Questions and Answers Graded A+ 2025
,NR507 Edapt Week 5 Liver Cirrhosis
Introduction to Liver Cirrhosis
Cirrhosis of the liver is a condition characterized by the progressive scarring of liver tissue, typically
resulting from long-term liver inflammation and injury. This scarring can lead to impaired liver function
and potentially serious complications. Chronic liver diseases such as hepatitis C, hepatitis B, and long-
term alcohol abuse are common causes of cirrhosis.
The liver is involved in the metabolism of carbohydrates, proteins, and fats; detoxification of harmful
substances; storage of vitamins, minerals, and glycogen; production of bile for digestion; and filtration
of blood.
Insulin is produced by the pancreas. Bile is stored in the gallbladder.
, Liver damage often begins with injury to hepatocytes, the liver cells responsible for various metabolic
functions. This injury triggers an inflammatory response, leading to the accumulation of immune cells
and cytokines in the liver. Chronic inflammation can then stimulate the activation of hepatic stellate
cells, which are responsible for producing collagen and other extracellular matrix proteins, leading to
the development of fibrosis. If the underlying cause of liver damage persists, fibrosis can progress to
cirrhosis, characterized by extensive scarring and disruption of liver architecture.
Enlargement of the liver is common in chronic liver disease, including cirrhosis, and may be palpable
on physical examination. Accumulation of fluid in the abdominal cavity is a common complication of
liver cirrhosis and can be assessed through physical examination and imaging studies. Enlargement of
breast tissue in males can occur due to hormonal imbalances associated with liver dysfunction.
Gastrointestinal bleeding, particularly from esophageal varices, is a serious complication of liver
cirrhosis and can manifest as bloody or tarry stools (melena).
While hypertension can be associated with chronic liver disease, it is not typically a direct consequence
of liver cirrhosis. It may be more related to other comorbidities or underlying causes of liver disease,
such as obesity or alcohol misuse.