CJE Pharmacology Review QUESTIONS WITH ANSWERS
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1.penicillins: i.e. ampicillin, amoxicillin, methicillin (Unasyn, \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
Augmentin, Zosyn) moa: interferes with synthesis of bacterial \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
cell walls -> lysis
\|\|\| \|\|\| \|\|\|
adverse effects....superinfections, allergic \|\|\| \|\|\| \|\|\|
rxn warnings: pts with renal problems =
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
`dosage
nursing considerations....monitor respiratory, education on adherence,
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
take w/ food to ` GI s/s
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2.Cephalosporins: i.e. Rocephin, Keflex \|\|\| \|\|\| \|\|\|
moa: prevents synthesis of bacterial walls, lysis
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adverse effects....superinfections, GI upset, CNS problems,
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
nephrotoxicity
precautions....do not mix with Ca (i.e. ringer's) can ^ precipitation in \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\
lungs/kidneys, penicillin allergies \|\|\| \|\|\|
1 \|\|\|/ \
|\|\|13
, nursing interventions...monitor pulmonary/renal fxn, can
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
interact w/anticoags = \|\|\| \|\|\|
^bleed risk, safe for pregnancy \|\|\| \|\|\| \|\|\| \|\|\|
3.tetracyclines: i.e. doxycycline, tetracycline, \|\|\| \|\|\| \|\|\| \|\|\|
minocycline moa: inhibits \|\|\| \|\|\| \|\|\|
protein synthesis/bacterial cell growth
\|\|\| \|\|\| \|\|\|
adverse effects....not safe for pregnancy (^ risk for hepatotoxicity), sun
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
sensitivity, hepatotoxicity, weakened bones \|\|\| \|\|\| \|\|\|
nursing interventions....education on ^sun sensitivity,
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
avoid antacids/multivitamins,, can interact with birth control
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
4.macrolides: typically prescribed with other antibiotics, i.e. \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
erythromycin, clar- ithromycin, azithromycin \|\|\| \|\|\| \|\|\|
moa: interferes w/ protein synthesis
\|\|\| \|\|\| \|\|\| \|\|\|
adverse effects: ECG changes, hepatotoxic, n/v w/ no food
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
warnings. caution w/ "-mycin" drugs, torsade de pointes, no azithromycin \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
for hepat- \|\|\|
ic dysfunction
\|\|\|
2 \|\|\|/ \
|\|\|13
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
1.penicillins: i.e. ampicillin, amoxicillin, methicillin (Unasyn, \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
Augmentin, Zosyn) moa: interferes with synthesis of bacterial \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
cell walls -> lysis
\|\|\| \|\|\| \|\|\|
adverse effects....superinfections, allergic \|\|\| \|\|\| \|\|\|
rxn warnings: pts with renal problems =
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
`dosage
nursing considerations....monitor respiratory, education on adherence,
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
take w/ food to ` GI s/s
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
2.Cephalosporins: i.e. Rocephin, Keflex \|\|\| \|\|\| \|\|\|
moa: prevents synthesis of bacterial walls, lysis
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
adverse effects....superinfections, GI upset, CNS problems,
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
nephrotoxicity
precautions....do not mix with Ca (i.e. ringer's) can ^ precipitation in \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\
lungs/kidneys, penicillin allergies \|\|\| \|\|\|
1 \|\|\|/ \
|\|\|13
, nursing interventions...monitor pulmonary/renal fxn, can
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
interact w/anticoags = \|\|\| \|\|\|
^bleed risk, safe for pregnancy \|\|\| \|\|\| \|\|\| \|\|\|
3.tetracyclines: i.e. doxycycline, tetracycline, \|\|\| \|\|\| \|\|\| \|\|\|
minocycline moa: inhibits \|\|\| \|\|\| \|\|\|
protein synthesis/bacterial cell growth
\|\|\| \|\|\| \|\|\|
adverse effects....not safe for pregnancy (^ risk for hepatotoxicity), sun
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
sensitivity, hepatotoxicity, weakened bones \|\|\| \|\|\| \|\|\|
nursing interventions....education on ^sun sensitivity,
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
avoid antacids/multivitamins,, can interact with birth control
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
4.macrolides: typically prescribed with other antibiotics, i.e. \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
erythromycin, clar- ithromycin, azithromycin \|\|\| \|\|\| \|\|\|
moa: interferes w/ protein synthesis
\|\|\| \|\|\| \|\|\| \|\|\|
adverse effects: ECG changes, hepatotoxic, n/v w/ no food
\|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
warnings. caution w/ "-mycin" drugs, torsade de pointes, no azithromycin \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\| \|\|\|
for hepat- \|\|\|
ic dysfunction
\|\|\|
2 \|\|\|/ \
|\|\|13
