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HESI Pharmacology Practice Exam 2025–2026 nursing pharmacology Accurate Real Exam 70 Questions and Verified Correct Answers JUST RELEASED

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This document provides 70 real exam-style questions with verified correct answers for the HESI Pharmacology Practice Exam, updated for the 2025–2026 academic year. It covers critical pharmacology topics including drug classifications, mechanisms of action, side effects, safe medication administration, dosage calculations, and nursing responsibilities. A valuable resource for nursing students preparing for the HESI Exit Exam or focused pharmacology assessments.

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Uploaded on
June 24, 2025
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Written in
2024/2025
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HESI Pharmacology Practice Exam 2025–2026
Accurate Real Exam 70 Questions and Verified
Correct Answers JUST RELEASED
Which nursing diagnosis is important to include in the plan of care for a client recieving
the angiotensin II receptor antagonist irbesartan (avapro)?
A. Fluid volume deficit
B.Risk for infection
C. Risk for injury
D. Impaired sleep patterns - answer>>>C. Avapro is an antihypertensive agent, which acts
by blocking vasoconstrictor effects at various receptor sites. This can cause hypotension
and dizziness, placing the client at high risk for injury

Which medications should the nurse caution the client about taking while receiving an
opioid analgesic?
A. Antacids.
B. Benzodiasepines
C. Antihypertensives
D. Oral antidiabetics - answer>>>B. respiratory depression increases with the concurrent
use of opioid analgesics and other cns depressant agents, such as alcohol, barbiturates,
and benzodiasepines

A postoperative client has been recieving a continuous IV infusion of meperidine
(demerol) 35mg/hr for four days. The client has a PRN prescription for Demorol 100mg
PO Q3H. The nurse notes that the client has become increasingly restless, irritable and
confused, stating that there are bugs all over the walls. What action should the nurse take
FIRST?
A. Administer a PRN dose of the PO meperidine (demorol)
B. Administer naloxone (narcan) IV per PRN protocol
C. Decrease the IV infusion rate of the demerol per protocol
D. notify the healthcare provider of the clients confusion and hallucinations - answer>>>C.
The client is exhibiting symptoms of demerol toxicity, which is consistent with the large

,dose of demerol recieved over four days. C. is the most effective action to immediately
decrease the amount of serum demerol.

The client with a dysrhythmia is to receive procainamide (pronestyl) in 4 divided doses
over the next 24 hours. What dosing schedule is best for the nurse to implement?
A. q6h
B. QID
C. AC and bedtime
D. PC and bedtime - answer>>>A. q6h

After abdominal surgery, a male client is prescribed low molecular weight heparin. during
administration of the medication, the client asks the nurse why he is receiving this
medication. Which is the best response for the nurse to provide.
A. This medication is a blood thinner given to prevent blood clot formation
B. this medication enhances antibiotics to prevent infection
C. This medication dissolves any glots that develop int he legs
D. This abdominal injection assists in the healing of the abdominal wound - answer>>>A

Following heparin treatment for a PE, a client is being discharged with a prescription for
warfarin. In conducting discharge teaching, the nurse advises the client to have which
diagnostic test monitored regularly?
A. Perfusion scan
B. Prothrombin time (PT/INR)
C. Activated Partial thromboplastin (APTT)
D. Serum Coumadin Level (SCL) - answer>>>B. When used for a client with PE, the
therapeutic goal for wafarin therapy is a PT 1/5 to 2/5 times greater than the control or
an INR of 2-3. A perfusion might be preformed to monitor lung function but not monthly.
APTT is monitored for Heparin.

A client who has been taking levodopa PO TID to control the symptoms of Parkinsons
disease has a new prescription for sustained release levodopa/carbidopa (sinemet 25/100
PO BID. The client took his levodopa at 0800. Which instruction should the nurse include
in the teaching plan for this client?

, A. take the first dose of sinemet today, as soon as your prescription is filld
B. Since you already took your levodopa, wait until tomorrow to take the sinemet
C. Take both drugs for the 1st week, then switch to taking only the sinemet.
D. You can begin taking the sinemet this evening, but do not take anymore levodopa -
answer>>>D

While taking a nursing history, the client states, "I am allergice to penicillin." what related
allergy to another type of anti-infective agent should the nurse ask the client about when
taking nursing history.
A. aminoglycosides
B. Cephalosporins
C. Sulfonamides
D. Tetracyclines - answer>>>B. Cross allergies exist between penicillins and
cephalosporins

A client asks the nurse if glipizide (Glucotrol) is an oral insulin. Which response should the
nurse provide?
A. Yes it is an oral insulin and has the same actions and properties as intermediate insulin
B. Yes, it is an oral insulin and is distributed, metabolized, and excreted in the same
manner as insulin
C. No it is not an oral insulin and can be used only when some beta cell function is present
D. No, it is not an oral insulin, but it is effective for those who are resistant to injectable
insulins - answer>>>C

An adult client has prescriptions for morphine sulfate 2.5 mg IV q6h and ketorlac (toradol)
30mg IV q6h. which action should the nurse implement?
A. administer both medications according to the prescription
B. Hold the ketorolac to prevent an antagonist effect
C. Hold the morphine to prevent an additive drug interaction
D. Contact the healthcare provider to clarify the prescription - answer>>>A. Morphine and
ketorolac can be administered concurrently and may produce additive analgesic effect
resulting in ability to reduce the dose of morphine, as seen in this prescription

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