RX455 Pregnancy and Lactation. Exam 2025
Questions and Answers
Which of the following is a pharmacokinetic parameter that should be considered when
calculating an appropriate dosing regimen for a pregnant patient?
a. Decreased renal clearance
b. Decreased gastric acidity
c. Increased plasma volume
d. Increased protein binding - ANS Increased plasma volume
Which of the following best summarizes changes in hepatic metabolism that occur during
pregnancy?
a. Decreased activity of cytochrome P450 isoenzymes
b. Increased activity of cytochrome P450 isoenzymes
c. No change in activity of cytochrome P450 isoenzymes
d. Variable effects on activity of cytochrome P450 isoenzymes - ANS Variable effects on
activity of cytochrome P450 isoenzymes
Which of the following medications would be most likely to cross the placenta and result in
fetal exposure?
a. A drug that is a weak acid with a molecular weight of 500 Da
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, b. A lipophilic drug with a molecular weight of 300 Da
c. A hydrophilic drug with a molecular weight of 900 Da
d. A drug that is a weak base with a molecular weight of 1200 Da - ANS A lipophilic drug with
a molecular weight of 300 Da
Select the best drug therapy for treating nausea in a pregnant female.
a. Calcium
b. Vitamin B6
c. Ondansetron
d. Metoclopramide - ANS Vitamin B6
Select the best drug therapy for treating constipation in a pregnant female.
a. Castor oil
b. Sodium phosphate
c. Mineral oil
d. Polyethylene glycol - ANS Polyethylene glycol
Select the best drug therapy for treating insomnia in a pregnant female.
a. Doxylamine
b. Clonazepam
c. Zolpidem
d. Eszopiclone - ANS Doxylamine
Select the best drug therapy for treating hypertension in a pregnant female.
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Questions and Answers
Which of the following is a pharmacokinetic parameter that should be considered when
calculating an appropriate dosing regimen for a pregnant patient?
a. Decreased renal clearance
b. Decreased gastric acidity
c. Increased plasma volume
d. Increased protein binding - ANS Increased plasma volume
Which of the following best summarizes changes in hepatic metabolism that occur during
pregnancy?
a. Decreased activity of cytochrome P450 isoenzymes
b. Increased activity of cytochrome P450 isoenzymes
c. No change in activity of cytochrome P450 isoenzymes
d. Variable effects on activity of cytochrome P450 isoenzymes - ANS Variable effects on
activity of cytochrome P450 isoenzymes
Which of the following medications would be most likely to cross the placenta and result in
fetal exposure?
a. A drug that is a weak acid with a molecular weight of 500 Da
Pg. 1 Copyright © 2025 Jasonmcconell. ALL RIGHTS RESERVED.
, b. A lipophilic drug with a molecular weight of 300 Da
c. A hydrophilic drug with a molecular weight of 900 Da
d. A drug that is a weak base with a molecular weight of 1200 Da - ANS A lipophilic drug with
a molecular weight of 300 Da
Select the best drug therapy for treating nausea in a pregnant female.
a. Calcium
b. Vitamin B6
c. Ondansetron
d. Metoclopramide - ANS Vitamin B6
Select the best drug therapy for treating constipation in a pregnant female.
a. Castor oil
b. Sodium phosphate
c. Mineral oil
d. Polyethylene glycol - ANS Polyethylene glycol
Select the best drug therapy for treating insomnia in a pregnant female.
a. Doxylamine
b. Clonazepam
c. Zolpidem
d. Eszopiclone - ANS Doxylamine
Select the best drug therapy for treating hypertension in a pregnant female.
Pg. 2 Copyright © 2025 Jasonmcconell. ALL RIGHTS RESERVED.
