NURS 549 MIDTERM 5-
/ / /
8 EXAM WITH ANSWERS
/ / /
Cholinergic /Antagonists /drugs /have:
/
No /Affinity /and /no /Inrinsic /Activity
Affinity /and /no /Intrinsic /Activity
No /Affinity /and /have /Instrinsic /Activity
/Both
/Affinity /and /Intrinsic /Activity /- /correct /answer(s) /✔✔ /AFFINITY /AND /NO /INTRINSIC /ACTIVITY
The
/cholinergic
/antagonists /
(
/blockers)
/bind
/to
/cholinergic
/receptors /
(
/Nicotinic /
& /Muscarinic), /but /they /DO /NOT /trigger /the /usual /receptor /mediated /intracellular /effects.
•Therefore, /we /have /affinity, /BUT /NO /Intrinsic /Activity
,•The
/most
/useful
/of
/these
/drugs
/selectively
/blocks
/muscarinic /receptors /of /the /parasympathetic /nerves. /( /at /the /postganglionic /parasympathetic
/receptor /on /effector /organ /)
Muscarinic /Receptors /are /located /at /which /site /within /the /Nervous /System. /
Sympathetic /Ganglion /in /the /Autonomic /Nervous /System
Parasympathetic /Ganglion /in /the /Autonomic /Nervous /System
Parasympathetic /Effector /Organ /in /the /Autonomic /Nervous /System
Sympathetic /Effector /Organ /in /the /Autonomic /Nervous /System
Neuromuscular
/Junction
/in
/the
/Somatic
/Nervous
/System /-
/correct /answer(s) /✔✔ /Parasympathetic /Effector /Organ /in /the /Autonomic /Nervous /System
Cholinergic
/Antagonism
,/at
/Autonomic
/Nervous
/System /ganglia /for /BOTH /the /Sympathetic /and /Parasympathetic /Divisions /is /clinically /useful.
T/F /- /correct /answer(s) /✔✔ /FALSE /
•The
/most
/useful
/of
/these
/drugs
/selectively
/blocks
/muscarinic /receptors /of /the /parasympathetic /nerves. /( /at /the /postganglionic /parasympathetic
/receptor /on /effector /organ /)
•Q-
/Would
/blocking
/the
/nicotinic
/receptors
/which
/exist
/at
/both
/the
/parasympathetic
/and
/sympathetic
/ganglion
/be
/clinically
/useful? /Answer /= /NO /( /ganglionic /blockers /are /not /selective /enough /for /clinical /benefit)
, •Remember-
/DUAL
/INNERVATION /-
/when
/parasympathetic
/influence
/is /antagonized /, /the /sympathetic /influence /is /unopposed /àincreased /sympathetic /influence.
A
/Cholinergic
/Antagonist
/that
/is
/Surmountable,
/can
/be
/overcome
/with
/higer
/concentrations
/of
/Agonistic
/Drug /,
/and /
a
/higher
/EC50
/for
/the
/graded
/Dose
/Response
/Curve
/is
/observed
/is
/categorized /as /___________________________, /while /a /Cholinergic /Antagonist /that /is /Non-
/ / /
8 EXAM WITH ANSWERS
/ / /
Cholinergic /Antagonists /drugs /have:
/
No /Affinity /and /no /Inrinsic /Activity
Affinity /and /no /Intrinsic /Activity
No /Affinity /and /have /Instrinsic /Activity
/Both
/Affinity /and /Intrinsic /Activity /- /correct /answer(s) /✔✔ /AFFINITY /AND /NO /INTRINSIC /ACTIVITY
The
/cholinergic
/antagonists /
(
/blockers)
/bind
/to
/cholinergic
/receptors /
(
/Nicotinic /
& /Muscarinic), /but /they /DO /NOT /trigger /the /usual /receptor /mediated /intracellular /effects.
•Therefore, /we /have /affinity, /BUT /NO /Intrinsic /Activity
,•The
/most
/useful
/of
/these
/drugs
/selectively
/blocks
/muscarinic /receptors /of /the /parasympathetic /nerves. /( /at /the /postganglionic /parasympathetic
/receptor /on /effector /organ /)
Muscarinic /Receptors /are /located /at /which /site /within /the /Nervous /System. /
Sympathetic /Ganglion /in /the /Autonomic /Nervous /System
Parasympathetic /Ganglion /in /the /Autonomic /Nervous /System
Parasympathetic /Effector /Organ /in /the /Autonomic /Nervous /System
Sympathetic /Effector /Organ /in /the /Autonomic /Nervous /System
Neuromuscular
/Junction
/in
/the
/Somatic
/Nervous
/System /-
/correct /answer(s) /✔✔ /Parasympathetic /Effector /Organ /in /the /Autonomic /Nervous /System
Cholinergic
/Antagonism
,/at
/Autonomic
/Nervous
/System /ganglia /for /BOTH /the /Sympathetic /and /Parasympathetic /Divisions /is /clinically /useful.
T/F /- /correct /answer(s) /✔✔ /FALSE /
•The
/most
/useful
/of
/these
/drugs
/selectively
/blocks
/muscarinic /receptors /of /the /parasympathetic /nerves. /( /at /the /postganglionic /parasympathetic
/receptor /on /effector /organ /)
•Q-
/Would
/blocking
/the
/nicotinic
/receptors
/which
/exist
/at
/both
/the
/parasympathetic
/and
/sympathetic
/ganglion
/be
/clinically
/useful? /Answer /= /NO /( /ganglionic /blockers /are /not /selective /enough /for /clinical /benefit)
, •Remember-
/DUAL
/INNERVATION /-
/when
/parasympathetic
/influence
/is /antagonized /, /the /sympathetic /influence /is /unopposed /àincreased /sympathetic /influence.
A
/Cholinergic
/Antagonist
/that
/is
/Surmountable,
/can
/be
/overcome
/with
/higer
/concentrations
/of
/Agonistic
/Drug /,
/and /
a
/higher
/EC50
/for
/the
/graded
/Dose
/Response
/Curve
/is
/observed
/is
/categorized /as /___________________________, /while /a /Cholinergic /Antagonist /that /is /Non-
