PBL 1011 Exam 2 Case Drugs Questions and Correct Answers

1




PBL 1011 Exam 2 Case Drugs Questions
and Correct Answers

Question: What is the class of HCTZ?
Answer: Antihypertensive Thiazide diuretic


Question: what is the mechanism of action of HCTZ
Answer: Thiazide diuretic
inhibits NaCl reabsoprtion in the early DCT


Question: what is the indication for HCTZ (3)
Answer: Hypertension, Treatment of edema due to heart failure, Renal
dysfunction (eg, nephrotic syndrome, acute glomerulosclerosis, chronic
renal failure)


Question: dental implications for HCTZ
Answer: orthostatic hypotension


Question: Are Thiazide diuretics K+ wasting or K+ sparing?
Answer: K+ wasting


Question: class of atenolol?
Answer: Antianginal Agent; Antihypertensive; Beta-Blocker, Beta-1
Selective


Question: mechanism of action of atenolol
Answer: selectively *blocks beta 1 receptors* (will also block beta 2
receptors in high doses); *negative inotropic, chronotropic and
dromotropic properties*; relative vasoconstriction suppresses renin
production thereby lowering blood pressure




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,2


Question: indications for atenolol
Answer: treatment of hypertension, (+ angina, prophylaxis and acute
myocardial infarction )


Question: dental implications for atenolol
Answer: Local anesthetic with vasoconstrictor can be safely used in
patients medicated with atenolol.


Question: T/F: an IV α-blocker (e.g., phenoxybenzamine) is given
before β-blockers to prevent unopposed α-adrenergic vasoconstriction
Answer: true


Question: captopril class
Answer: ACE inhibitor


Question: captopril MoA
Answer: * Competitive inhibitor of angiotensin-converting enzyme (ACE).
* results in lower levels of angiotensin II which causes an increase in
plasma renin activity and a redreduction uction in aldosterone secretion.


Question: captopril indication (3)
Answer: hypertension, heart failure, MI


Question: captopril dental implications (2)
Answer: dysguesia, orthostatic hypotension


Question: ACEi drugs cause what metabolic state in the blood?
Answer: hyperkalemia


Question: ACEi drugs should not be used if someone has ......?
Answer: renal hypertension (use clonidine instead)




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, 3


Question: Nifedipine class (hint: "-dipine")
Answer: Dihydropyridine Calcium Channel Blocker


Question: nifedipine MoA
Answer: inhibits calcium ion from entering "slow channels"
relaxing smooth muscle


Question: nifedipine indications
Answer: hypertension, angina


Question: nifedipine dental implications
Answer: Xerostomia;
Gingival Hyperplasia (Common to all CCBs)


Question: Nifedipine causes what side effect in Victor Dermody?
Answer: jittery


Question: nitroglycerin class
Answer: Nitrate, angi-angina, vasodilator


Question: nitroglycerin MoA
Answer: NG forms NO, cGMP cascade, smooth muscle relaxation -
VASODILATION on arteries+veins
reduces preload.


Question: nitroglycerin indications
Answer: Acute angina pectoris, hypertension


Question: nitroglycerin dental implications?
Answer: Xerostomia


Question: Dipyridamole (HK) class

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