MIC319 Final Exam 2025 Questions and
Answers
False on the consequence of not having NK cells
a. Easily succumb to viral infection
b. Higher incidence of cancer
c. Cell mediated killing of cells expressing high levels of MMC-I in the cell surface
d. Impaired anti-viral innate immunity - ANS c. Cell mediated killing of cells expressing high
levels of MMC-I in the cell surface
Indicate false about evasion of the immune response by viruses
a. Many viruses carry mechanism to downregulate the MMC Class-! To avoid immune
recognition.
b. Evasion of the innate immune response by viruses can prevent all disease symptoms.
c. Many pathogenic viruses carry anti-apoptotic proteins
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,d. Viruses have evolved mechanism to evade killing by NK cells - ANS b. Evasion of the innate
immune response by viruses can prevent all disease symptoms.
Identify the false statement about the apoptosome and it formation
a. Cytochrome C released by the mitochondria catalyzes the oligomerization of APAF with
Caspase-9 to form the apoptosome
b. It can be directly activated by death receptors via DISC formation and activation of Caspase-8
c. It is a molecular killing machine that massively activates Caspase-3
d. It is antagonized by anti-apoptotic IAP proteins - ANS b. It can be directly activated by
death receptors via DISC formation and activation of Caspase-8
Indicate False about TNF-alpha, an inflammatory cytokine that in spite of binding a receptor
containing a dead domain does not cause apoptosis in many cell types:
a. TNF-alpha treated cells survive because TNF-alpha can't activate the extrinsic apoptosis
pathway through DISC formation
b. TNF-alpha activation of the NFKB pathway leads to transcription of the anti apoptotic Bcl-2
member Bcl-XL and the IAP apoptosome inhibitor.
c. The TNF-alpha receptor activates DISC leading to caspase 8 activation
d. TNF-alpha treated cells can show cleavage of caspase 3 - ANS a. TNF-alpha treated cells
survive because TNF-alpha can't activate the extrinsic apoptosis pathway through DISC
formation
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,Indicate the only mechanism unique to the extrinsic pathway of apoptosis
a. Death receptor recruitment of the adaptor FADD and caspase 8 with formation of the DISC
signaling complex
b. Mitochondrial release of Cytochrome C leading to apoptosome formation
c. Cleavage of pro caspase 3
d. Phagocytosis of apoptotic bodies - ANS a. Death receptor recruitment of the adaptor
FADD and caspase 8 with formation of the DISC signaling complex
True about symptoms of viral disease
a. Could be caused by direct cytotoxicity of viruses on host cells
b. Caused by undesirable effects of the innate immune response
c. Could be caused by uncontrolled inflammatory responses to viruses
d. All answers provided for this questions are correct - ANS d. All answers provided for this
questions are correct
Which is the best explanation about the nature of the viral gene inactivated by the mutation?
a. It regulates the transcription of an anti-apoptotic MCMC viral gene
b. It inhibits inflammasome formation by MCMV DNA
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, c. Inhibits induction of the Type 1 IFN response.
d. It inhibits host cell protein synthesis - ANS a. It regulates the transcription of an anti-
apoptotic MCMC viral gene
Identify the statement that is not true about apoptosis
a. It leads to massive DAMP release and inflammation
b. It is an active, programmed process that requires ATP
c. It leads to blebbing and apoptotic body formation
d. Apoptotic bodies express eat me signals in the cell surface - ANS d. Apoptotic bodies
express eat me signals in the cell surface
Identify the false statement about Bcl-2 family of proteins:
a. Anti-apoptotic members such as Bcl-2 members antagonize pore formation by pro-apoptotic
members Bax and Bak that would lead to release of Cytochrome C
b. They are the key component of the apoptosome
c. Some pro-apoptotic members such as Bid and its cleavage product, tbid, are a way whereby
the extrinsic pathway can regulate the intrinsic pathway
d. Anti-apoptotic members can be upregulated by NfkB - ANS b. They are the key component
of the apoptosome
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Answers
False on the consequence of not having NK cells
a. Easily succumb to viral infection
b. Higher incidence of cancer
c. Cell mediated killing of cells expressing high levels of MMC-I in the cell surface
d. Impaired anti-viral innate immunity - ANS c. Cell mediated killing of cells expressing high
levels of MMC-I in the cell surface
Indicate false about evasion of the immune response by viruses
a. Many viruses carry mechanism to downregulate the MMC Class-! To avoid immune
recognition.
