TEST BANK
Cellular and Molecular Immunology
Abul Abbas, Andrew Lichtman, and Shiv Pillai
10th Edition
e
PlusBay.Plus
,Table of Contents
e e
Chaptere01ePropertieseandeOvervieweofeImmuneeResponses 1
Chaptere02eCellseandeTissueseofetheeImmuneeSystem 3
Chaptere03eLeukocyteeCirculationeandeMigrationeIntoeTissues 6
Chaptere04eInnateeImmunity 10
Chaptere05eAntibodieseandeAntigens 17
Chaptere06eAntigenePresentationetoeTeLymphocyteseandetheeFunctionseofeMajor
HistocompatibilityeComplexeMolecules 20
Chaptere07eImmuneeReceptorseandeSignaleTransduction 27
Chaptere08eLymphocyteeDevelopmenteandeAntigeneReceptoreGeneeRearrangement 30
Chaptere09eActivationeofeTeLymphocytes 34
Chaptere10eDifferentiationeandeFunctionseofeCD4+eEffectoreTeCells 38
Chaptere11eDifferentiationeandeFunctionseofeCD8+eEffectoreTeCells 42
Chaptere12eBeCelleActivationeandeAntibodyeProduction 46
Chaptere13eEffectoreMechanismseofeHumoraleImmunity 52
Chaptere14eSpecializedeImmunityeateEpithelialeBarrierseandeineImmuneePrivilegedeTissues 56
Chaptere15eImmunologiceToleranceeandeAutoimmunity 62
Chaptere16eImmunityetoeMicrobes 67
Chaptere17eTransplantationeImmunology 72
Chaptere18eTumoreImmunology 77
Chaptere19eHypersensitivityeDisorders 81
Chaptere20eAllergy 86
Chaptere21ePrimaryeandeAcquiredeImmunodeficiencies 89
PlusBay.Plus
,Chapter 01: Properties and Overview of Immune Responses
e e e e e e e
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
e e e e e e e e e
MULTIPLEeCHOICE
1. Theeprincipalefunctioneofetheeimmuneesystemeis:
a. Defenseeagainstecancer
b. Repaireofeinjuredetissues
c. Defenseeagainstemicrobialeinfections
d. Preventioneofeinflammatoryediseases
e. Protectioneagainsteenvironmentaletoxins
ANS:e e C
Theeimmuneesystemehaseevolvedeinetheesettingeofeselectiveepressureseimposedebyemicrobialeinfec
tions.eAlthougheimmuneeresponsesetoecanceremayeoccur,etheeconceptethate“immunosurveillance”e
againstecancereiseaeprincipalefunctioneofetheeimmuneesystemeisecontroversial.eRepaireofeinjuredetis
suesemayebeeaesecondaryeconsequenceeofetheeimmuneeresponseseandeinflammation.eAlthoughethee
immuneesystemehaseregulatoryefeaturesethateareeneededetoepreventeexcessiveeinflammation,eprev
entioneofeinflammatoryediseaseseisenoteaeprimaryefunction.eTheeimmuneesystemecaneprotecteagain
stemicrobialetoxins,ebuteitegenerallyedoesenoteoffereprotectioneagainstetoxinseofenonbiologiceorigin
.
2. Whicheofetheefollowingeinfectiousediseasesewasepreventedebyetheefirstesuccessfulev
accination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:e e C
Ine1798,eEdwardeJennerereportedetheefirsteintentionalesuccessfulevaccination,ewhichewaseagain
stesmallpoxeineaeboy,eusingematerialefrometheecowpoxepustuleseofeaemilkmaid.eIne1980,esmallpo
xewasereportedetoebeeeradicatedeworldwideebyeaevaccinationeprogram.eEffectiveevaccineseagai
nstetetanusetoxin,erubellaevirus,eandepoliovirusewereedevelopedeinethee20thecenturyeandeareewid
elyeused.eThereeisenoeeffectiveevaccineeagainsteMycobacteriumetuberculosis.
