HESI A2 Anatomy and Physiology Practice Exam
2025 - 80 Questions
Comprehensive Anatomy and Physiology Study Guide for Nursing School
Applicants
Includes 80 Practice Questions with Detailed Answer Key
Covers Human Body Systems, Tissues, and Physiological Processes
Updated for the 2025 HESI A2 Exam
Contents
1 Instructions 2
2 Anatomy and Physiology (80 Questions) 2
3 Answer Key with Explanations 11
1
,1 Instructions
This practice exam is designed to prepare you for the Anatomy and Physiology section of
the HESI A2 Entrance Exam 2025. It includes 80 multiple-choice questions covering hu-
man body systems, tissues, and physiological processes. Read each question carefully and
select the best answer from the four options provided. An answer key with explanations
is included at the end.
• Time Limit: Approximately 40–50 minutes.
• Materials: No additional materials required.
• Scoring: Each question is worth 1 point. No penalty for incorrect answers.
2 Anatomy and Physiology (80 Questions)
1. What is the primary function of the skeletal system?
a) Transport oxygen
b) Support and protect the body
c) Digest nutrients
d) Regulate temperature
2. Which bone is located in the upper arm?
a) Radius
b) Ulna
c) Humerus
d) Femur
3. What type of joint is the knee?
a) Ball-and-socket
b) Hinge
c) Pivot
d) Gliding
4. Which muscle type is under voluntary control?
a) Smooth
b) Cardiac
c) Skeletal
d) Involuntary
5. Where is the biceps brachii muscle located?
a) Thigh
b) Upper arm
c) Back
d) Abdomen
6. What is the primary function of red blood cells?
a) Fight infection
b) Carry oxygen
c) Clot blood
d) Produce antibodies
2
, 7. Which chamber of the heart pumps blood into the aorta?
a) Right atrium
b) Left atrium
c) Right ventricle
d) Left ventricle
8. What is the role of the lymphatic system?
a) Regulate blood sugar
b) Maintain fluid balance
c) Produce hormones
d) Digest fats
9. Which organ is primarily responsible for filtering blood?
a) Liver
b) Kidney
c) Spleen
d) Pancreas
10. What is the functional unit of the kidney?
a) Neuron
b) Nephron
c) Alveolus
d) Osteon
11. Which part of the respiratory system is the site of gas exchange?
a) Trachea
b) Bronchi
c) Alveoli
d) Pharynx
12. What muscle is primarily responsible for breathing?
a) Diaphragm
b) Intercostals
c) Pectoralis
d) Rectus abdominis
13. Which organ secretes digestive enzymes into the small intestine?
a) Stomach
b) Pancreas
c) Liver
d) Gallbladder
14. What is the primary site of nutrient absorption?
a) Stomach
b) Small intestine
c) Large intestine
d) Esophagus
15. Which part of the brain controls balance and coordination?
a) Cerebrum
b) Cerebellum
3
2025 - 80 Questions
Comprehensive Anatomy and Physiology Study Guide for Nursing School
Applicants
Includes 80 Practice Questions with Detailed Answer Key
Covers Human Body Systems, Tissues, and Physiological Processes
Updated for the 2025 HESI A2 Exam
Contents
1 Instructions 2
2 Anatomy and Physiology (80 Questions) 2
3 Answer Key with Explanations 11
1
,1 Instructions
This practice exam is designed to prepare you for the Anatomy and Physiology section of
the HESI A2 Entrance Exam 2025. It includes 80 multiple-choice questions covering hu-
man body systems, tissues, and physiological processes. Read each question carefully and
select the best answer from the four options provided. An answer key with explanations
is included at the end.
• Time Limit: Approximately 40–50 minutes.
• Materials: No additional materials required.
• Scoring: Each question is worth 1 point. No penalty for incorrect answers.
2 Anatomy and Physiology (80 Questions)
1. What is the primary function of the skeletal system?
a) Transport oxygen
b) Support and protect the body
c) Digest nutrients
d) Regulate temperature
2. Which bone is located in the upper arm?
a) Radius
b) Ulna
c) Humerus
d) Femur
3. What type of joint is the knee?
a) Ball-and-socket
b) Hinge
c) Pivot
d) Gliding
4. Which muscle type is under voluntary control?
a) Smooth
b) Cardiac
c) Skeletal
d) Involuntary
5. Where is the biceps brachii muscle located?
a) Thigh
b) Upper arm
c) Back
d) Abdomen
6. What is the primary function of red blood cells?
a) Fight infection
b) Carry oxygen
c) Clot blood
d) Produce antibodies
2
, 7. Which chamber of the heart pumps blood into the aorta?
a) Right atrium
b) Left atrium
c) Right ventricle
d) Left ventricle
8. What is the role of the lymphatic system?
a) Regulate blood sugar
b) Maintain fluid balance
c) Produce hormones
d) Digest fats
9. Which organ is primarily responsible for filtering blood?
a) Liver
b) Kidney
c) Spleen
d) Pancreas
10. What is the functional unit of the kidney?
a) Neuron
b) Nephron
c) Alveolus
d) Osteon
11. Which part of the respiratory system is the site of gas exchange?
a) Trachea
b) Bronchi
c) Alveoli
d) Pharynx
12. What muscle is primarily responsible for breathing?
a) Diaphragm
b) Intercostals
c) Pectoralis
d) Rectus abdominis
13. Which organ secretes digestive enzymes into the small intestine?
a) Stomach
b) Pancreas
c) Liver
d) Gallbladder
14. What is the primary site of nutrient absorption?
a) Stomach
b) Small intestine
c) Large intestine
d) Esophagus
15. Which part of the brain controls balance and coordination?
a) Cerebrum
b) Cerebellum
3
