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Quiz: thiazides Ans: ex. hydrochlorothiazide, chlorthalidone, indapamide.
Produce increased urine output by inhibiting water and sodium reabsorption
from kidney tubules. *first choice for hypertension*; *Life threatening side
effects* (aplastic anemia, thrombocytopenia, agranulocytosis, SJS). Side
effects: hypo/hyper, GI disturbances, blurred vision
Quiz: loop diuretics Ans: ex. furosemide, bumetanide. Used to decrease
hypertension and/or edema. If taken with digoxin, risk of arrhythmias. Side
effects: hypo (kalemia, calcemia, natremia, magnesemia)
Quiz: potassium sparing diuretics Ans: ex. spironolactone, eplerenone.
Used to treat hypertension, edema, hypokalemia, and hyperaldosteronism.
*Life threatening side effects* (leukopenia, SJS, thrombocytopenia,
agranulocytosis, renal/hepatic failure). If given with ACE inhibitor,
*HYPERKALEMIA*. Side effects: hyperkalemia, confusion, muscle cramps,
anemia, increased blood glucose, ataxia.
Quiz: beta blockers Ans: ex. metoprolol, atenolol, carvedilol, propranolol.
Decrease workload of the heart and therefore oxygen demands. used as
antihypertensive drugs, in combo with a diuretic, as antianginals, and
antidysrhythmic; do not stop abruptly (taper over 1-2 weeks); drug
interactions- do NOT administer to patients with asthma; side effects:
hypotension, bradycardia, arrhythmias, GI upset
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, Quiz: alpha-adrenergic blockers Ans: ex. doxazosin, prazosin. vasodilate,
decrease BP, and help maintain renal blood flow rate; *take once a day and
take first dose at bedtime*; side effects: orthostatic hypotension, tachycardia,
edema, weight gain
Quiz: alpha 1 and beta 1 adrenergic blockers Ans: ex. labetolol. side effects:
hypotension, bradycardia, parastension, depression, nasal congestion, nausea,
erectile dysfunction
Quiz: direct acting vasodilators Ans: ex. hydralazine, minoxidil. promote an
increase in blood flow to brain and kidneys; BP decreases and sodium and
water can be retained so often given with diuretic; side effects: hypotension,
reflex tachycardia, palpitations, edema, angina.
Quiz: ACE inhibitors Ans: ex. captopril, enalapril, lisinopril, benazepril,
quinapril. primarily used to treat hypertension but may also be used to treat
heart failure; contraindications- pregnancy, potassium-sparing diuretics, salt
substitutes that contain potassium; side effects: angioedema (part of body
suddenly becomes swollen), nonproductive cough, elevated potassium,
hypotension
Quiz: ARBs Ans: ex. losartan, valsartan. prevent release of aldosterone;
avoid potassium and sodium supplements; change positions slowly to avoid
orthostatic hypotension; side effects: diiness, hypotension, GI upsetzz
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