USMLE Step 1 Rapid Review Questions
Weight loss, diarrhea, arthritis, fever, adenopathy -Correct
Answer ✔ ✔ Whipple's disease (Tropheryma whippelii)
Worst headache of my life -Correct Answer ✔ ✔ USMLE
Step 1 (or subarachnoid hemorrhage)
Anticentromere antibodies -Correct Answer ✔ ✔
Scleroderma (CREST)
Antidesmoglein (epithelial) antibodies -Correct Answer ✔
✔ Pemphigus vulgaris (blistering)
AntiGBM antibodies -Correct Answer ✔ ✔ Goodpasture's
syndome (glomerulonephritis and hemoptysis)
,Antihistone antibodies -Correct Answer ✔ ✔ Drug-
induced SLE (hydralazine, isoniazid, phenytoin, procainamide)
Anti-IgG antibodies -Correct Answer ✔ ✔ RA (systemic
inflammation, joint pannus, boutonniere deformity) - IgM anti
IgG
Antimitochondrial antibodies -Correct Answer ✔ ✔ 1*
biliary cirrhosis (female, cholestasis, portal HTN)
Antineutrophil cytoplasmic antibodies (ANCA) -Correct
Answer ✔ ✔ Vasculitis (c-ANCA = Wegener's, p-ANCA =
microscopic polyangiitis or Churg-Strauss syndrome)
Antinuclear antibodies -Correct Answer ✔ ✔ SLE (type III
hypersensitivity)
,Antiplatelet antibodies -Correct Answer ✔ ✔ Idiopathic
thrombocytopenic purpura (ITP - bleeding diathesis)
Anti-topoisomerase antibodies -Correct Answer ✔ ✔
Diffuse systemic scleroderma
Anti-transglutaminase/antigliadin/anti-endomysial antibodies
-Correct Answer ✔ ✔ Celiac (diarrhea, distention, weight
loss)
Azurophilic granular needles in leukemic blasts -Correct
Answer ✔ ✔ Auer rods (AML, esp promyelocytic type)
Bamboo spine on X-ray -Correct Answer ✔ ✔ Ankylosing
spondylitis (chronic inflammatory arthritis, HLA B27)
, Basophilic nuclear remnants in RBCs -Correct Answer ✔ ✔
Howell-Jolly bodies (due to splenectomy or nonfunctional
spleen)
Basophilic stipplling of RBCs -Correct Answer ✔ ✔ Lead
poisoning or sideroblastic anemia
Bloody tap on LP -Correct Answer ✔ ✔ Subarachnoid
hemorrhage
Boot-shaped heart on X-ray -Correct Answer ✔ ✔
Tetralogy of Fallot, RVH
Branching gram + rods with sulfur granules -Correct Answer
✔ ✔ Actinomyces israelii
Bronchogenic apical lung tumor -Correct Answer ✔ ✔
Pancoast tumor (can cause Horner's)
Weight loss, diarrhea, arthritis, fever, adenopathy -Correct
Answer ✔ ✔ Whipple's disease (Tropheryma whippelii)
Worst headache of my life -Correct Answer ✔ ✔ USMLE
Step 1 (or subarachnoid hemorrhage)
Anticentromere antibodies -Correct Answer ✔ ✔
Scleroderma (CREST)
Antidesmoglein (epithelial) antibodies -Correct Answer ✔
✔ Pemphigus vulgaris (blistering)
AntiGBM antibodies -Correct Answer ✔ ✔ Goodpasture's
syndome (glomerulonephritis and hemoptysis)
,Antihistone antibodies -Correct Answer ✔ ✔ Drug-
induced SLE (hydralazine, isoniazid, phenytoin, procainamide)
Anti-IgG antibodies -Correct Answer ✔ ✔ RA (systemic
inflammation, joint pannus, boutonniere deformity) - IgM anti
IgG
Antimitochondrial antibodies -Correct Answer ✔ ✔ 1*
biliary cirrhosis (female, cholestasis, portal HTN)
Antineutrophil cytoplasmic antibodies (ANCA) -Correct
Answer ✔ ✔ Vasculitis (c-ANCA = Wegener's, p-ANCA =
microscopic polyangiitis or Churg-Strauss syndrome)
Antinuclear antibodies -Correct Answer ✔ ✔ SLE (type III
hypersensitivity)
,Antiplatelet antibodies -Correct Answer ✔ ✔ Idiopathic
thrombocytopenic purpura (ITP - bleeding diathesis)
Anti-topoisomerase antibodies -Correct Answer ✔ ✔
Diffuse systemic scleroderma
Anti-transglutaminase/antigliadin/anti-endomysial antibodies
-Correct Answer ✔ ✔ Celiac (diarrhea, distention, weight
loss)
Azurophilic granular needles in leukemic blasts -Correct
Answer ✔ ✔ Auer rods (AML, esp promyelocytic type)
Bamboo spine on X-ray -Correct Answer ✔ ✔ Ankylosing
spondylitis (chronic inflammatory arthritis, HLA B27)
, Basophilic nuclear remnants in RBCs -Correct Answer ✔ ✔
Howell-Jolly bodies (due to splenectomy or nonfunctional
spleen)
Basophilic stipplling of RBCs -Correct Answer ✔ ✔ Lead
poisoning or sideroblastic anemia
Bloody tap on LP -Correct Answer ✔ ✔ Subarachnoid
hemorrhage
Boot-shaped heart on X-ray -Correct Answer ✔ ✔
Tetralogy of Fallot, RVH
Branching gram + rods with sulfur granules -Correct Answer
✔ ✔ Actinomyces israelii
Bronchogenic apical lung tumor -Correct Answer ✔ ✔
Pancoast tumor (can cause Horner's)
