent cancer? - ANSWER We want to slow down the
genetic damage and/or slow down cell division
30.What is the multi-hit model? - ANSWER It is when cancer exhibits many
mutations in genes related to controlling proliferation (the rapid
reproduction of a cell)
31.How does one cell accumulate many mutations? - ANSWER A cell does
this by growth advantage and clonal expansion of cells with initial
mutations. The daughter cells then become targets of a new mutation.
32.Why has their been a reduction of cancer in history? - ANSWER
because of dietary factors and government regulations