CNPR COMPREHENSIVE EXAMS 2025/2026 QUESTIONS
WITH ANSWERS RATED A+
✔✔Which statement/s is/are INCORRECT about an ideal drug, or magic bullet as
Ehrlich phrased it? - ✔✔All of these statements are correct.
✔✔Which statement accurately differentiates resistance from tolerance? - ✔✔Tolerance
refers to a person's diminished response to a drug after repeated use, while resistance
applies to microorganisms' or cancel cells' abilities to withstand drug effects.
✔✔Between 3% and 7% of hospital admissions in the United States are estimated to be
for treatment of adverse drug reactions. - ✔✔True
✔✔Which statement is true about the universal scale for quantifying the severity of an
adverse drug reaction? - ✔✔None of these statements are true because there is no
such scale.
✔✔Why is noncompliance a serious public health concern? - ✔✔It increases the cost of
medical care.
✔✔Which of the following is NOT eligible for patent protection under U.S. regulations? -
✔✔Companies can be granted patents for all of these things.
✔✔Drugs' trade names are often unrelated to their intended use. - ✔✔False
✔✔Like foods and household products, generic drugs are usually lower quality than the
brand name drugs for which they are marketed as equivalents. - ✔✔False
✔✔Legally, bioequivalence of different versions of a drug can vary by up to ________. -
✔✔20%
✔✔Which of the following statements about biologics is INCORRECT? - ✔✔They do not
cause immune responses.
✔✔"Large molecule" products are developed and manufactured by a chemical process.
- ✔✔False
✔✔What are drugs that attract or bind to cell receptors in order to mimic or enhance
activities by endogenous chemical messengers? - ✔✔agonists
✔✔Which term denotes how an API works in the body? - ✔✔mechanism of action
,✔✔What cements the active and inert components together to maintain cohesive
portions? - ✔✔binders
✔✔What does the medical abbreviation BID denote? - ✔✔twice a day
✔✔What is the medical abbreviation for as needed? - ✔✔PRN
✔✔Which components might cause patients' different reactions to brand name and
generic drugs? - ✔✔differences in inactive ingredients
✔✔All cells have a nucleus. - ✔✔False
✔✔Which of the following does NOT affect drug response? - ✔✔All of these factors
influence drug response.
✔✔Drug reactions are predictable because they do not occur after a person has been
previously exposed to the drug one or more times without any allergic reactions. -
✔✔False
✔✔What is the typical relationship between a drug's site of administration and site of
action? - ✔✔They are usually somewhat removed from each other.
✔✔What is CMAX? - ✔✔the peak plasma concentration on a measuring curve
✔✔Which of the following is NOT a main concept in clinical pharmacology? -
✔✔Pharmacoprocesses
✔✔Which of the following is NOT a route of drug administration? - ✔✔transfugal
✔✔How are intradermal drugs delivered? - ✔✔by injection under the skin
✔✔What is an example of intravenous drug delivery? - ✔✔an injection of anesthetic
directly into the bloodstream
✔✔What are the major organs of the gastrointestinal system? - ✔✔the mouth,
esophagus, stomach, liver, pancreas, gallbladder, small and large intestines
✔✔Who is normally responsible for selling to distributors? - ✔✔NAMs
✔✔How often do secondary drug wholesale distributors buy their drugs directly from
manufactures? - ✔✔never
, ✔✔By FDA law, large chain pharmacies are not allowed to buy directly from drug
manufactures. - ✔✔False
✔✔Only 3 companies account for nearly 90% of all drug wholesale sales. - ✔✔True
✔✔What type of sale bypasses the need for intermediary distributors? -
✔✔manufacturer-direct sales
✔✔What is a group purchasing organization (GPO)? - ✔✔an entity consisting of two or
more hospitals or other health care entities that negotiates contracts on behalf of its
members
✔✔Prescriptions dispensed by mail-order pharmacies are, on average, around
____________ than those dispensed by retail pharmacies. - ✔✔3 times larger
✔✔Which of the following is NOT a type of non-stock sale? - ✔✔All of these are
examples of non-stock sales.
✔✔What is another term for rebates? - ✔✔after-market arrangements
✔✔The PDMA is the Prescription Drug Manufacturers Association. - ✔✔False
✔✔A company that owns and operates three or fewer pharmacies is an ____________.
- ✔✔independent drug store
✔✔Which section of a drug's package insert information covers the usual dosage
range? - ✔✔indications and usage
✔✔Drug labels must include indications, usage information, and contraindications. -
✔✔True
✔✔What should be included in the description section of a drug's package insert
information? - ✔✔the drug's proprietary name and the established name
✔✔Exclusivity gives exclusive _____, is granted by the FDA, and can run concurrently
with a patent or not. - ✔✔marketing rights
✔✔What differentiates exclusivity from a patent? - ✔✔Exclusivity typically lasts longer
than patents.
✔✔What is required of an invention for it to be worthy of patent protection? - ✔✔It must
be novel, useful, and not obvious.
