MLT-MLS UAMS Hematology exam 6
UPDATED Exam Questions and CORRECT
Answers
Hemostasis - CORRECT ANSWER - The process of keeping blood in the fluid state
unless clotting occurs due to vascular injury
Primary hemostasis - CORRECT ANSWER - A platelet plug is formed on damaged
vessels
Secondary hemostasis - CORRECT ANSWER - Fibrin formation from plasma factors
What are the two roles of the vascular system? - CORRECT ANSWER - Release of
exposed substances and vasoconstriction
What are the two exposed substances in the vascular system? - CORRECT ANSWER -
Collagen and Von Willebrand's Factor
What are 3 symptoms of vascular disorders? - CORRECT ANSWER - Bruising, petechiae,
and mucuos membrane bleeding
Give an example of an inherited vascular disorder. - CORRECT ANSWER - Hereditary
telangiectasia
What are 3 causes of acquired vascular disorders? - CORRECT ANSWER - Steroids,
estrogen, and age
Parent cell of platelets - CORRECT ANSWER - megakaryocyte
,Where are megakaryocytes produced? - CORRECT ANSWER - Bone marrow
What influences the size of and the number produced of megakaryocytes? - CORRECT
ANSWER - Thrombopoietin
Endomitosis - CORRECT ANSWER - doubling of DNA without cell division
Platelet life span - CORRECT ANSWER - 8-12 days
What fraction of platelets is in circulation? - CORRECT ANSWER - 2/3
Where is the other 1/3 of platelets stored? - CORRECT ANSWER - Spleen
Platelet Plasma Membrane - CORRECT ANSWER - Contains glycocalyx that is a
receptor for glycoproteins and phospholipids
Glycoprotein IIb/IV/V is involved with platelet... - CORRECT ANSWER - adhesion
Glycoprotein IIb/IIIa is involved with platelet... - CORRECT ANSWER - aggregation
Glycoprotein Ib/IV/V binds with - CORRECT ANSWER - vWF
Glycoprotein IIb/IIIa binds to - CORRECT ANSWER - fibrinogen
Why are phospholipids necessary? - CORRECT ANSWER - Activation of the intrinsic
system and keeping the reactions localized
Platelet cytoskeleton contains - CORRECT ANSWER - The cytoskeletal and microtubules
, Dense platelet granules contain... (3) - CORRECT ANSWER - ADP, Calcium, and
serotonin
Where do dense granules release their contents upon activation? - CORRECT ANSWER -
Directly into the plasma
Alpha granules contain... - CORRECT ANSWER - Factors I, V, and vWF
What happens when alpha granules are activated? - CORRECT ANSWER - They fuse the
SCCS and their contents are released
Platelet function - CORRECT ANSWER - Aids in healing endothelial cells through
growth factors that are produced by megakaryocytes
Adhesion - CORRECT ANSWER - A reversible characteristic in which platelets roll and
cling to non-platelet surfaces
How does platelet adhesion work? - CORRECT ANSWER - Exposed collagen reacts with
vWF that activates glycoprotein Ib on the platelet surface
What happens to the shape of a platelet during adhesion? - CORRECT ANSWER - The
platelet goes from discoid to spherical with pseudopods
What causes the platelet's shape change during adhesion - CORRECT ANSWER - ADP
from endothelial cells
Platelet aggregation - CORRECT ANSWER - Platelet to platelet interaction
Is aggregation reversible? - CORRECT ANSWER - nope
UPDATED Exam Questions and CORRECT
Answers
Hemostasis - CORRECT ANSWER - The process of keeping blood in the fluid state
unless clotting occurs due to vascular injury
Primary hemostasis - CORRECT ANSWER - A platelet plug is formed on damaged
vessels
Secondary hemostasis - CORRECT ANSWER - Fibrin formation from plasma factors
What are the two roles of the vascular system? - CORRECT ANSWER - Release of
exposed substances and vasoconstriction
What are the two exposed substances in the vascular system? - CORRECT ANSWER -
Collagen and Von Willebrand's Factor
What are 3 symptoms of vascular disorders? - CORRECT ANSWER - Bruising, petechiae,
and mucuos membrane bleeding
Give an example of an inherited vascular disorder. - CORRECT ANSWER - Hereditary
telangiectasia
What are 3 causes of acquired vascular disorders? - CORRECT ANSWER - Steroids,
estrogen, and age
Parent cell of platelets - CORRECT ANSWER - megakaryocyte
,Where are megakaryocytes produced? - CORRECT ANSWER - Bone marrow
What influences the size of and the number produced of megakaryocytes? - CORRECT
ANSWER - Thrombopoietin
Endomitosis - CORRECT ANSWER - doubling of DNA without cell division
Platelet life span - CORRECT ANSWER - 8-12 days
What fraction of platelets is in circulation? - CORRECT ANSWER - 2/3
Where is the other 1/3 of platelets stored? - CORRECT ANSWER - Spleen
Platelet Plasma Membrane - CORRECT ANSWER - Contains glycocalyx that is a
receptor for glycoproteins and phospholipids
Glycoprotein IIb/IV/V is involved with platelet... - CORRECT ANSWER - adhesion
Glycoprotein IIb/IIIa is involved with platelet... - CORRECT ANSWER - aggregation
Glycoprotein Ib/IV/V binds with - CORRECT ANSWER - vWF
Glycoprotein IIb/IIIa binds to - CORRECT ANSWER - fibrinogen
Why are phospholipids necessary? - CORRECT ANSWER - Activation of the intrinsic
system and keeping the reactions localized
Platelet cytoskeleton contains - CORRECT ANSWER - The cytoskeletal and microtubules
, Dense platelet granules contain... (3) - CORRECT ANSWER - ADP, Calcium, and
serotonin
Where do dense granules release their contents upon activation? - CORRECT ANSWER -
Directly into the plasma
Alpha granules contain... - CORRECT ANSWER - Factors I, V, and vWF
What happens when alpha granules are activated? - CORRECT ANSWER - They fuse the
SCCS and their contents are released
Platelet function - CORRECT ANSWER - Aids in healing endothelial cells through
growth factors that are produced by megakaryocytes
Adhesion - CORRECT ANSWER - A reversible characteristic in which platelets roll and
cling to non-platelet surfaces
How does platelet adhesion work? - CORRECT ANSWER - Exposed collagen reacts with
vWF that activates glycoprotein Ib on the platelet surface
What happens to the shape of a platelet during adhesion? - CORRECT ANSWER - The
platelet goes from discoid to spherical with pseudopods
What causes the platelet's shape change during adhesion - CORRECT ANSWER - ADP
from endothelial cells
Platelet aggregation - CORRECT ANSWER - Platelet to platelet interaction
Is aggregation reversible? - CORRECT ANSWER - nope