3. Whicheofetheefollowingeiseaeuniqueepropertyeofetheeadaptiveeimmuneesystem?
a. Highlyediverseerepertoireeofespecificitieseforeantigens
b. Self-nonselfediscrimination
c. Recognitioneofemicrobialestructuresebyebothecell-associatedeandesolubleereceptors
d. Protectioneagainsteviraleinfections
e. Responsesethatehaveetheesameekineticseandemagnitudeeonerepeatedeexposureetoethees
ameemicrobe
ANS:e e A
PlusBay.Plus
, HighlyediverseerepertoireseofespecificitieseforeantigenseareefoundeonlyeineTeandeBelymphocytes
,ewhicheareetheecentralecellularecomponentseofetheeadaptiveeimmuneesystem.eBothetheeinnateean
detheeadaptiveeimmuneesystemseuseecell-
associatedeandesolubleereceptorsetoerecognizeemicrobes,edisplayesomeedegreeeofeself-
nonselfediscrimination,eandeprotecteagainsteviruses.eOnerepeatedeexposureetoetheesameemicrob
e,etheeadaptiveeimmuneeresponseebecomesemoreerapideandeofegreateremagnitude;ethiseisetheema
nifestationeofememory.
4. AntibodieseandeTelymphocyteseareetheerespectiveemediatorseofewhichetwoetypeseofei
mmunity?
a. Innateeandeadaptive
b. Passiveeandeactive
c. Specificeandenonspecific
d. Humoraleandecell-mediated
e. Adulteandeneonatal
ANS:e e D
BotheBeandeTelymphocyteseareeprincipalecomponentseofeadaptiveeimmunity.eBelymphocytesepr
oduceeantibodies,ewhicheareetheerecognitioneandeeffectoremoleculeseofehumoraleimmuneerespo
nsesetoeextracellularepathogens.eTecellserecognizeeandepromoteeeradicationeofeintracellularepath
ogenseinecell-
mediatedeimmunity.ePassiveeandeactiveeimmunityebothecanebeemediatedebyeeithereBeoreTelymph
ocytes.eSpecificeimmunityeiseanotheretermeforeadaptiveeimmunity.eBotheBeandeTelymphocytesep
articipateeineadulteadaptiveeimmunityebuteareestilledevelopingeinetheeneonataleperiod.
5. TheetwoemajorefunctionaleclasseseofeeffectoreTelymphocyteseare:
a. HelpereTelymphocyteseandecytotoxiceTelymphocytes
b. NaturalekillerecellseandecytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemoryeTecellseandeeffectoreTecells
d. Helperecellseandeantigen-presentingecells
e. CytotoxiceTelymphocyteseandetargetecells
ANS:e e A
Tecellsecanebeeclassifiedeintoeeffectoresubsetsethateperformedifferenteeffectorefunctions.eMosteef
fectoreTecellseareeeitherehelpereTelymphocytes,ewhicheenhanceetheeresponseseofeothereimmunee
cells,eincludingephagocyteseandeBecells,etoeinfections,eorecytotoxiceTelymphocytes,ewhichedire
ctlyekilleinfectedecells.eNaturalekillerecellseareenoteTelymphocytes.
Antigen-presentingecellseusuallyeareenoteTecells.eMemoryeTecellseareenoteeffectoreTecells.
6. Whicheofetheefollowingecelletypeseiserequiredeforealleadaptiveehumoraleimmuneeresponses?
a. Naturalekillerecells
b. Dendriticecells
c. CytolyticeTelymphocytes
d. Belymphocytes
e. HelpereTelymphocytes
ANS:e e D
Humoraleimmuneeresponseseareeantibody-
mediatedeimmuneeresponses,eandealleantibodieseareemadeebyeBelymphocyteseandenoeotherecelle
type.
