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USMLE Step 2 – Surgery Questions and Correct Answers High-Yield Compilation | 1000+ Clinical Cases & Explanations. 2025/2026.

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This document contains over 1000 high-yield USMLE Step 2 Surgery questions and answers, organized by topic and system. Covers trauma, GI, urology, orthopedics, vascular, and perioperative management, with detailed differential diagnoses, clinical pearls, and work-up plans. Ideal for mastering clinical reasoning and acing shelf exams and Step 2 CK.

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,USMLE Step 2 – Surgery Questions and
Correct Answers High-Yield Compilation
| 1000+ Clinical Cases & Explanations.
2025/2026.

Q001. assessing the airway

A001. patient conscious and speaking --> airway present; neck hematoma or emphysema -->
patient will loose airway and should be secured; patient unconscious or noisy breathing --> need to
secure airway

Q002. airway procedures

A002. in the field --> cricothyroidotomy; in the ER --> orotracheal intubation with pulse oximetry;
cervical spine injury --> orotracheal or nasotracheal intubation; maxillofacial injuries -->
cricothyroidotomy or percutaneous tracheostomy

Q003. signs of shock

A003. systolic pressure < 90mmHg; fast feeble pulse; low urinary output in patient who is cold, pale,
shivering, sweating, thirsty

Q004. traumatic causes of shock

A004. bleeding; pericardial tamponade; tension pneumothorax; hypovolemic shock cannot happen from
intracranial bleeding

Q005. hemorrhagic shock Vs. pericardial tamponade Vs. tension pneumothorax

A005. hemorrhage --> CVP is low (empty veins); cardiac tamponade and tension pneumothorax -->
CVP high (distended neck veins); pericardial tamponade --> no respiratory distress; tension
pneumothorax --> severe respiratory distress, unilateral loss of breath sounds, hyperresonance and
mediastinum/tracheal deviation

Q006. hemorrhagic shock in penetrating injuries management

A006. surgical intervention first to stop the bleeding then volume replacement

Q007. non-hemorrhagic shock management

A007. fluid replacement first with 2L of Ringer followed by packed red cells until urine is 0.5-2ml/kg/h
and CVP does not exceed 15mmHg

Q008. pericardial tamponade shock management

,A008. clinical diagnosis, don't order x-rays, if unclear order sonogram; prompt evacuation of pericardial
sac by pericardiocentesis, tube, pericardial window or open thoracotomy; fluids and red cells while
evacuation is being done

Q009. tension pneumothorax shock management

A009. clinical diagnosis, don't order x-rays or wait blood gases;; big needle or IV catheter into pleural
space;; follow with chest tube connected to underwater seal

Q010. preferred route of fluid resuscitation in shock

A010. 2 16-gauge peripheral IV lines; if not --> percutaneous femoral vein catheter or saphenous vein
cut-down

Q011. types of head trauma

A011. penetrating; linear skull fracture; base of skull fracture; acute epidural and subdural hematoma;
diffuse axonal injury; chronic subdural hematoma

Q012. head trauma + loss of consciousness

A012. CT of head required to rule out hematoma; if negative CT --> send home and wake up
frequently in next 24 hours

Q013. base of skull fracture

A013. signs are raccoon eyes, rhinorrhea, otorrhea, ecchymosis behind ear; no antibiotics indicated;
cervical spine CT to assess integrity; if has loss consciousness --> head CT; if signs of base fracture --
> neck CT also

Q014. neurologic damage from trauma

A014. from initial blow, or later hematoma or increased intracranial pressure; treat hematoma with
surgery; treat pressure with drugs (diuretics)

Q015. acute epidural hematoma

A015. sequence of trauma, unconsciousness, lucid interval, gradual coma, fixed dilated pupil,
contralateral hemiparesis; CT shows biconvex, lens-shaped hematoma; cure is emergency craniotomy

Q016. acute subdural hematoma

A016. sequence of trauma, unconsciousness, lucid interval, gradual coma mcuh more severe; CT shows
semilunar hematoma; if midline deviated --> craniotomy; else --> treat increased intracranial
pressure

Q017. diffuse axonal injury from head trauma

A017. CT shows blurring of gray-white matter interface and small punctuate hemorrhages; if no
hematoma, no surgery; decrease ICP

Q018. chronic subdural hematoma

, A018. in elderly or severe alcoholics; a tear in venous sinuses with hematoma over days or weeks; CT
and surgical evacuation is cure

Q019. penetrating neck trauma exploration indications

A019. expanding hematoma; deteriorating vital signs; esophageal or tracheal injury (coughing,
hemoptysis); gunshot to middle neck

Q020. neck gunshot wounds

A020. middle zone --> exploration; upper zone --> arteriogram; base of neck --> arteriogram,
esophagogram (barium), esophagoscopy, and bronchoscopy before surgery

Q021. neck stab wounds

A021. if upper and middle zones in asymptomatic patients --> observation

Q022. blunt neck trauma

A022. if neurologic deficits or pain to local palpation of cervical spine --> cervical spine CT

Q023. types of chest trauma

A023. rib fracture; pneumothorax; hemothorax; blunt trauma; sucking chest wounds; flail chest;
pulmonary contusion; myocardial contusion; traumatic rupture of diaphragm, aorta, trachea or
bronchus; air and fat embolism

Q024. rib fracture

A024. can be deadly in elderly; progression of pain --> hypoventilation --> atelectasis -->
pneumonia; treat with nerve block

Q025. plain pneumothorax

A025. penetrating trauma due to broken rib or weapon; moderate shortness of breath, unilateral
absence of breath sounds and hyperresonance; do chest x-ray, place chest tube, connect to underwater
seal

Q026. hemothorax

A026. penetrating trauma due to broken rib or weapon; moderate shortness of breath; unilateral
absence of breath sounds and dullness to percussion; do chest x-ray and evacuate blood by chest tube;
surgery indicated if --> recover 1.5L of blood with insertion of chest tube or 600ml in tube drainage
over 6 hours

Q027. blunt chest trauma

A027. monitor hidden injuries; blood gases,; chest x-ray,; cardiac enzymes,; ECG

Q028. sucking chest wound

A028. flap sucks air in with inspiration and closes in expiration; treat with occlusive dressing to allow air
out but not in
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