WITH ANSWERS RATED A+
✔✔Which statement/s is/are INCORRECT about an ideal drug, or magic bullet as
Ehrlich phrased it? - ✔✔All of these statements are correct.
✔✔Which statement accurately differentiates resistance from tolerance? - ✔✔Tolerance
refers to a person's diminished response to a drug after repeated use, while resistance
applies to microorganisms' or cancel cells' abilities to withstand drug effects.
✔✔Between 3% and 7% of hospital admissions in the United States are estimated to be
for treatment of adverse drug reactions. - ✔✔True
✔✔Which statement is true about the universal scale for quantifying the severity of an
adverse drug reaction? - ✔✔None of these statements are true because there is no
such scale.
✔✔Why is noncompliance a serious public health concern? - ✔✔It increases the cost of
medical care.
✔✔Which of the following is NOT eligible for patent protection under U.S. regulations? -
✔✔Companies can be granted patents for all of these things.
✔✔Drugs' trade names are often unrelated to their intended use. - ✔✔False
✔✔Like foods and household products, generic drugs are usually lower quality than the
brand name drugs for which they are marketed as equivalents. - ✔✔False
✔✔Legally, bioequivalence of different versions of a drug can vary by up to ________. -
✔✔20%
✔✔Which of the following statements about biologics is INCORRECT? - ✔✔They do not
cause immune responses.
✔✔"Large molecule" products are developed and manufactured by a chemical process.
- ✔✔False
✔✔What are drugs that attract or bind to cell receptors in order to mimic or enhance
activities by endogenous chemical messengers? - ✔✔agonists
✔✔Which term denotes how an API works in the body? - ✔✔mechanism of action
,✔✔What cements the active and inert components together to maintain cohesive
portions? - ✔✔binders
✔✔What does the medical abbreviation BID denote? - ✔✔twice a day
✔✔What is the medical abbreviation for as needed? - ✔✔PRN
✔✔Which components might cause patients' different reactions to brand name and
generic drugs? - ✔✔differences in inactive ingredients
✔✔All cells have a nucleus. - ✔✔False
✔✔Which of the following does NOT affect drug response? - ✔✔All of these factors
influence drug response.
✔✔Drug reactions are predictable because they do not occur after a person has been
previously exposed to the drug one or more times without any allergic reactions. -
✔✔False
✔✔What is the typical relationship between a drug's site of administration and site of
action? - ✔✔They are usually somewhat removed from each other.
✔✔What is CMAX? - ✔✔the peak plasma concentration on a measuring curve
✔✔Which of the following is NOT a main concept in clinical pharmacology? -
✔✔Pharmacoprocesses
✔✔Which of the following is NOT a route of drug administration? - ✔✔transfugal
✔✔How are intradermal drugs delivered? - ✔✔by injection under the skin
✔✔What is an example of intravenous drug delivery? - ✔✔an injection of anesthetic
directly into the bloodstream
✔✔What are the major organs of the gastrointestinal system? - ✔✔the mouth,
esophagus, stomach, liver, pancreas, gallbladder, small and large intestines
✔✔Who is normally responsible for selling to distributors? - ✔✔NAMs
✔✔How often do secondary drug wholesale distributors buy their drugs directly from
manufactures? - ✔✔never
, ✔✔By FDA law, large chain pharmacies are not allowed to buy directly from drug
manufactures. - ✔✔False
✔✔Only 3 companies account for nearly 90% of all drug wholesale sales. - ✔✔True
✔✔What type of sale bypasses the need for intermediary distributors? -
✔✔manufacturer-direct sales
✔✔What is a group purchasing organization (GPO)? - ✔✔an entity consisting of two or
more hospitals or other health care entities that negotiates contracts on behalf of its
members
✔✔Prescriptions dispensed by mail-order pharmacies are, on average, around
____________ than those dispensed by retail pharmacies. - ✔✔3 times larger
✔✔Which of the following is NOT a type of non-stock sale? - ✔✔All of these are
examples of non-stock sales.
✔✔What is another term for rebates? - ✔✔after-market arrangements
✔✔The PDMA is the Prescription Drug Manufacturers Association. - ✔✔False
✔✔A company that owns and operates three or fewer pharmacies is an ____________.
- ✔✔independent drug store
✔✔Which section of a drug's package insert information covers the usual dosage
range? - ✔✔indications and usage
✔✔Drug labels must include indications, usage information, and contraindications. -
✔✔True
✔✔What should be included in the description section of a drug's package insert
information? - ✔✔the drug's proprietary name and the established name
✔✔Exclusivity gives exclusive _____, is granted by the FDA, and can run concurrently
with a patent or not. - ✔✔marketing rights
✔✔What differentiates exclusivity from a patent? - ✔✔Exclusivity typically lasts longer
than patents.
✔✔What is required of an invention for it to be worthy of patent protection? - ✔✔It must
be novel, useful, and not obvious.