PlusBay.Plus
Cellular and Molecular Immunology
Abul Abbas, Andrew Lichtman, and Shiv Pillai
10th Edition
e
PlusBay.Plus
,Table of Contents
e e
Chaptere01ePropertieseandeOvervieweofeImmuneeResponses 1
Chaptere02eCellseandeTissueseofetheeImmuneeSystem 3
Chaptere03eLeukocyteeCirculationeandeMigrationeIntoeTissues 6
Chaptere04eInnateeImmunity 10
Chaptere05eAntibodieseandeAntigens 17
Chaptere06eAntigenePresentationetoeTeLymphocyteseandetheeFunctionseofeMajor
HistocompatibilityeComplexeMolecules 20
Chaptere07eImmuneeReceptorseandeSignaleTransduction 27
Chaptere08eLymphocyteeDevelopmenteandeAntigeneReceptoreGeneeRearrangement 30
Chaptere09eActivationeofeTeLymphocytes 34
Chaptere10eDifferentiationeandeFunctionseofeCD4+eEffectoreTeCells 38
Chaptere11eDifferentiationeandeFunctionseofeCD8+eEffectoreTeCells 42
Chaptere12eBeCelleActivationeandeAntibodyeProduction 46
Chaptere13eEffectoreMechanismseofeHumoraleImmunity 52
Chaptere14eSpecializedeImmunityeateEpithelialeBarrierseandeineImmuneePrivilegedeTissues 56
Chaptere15eImmunologiceToleranceeandeAutoimmunity 62
Chaptere16eImmunityetoeMicrobes 67
Chaptere17eTransplantationeImmunology 72
Chaptere18eTumoreImmunology 77
Chaptere19eHypersensitivityeDisorders 81
Chaptere20eAllergy 86
Chaptere21ePrimaryeandeAcquiredeImmunodeficiencies 89
PlusBay.Plus
,Chapter 01: Properties and Overview of Immune Responses
e e e e e e e
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
e e e e e e e e e
MULTIPLEeCHOICE
1. Theeprincipalefunctioneofetheeimmuneesystemeis:
a. Defenseeagainstecancer
b. Repaireofeinjuredetissues
c. Defenseeagainstemicrobialeinfections
d. Preventioneofeinflammatoryediseases
e. Protectioneagainsteenvironmentaletoxins
ANS:e e C
Theeimmuneesystemehaseevolvedeinetheesettingeofeselectiveepressureseimposedebyemicrobialeinfec
tions.eAlthougheimmuneeresponsesetoecanceremayeoccur,etheeconceptethate“immunosurveillance”e
againstecancereiseaeprincipalefunctioneofetheeimmuneesystemeisecontroversial.eRepaireofeinjuredetis
suesemayebeeaesecondaryeconsequenceeofetheeimmuneeresponseseandeinflammation.eAlthoughethee
immuneesystemehaseregulatoryefeaturesethateareeneededetoepreventeexcessiveeinflammation,eprev
entioneofeinflammatoryediseaseseisenoteaeprimaryefunction.eTheeimmuneesystemecaneprotecteagain
stemicrobialetoxins,ebuteitegenerallyedoesenoteoffereprotectioneagainstetoxinseofenonbiologiceorigin
.
2. Whicheofetheefollowingeinfectiousediseasesewasepreventedebyetheefirstesuccessfulev
accination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:e e C
Ine1798,eEdwardeJennerereportedetheefirsteintentionalesuccessfulevaccination,ewhichewaseagain
stesmallpoxeineaeboy,eusingematerialefrometheecowpoxepustuleseofeaemilkmaid.eIne1980,esmallpo
xewasereportedetoebeeeradicatedeworldwideebyeaevaccinationeprogram.eEffectiveevaccineseagai
nstetetanusetoxin,erubellaevirus,eandepoliovirusewereedevelopedeinethee20thecenturyeandeareewid
elyeused.eThereeisenoeeffectiveevaccineeagainsteMycobacteriumetuberculosis.
