Hematology Exam 1 UPDATED Exam
Questions and CORRECT Answers
Platelets participate in which of the following processes related to hemostasis?
A. Adhesion to exposed subendothelium, activation, aggregation in primary hemostasis
B. conversion of plasminogen to plasmin, lysis of polymerized fibrin
C. release of tissue factor pathway inhibitor, inhibition of activity of TF/FVIIa complex
D. uptake of dietary vitamin K, synthesis of coagulation factors containing dicarboxy-glutamic
acid residues
E. cleavage of circulating fibrinogen to fibrinopeptides, catalysis of fibrin formation in secondary
hemostasis - CORRECT ANSWER -A
Identify the molecule with principal activity in the intrinsic coagulation cascade of reactions.
A. ε-aminocaproic acid
B. thromboxane A2
C. activated protein C complex with factor Va
D. ibruprofen
E. tissue factor - CORRECT ANSWER -E
Which statement best characterizes the role of fibrinolytic reactions in hemostasis?
A. take place prior to platelet plug formation, to provide fibrin fragments
B. reinforce the platelet plug by creating strands of fibrin that strengthen it against dissolution by
blood flow
C. only take place in the gingival vasculature
D. are initiated at the site of vascular injury at the same time as procoagulant processes
,E. are initiated only after therapeutic intravenous administration of tissue plasminogen activator
(tPA) - CORRECT ANSWER -D
Identify the molecule with non-steroidal anti-inflammatory activity
A. acetylsalicyclic acid (ASA, aspirin)
B. acetaminophen
C. ibuprofen
D. celecoxib
E. all of the molecules listed above have non-steroidal anti-inflammatory activity - CORRECT
ANSWER -E
In thinking about the major phases of coagulation, primary hemostasis, secondary hemostasis,
and fibrinolysis: which of the following general statements is *true* in healthy individuals?
A. coagulation reactions are localized to the site of vascular injury
B. coagulation reactions are limited only the the amount of available coagulation factors
C. after being initiated, coagulation reactions can spread throughout the vasculature
D. reactions that limit coagulation begin when a thrombus reaches a specific threshold size
E. thrombi produced by the coagulation reactions remain in place after vascular healing has been
completed - CORRECT ANSWER -A
T/F: Petechiae do not blanch under pressure. - CORRECT ANSWER - True
Factor XII is a component of the _______ pathway coagulation pathway.
A. extrinsic
B. intrinsic
C. common
,D. fibrinolytic
E. none of the above - CORRECT ANSWER -B
Thrombin is typically activated at what site?
A. platelet surface
B. cytoplasm of the platelet
C. in the circulation
D. in the liver
E. on the surface of one of the fibrin strands - CORRECT ANSWER -A
Which of the following antibiotics may interfere with normal hemostasis?
A. erythromycin
B. penicillin
C. tetracycline
D. metronidazole
E. more than one of the above - CORRECT ANSWER -E
Warfarin inhibits which of the following sets of coagulation factors?
A. factors II, VIII, X, and XI
B. factors II, VII, IX, and X
C. factors II, VII, X, and XI
D. factors II, III, IX, and X
E. factors II, VII, VIII, IX, and XIIII
F. it inhibits only one coagulation factor - CORRECT ANSWER -B
, Aspirin affects platelets through the following mechanism:
A. irreversibly acetylates COX1 and COX2 to reduce production of thromboxane A2 which
inhibits platelet aggregation
B. binds platelet membrane ADP receptor P2Y12
C. binds GP IIb/IIIa
D. irreversibly acetylates COX1 and COX2 to reduce production of thromboxane A2 which
stimulates platelet aggregation
E. irreversibly acetylates COX1 only to reduce production of complement factor C3b -
CORRECT ANSWER -D
LPS from gram negative bacteria such as many of the periodontal or periapical pathogens can
contribute to the induction of disseminated intravascular coagulation (DIC). LPS does this by
which of the following mechanisms?
A. activates factor XII
B. activates factor X
C. binds to the LPS-osteoclast stimulating factor and directly activates the n-F kappa beta
pathway
D. damages endothelial cells which in turn activate basophils
E. none of the above mechanisms - CORRECT ANSWER -A
Which of the following cytokines plays a critical role in causing the differentiation of a
hematopoietic stem cell into many different types of white/red blood cell lineages?
A: IL-1/TNF-alpha
B: IL-3
C: MIP-1
D: IL-8
E: IL-10 - CORRECT ANSWER -B
Questions and CORRECT Answers
Platelets participate in which of the following processes related to hemostasis?
