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Bone Physiology – Structure, Remodeling, Fractures, and Calcium Regulation – Complete Review with Key Terms

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This document provides a detailed overview of bone physiology, including bone structure, the roles of osteocytes, osteoblasts, and osteoclasts, the process of bone remodeling, and calcium homeostasis via the endocrine system. It also includes classifications of fractures, healing stages, and common bone-related diseases such as osteoporosis and rickets. Ideal for anatomy, physiology, and medical students needing a complete reference for skeletal system function and pathology.

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Bone Physiology
Support, Storage, Blood Cell Production, Protection, and Movement ✔✔Bone Functions

Calcium Phosphate Ca3/PO4/2 ✔✔chemical in bone matrix with written name and symbol

2/3s of Bone Weight ✔✔fraction of bone weight due to calcium phosphate

Epiphysis ✔✔the expanded portions at each end

Diaphysis ✔✔central shaft of a long bone

Marrow (Medullary) Cavity ✔✔inside the diaphysis; contains bone marrow

Compact Bone ✔✔relatively solid bone tissue

Spongy Bone ✔✔resembles a network of bony rods or struts separated by spaces

Periosteum ✔✔outer surface of a bone; two layers: an outer (tough)--continuous with muscles
and joints/inner--epithelial cells

Endosteum ✔✔covers the spongy bone of the marrow cavity

Articular Cartilage ✔✔covers the ends of bones

Yellow Marrow ✔✔fat molecules/storage

Lacuna ✔✔open cavity spaces/ Cells are located in space

Lamellae ✔✔oriented parallel to the long axis of the central canal; spaces in between

Canaliculi ✔✔microscopic canals between the lacunae of ossified bone

Osteon ✔✔basic unit of structure of compact bone

Haversian Canal ✔✔central canal

, Trabeculae ✔✔rods or plates formed by lamellae

Osteocytes ✔✔(found in bony matrix) recycle calcium salts and assist in repairs

Osteoclasts ✔✔(found in pits in the bone surface known as resorption bays or Howship's
Lacunae) regulate calcium and phosphate concentrations

Osteoblasts ✔✔assist in the production of new bone

Bone Remodeling ✔✔the process where the skeleton is absorbed by the osteoclasts and
created by the osteoblasts; this cycle is continuous and bones are constantly recycled and
replaced

Support and Storage ✔✔bone functions dependent on bone remodeling

1/5 of Bone Calcium ✔✔proportion of bone calcium exchanged each year

Neurons and Muscle Cells ✔✔types of cells that calcium ions are most important to

Nervous Cell Signals, Muscle Cell Contraction, and Blood Clotting ✔✔appropriate blood
calcium levels are important for these three body physiological processes

Unresponsive Neurons and Muscle Cells ✔✔what occurs when calcium levels are too high

Convulsions or Death ✔✔what occurs when calcium levels are too low

Negative Feedback System ✔✔another name for the system dealing with calcium regulation

Thyroid Gland ✔✔If calcium levels are too high in the body fluids, the ______________
produces calcitonan, which causes increased excretion of calcium by kidneys, and calcium
deposition in bones, resulting in lower calcium levels.

Calcitonan ✔✔If calcium levels are too high in the body fluids, the thyroid gland produces
_____________, which causes increased excretion of calcium by kidneys, and calcium
deposition in bones, resulting in lower calcium levels.
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