3. Whicheofetheefollowingeiseaeuniqueepropertyeofetheeadaptiveeimmuneesystem?
a. Highlyediverseerepertoireeofespecificitieseforeantigens
b. Self-nonselfediscrimination
c. Recognitioneofemicrobialestructuresebyebothecell-associatedeandesolubleereceptors
d. Protectioneagainsteviraleinfections
e. Responsesethatehaveetheesameekineticseandemagnitudeeonerepeatedeexposureetoethees
ameemicrobe
ANS:e e A
PlusBay.Plus
, HighlyediverseerepertoireseofespecificitieseforeantigenseareefoundeonlyeineTeandeBelymphocytes
,ewhicheareetheecentralecellularecomponentseofetheeadaptiveeimmuneesystem.eBothetheeinnateean
detheeadaptiveeimmuneesystemseuseecell-
associatedeandesolubleereceptorsetoerecognizeemicrobes,edisplayesomeedegreeeofeself-
nonselfediscrimination,eandeprotecteagainsteviruses.eOnerepeatedeexposureetoetheesameemicrob
e,etheeadaptiveeimmuneeresponseebecomesemoreerapideandeofegreateremagnitude;ethiseisetheema
nifestationeofememory.
4. AntibodieseandeTelymphocyteseareetheerespectiveemediatorseofewhichetwoetypeseofei
mmunity?
a. Innateeandeadaptive
b. Passiveeandeactive
c. Specificeandenonspecific
d. Humoraleandecell-mediated
e. Adulteandeneonatal
ANS:e e D
BotheBeandeTelymphocyteseareeprincipalecomponentseofeadaptiveeimmunity.eBelymphocytesepr
oduceeantibodies,ewhicheareetheerecognitioneandeeffectoremoleculeseofehumoraleimmuneerespo
nsesetoeextracellularepathogens.eTecellserecognizeeandepromoteeeradicationeofeintracellularepath
ogenseinecell-
mediatedeimmunity.ePassiveeandeactiveeimmunityebothecanebeemediatedebyeeithereBeoreTelymph
ocytes.eSpecificeimmunityeiseanotheretermeforeadaptiveeimmunity.eBotheBeandeTelymphocytesep
articipateeineadulteadaptiveeimmunityebuteareestilledevelopingeinetheeneonataleperiod.
5. TheetwoemajorefunctionaleclasseseofeeffectoreTelymphocyteseare:
a. HelpereTelymphocyteseandecytotoxiceTelymphocytes
b. NaturalekillerecellseandecytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemoryeTecellseandeeffectoreTecells
d. Helperecellseandeantigen-presentingecells
e. CytotoxiceTelymphocyteseandetargetecells
ANS:e e A
Tecellsecanebeeclassifiedeintoeeffectoresubsetsethateperformedifferenteeffectorefunctions.eMosteef
fectoreTecellseareeeitherehelpereTelymphocytes,ewhicheenhanceetheeresponseseofeothereimmunee
cells,eincludingephagocyteseandeBecells,etoeinfections,eorecytotoxiceTelymphocytes,ewhichedire
ctlyekilleinfectedecells.eNaturalekillerecellseareenoteTelymphocytes.
Antigen-presentingecellseusuallyeareenoteTecells.eMemoryeTecellseareenoteeffectoreTecells.
6. Whicheofetheefollowingecelletypeseiserequiredeforealleadaptiveehumoraleimmuneeresponses?
a. Naturalekillerecells
b. Dendriticecells
c. CytolyticeTelymphocytes
d. Belymphocytes
e. HelpereTelymphocytes
ANS:e e D
Humoraleimmuneeresponseseareeantibody-
mediatedeimmuneeresponses,eandealleantibodieseareemadeebyeBelymphocyteseandenoeotherecelle
type.
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