LATEST 2025 UPDATE WITH COMPLETE QUESTIONS AND CORRECTLY
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Explain why IgM must be a pentamer to be effective. - <<answer>>IgM does not go through somatic
hypermutation, so the affinity for antibody binding is low but it is in a pentamer shape. The pentamer
shape has 10 potential contact sites which have a high affinity to the antigen when summed, "Velcro
effect." IgM is also the antibody created before somatic recombination occurs.
List the 5 main isotypes (classes; NOT to subtype level) of antibody - <<answer>>IgA, IgM, IgG, IgE, IgD
the 3 antibodies that together compose 99% of all antibody in blood/body fluids: - <<answer>>IgG, IgA,
and IgM
the biggest (molecular weight) antibody - <<answer>>IgM
the most abundant antibody in serum and body fluids - <<answer>>IgG
Antibody that exists as a pentamer - <<answer>>IgM
Antibody that can cross the placenta - <<answer>>IgG
antibody that is in the highest concentration in mucus - <<answer>>IgA