A. Adhesion to exposed subendothelium, activation, aggregation in primary hemostasis
B. conversion of plasminogen to plasmin, lysis of polymerized fibrin
C. release of tissue factor pathway inhibitor, inhibition of activity of TF/FVIIa complex
D. uptake of dietary vitamin K, synthesis of coagulation factors containing dicarboxy-glutamic
acid residues
E. cleavage of circulating fibrinogen to fibrinopeptides, catalysis of fibrin formation in secondary
hemostasis - CORRECT ANSWER -A
Identify the molecule with principal activity in the intrinsic coagulation cascade of reactions.
A. ε-aminocaproic acid
B. thromboxane A2
C. activated protein C complex with factor Va
D. ibruprofen
E. tissue factor - CORRECT ANSWER -E
Which statement best characterizes the role of fibrinolytic reactions in hemostasis?
A. take place prior to platelet plug formation, to provide fibrin fragments
B. reinforce the platelet plug by creating strands of fibrin that strengthen it against dissolution by
blood flow
C. only take place in the gingival vasculature
D. are initiated at the site of vascular injury at the same time as procoagulant processes
,E. are initiated only after therapeutic intravenous administration of tissue plasminogen activator
(tPA) - CORRECT ANSWER -D
Identify the molecule with non-steroidal anti-inflammatory activity
A. acetylsalicyclic acid (ASA, aspirin)
B. acetaminophen
C. ibuprofen
D. celecoxib
E. all of the molecules listed above have non-steroidal anti-inflammatory activity - CORRECT
ANSWER -E
In thinking about the major phases of coagulation, primary hemostasis, secondary hemostasis,
and fibrinolysis: which of the following general statements is *true* in healthy individuals?
A. coagulation reactions are localized to the site of vascular injury
B. coagulation reactions are limited only the the amount of available coagulation factors
C. after being initiated, coagulation reactions can spread throughout the vasculature
D. reactions that limit coagulation begin when a thrombus reaches a specific threshold size
E. thrombi produced by the coagulation reactions remain in place after vascular healing has been
completed - CORRECT ANSWER -A
T/F: Petechiae do not blanch under pressure. - CORRECT ANSWER - True
Factor XII is a component of the _______ pathway coagulation pathway.
A. extrinsic
B. intrinsic
C. common
,D. fibrinolytic
E. none of the above - CORRECT ANSWER -B
Thrombin is typically activated at what site?
A. platelet surface
B. cytoplasm of the platelet
C. in the circulation
D. in the liver
E. on the surface of one of the fibrin strands - CORRECT ANSWER -A
Which of the following antibiotics may interfere with normal hemostasis?
A. erythromycin
B. penicillin
C. tetracycline
D. metronidazole
E. more than one of the above - CORRECT ANSWER -E
Warfarin inhibits which of the following sets of coagulation factors?
A. factors II, VIII, X, and XI
B. factors II, VII, IX, and X
C. factors II, VII, X, and XI
D. factors II, III, IX, and X
E. factors II, VII, VIII, IX, and XIIII
F. it inhibits only one coagulation factor - CORRECT ANSWER -B
, Aspirin affects platelets through the following mechanism:
A. irreversibly acetylates COX1 and COX2 to reduce production of thromboxane A2 which
inhibits platelet aggregation
B. binds platelet membrane ADP receptor P2Y12
C. binds GP IIb/IIIa
D. irreversibly acetylates COX1 and COX2 to reduce production of thromboxane A2 which
stimulates platelet aggregation
E. irreversibly acetylates COX1 only to reduce production of complement factor C3b -
CORRECT ANSWER -D
LPS from gram negative bacteria such as many of the periodontal or periapical pathogens can
contribute to the induction of disseminated intravascular coagulation (DIC). LPS does this by
which of the following mechanisms?
A. activates factor XII
B. activates factor X
C. binds to the LPS-osteoclast stimulating factor and directly activates the n-F kappa beta
pathway
D. damages endothelial cells which in turn activate basophils
E. none of the above mechanisms - CORRECT ANSWER -A
Which of the following cytokines plays a critical role in causing the differentiation of a
hematopoietic stem cell into many different types of white/red blood cell lineages?
A: IL-1/TNF-alpha
B: IL-3
C: MIP-1
D: IL-8
E: IL-10 - CORRECT ANSWER -B