b. Evasion of the innate immune response by viruses can prevent all disease symptoms.
c. Many pathogenic viruses carry anti-apoptotic proteins
Pg. 1 Copyright © 2025 Jasonmcconell. ALL RIGHTS RESERVED.
,d. Viruses have evolved mechanism to evade killing by NK cells - ANS b. Evasion of the innate
immune response by viruses can prevent all disease symptoms.
Identify the false statement about the apoptosome and it formation
a. Cytochrome C released by the mitochondria catalyzes the oligomerization of APAF with
Caspase-9 to form the apoptosome
b. It can be directly activated by death receptors via DISC formation and activation of Caspase-8
c. It is a molecular killing machine that massively activates Caspase-3
d. It is antagonized by anti-apoptotic IAP proteins - ANS b. It can be directly activated by
death receptors via DISC formation and activation of Caspase-8
Indicate False about TNF-alpha, an inflammatory cytokine that in spite of binding a receptor
containing a dead domain does not cause apoptosis in many cell types:
a. TNF-alpha treated cells survive because TNF-alpha can't activate the extrinsic apoptosis
pathway through DISC formation
b. TNF-alpha activation of the NFKB pathway leads to transcription of the anti apoptotic Bcl-2
member Bcl-XL and the IAP apoptosome inhibitor.
c. The TNF-alpha receptor activates DISC leading to caspase 8 activation
d. TNF-alpha treated cells can show cleavage of caspase 3 - ANS a. TNF-alpha treated cells
survive because TNF-alpha can't activate the extrinsic apoptosis pathway through DISC
formation
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,Indicate the only mechanism unique to the extrinsic pathway of apoptosis
a. Death receptor recruitment of the adaptor FADD and caspase 8 with formation of the DISC
signaling complex
b. Mitochondrial release of Cytochrome C leading to apoptosome formation
c. Cleavage of pro caspase 3
d. Phagocytosis of apoptotic bodies - ANS a. Death receptor recruitment of the adaptor
FADD and caspase 8 with formation of the DISC signaling complex
True about symptoms of viral disease
a. Could be caused by direct cytotoxicity of viruses on host cells
b. Caused by undesirable effects of the innate immune response
c. Could be caused by uncontrolled inflammatory responses to viruses
d. All answers provided for this questions are correct - ANS d. All answers provided for this
questions are correct
Which is the best explanation about the nature of the viral gene inactivated by the mutation?
a. It regulates the transcription of an anti-apoptotic MCMC viral gene
b. It inhibits inflammasome formation by MCMV DNA
Pg. 3 Copyright © 2025 Jasonmcconell. ALL RIGHTS RESERVED.
, c. Inhibits induction of the Type 1 IFN response.
d. It inhibits host cell protein synthesis - ANS a. It regulates the transcription of an anti-
apoptotic MCMC viral gene
Identify the statement that is not true about apoptosis
a. It leads to massive DAMP release and inflammation
b. It is an active, programmed process that requires ATP
c. It leads to blebbing and apoptotic body formation
d. Apoptotic bodies express eat me signals in the cell surface - ANS d. Apoptotic bodies
express eat me signals in the cell surface
Identify the false statement about Bcl-2 family of proteins:
a. Anti-apoptotic members such as Bcl-2 members antagonize pore formation by pro-apoptotic
members Bax and Bak that would lead to release of Cytochrome C
b. They are the key component of the apoptosome
c. Some pro-apoptotic members such as Bid and its cleavage product, tbid, are a way whereby
the extrinsic pathway can regulate the intrinsic pathway
d. Anti-apoptotic members can be upregulated by NfkB - ANS b. They are the key component
of the apoptosome
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