NBME 28
1. Which sensory information is compromised by the unconscious propriocep-
anterior lobe of the superior cerebellum? tion
2. What controls conscious proprioception? DCML
3. Lesion in this part of the cerebellum can cause broad anterior lobe
based ataxia
4. Conscious proprioception, 2 point discrimination and vibration sense
_______ is also mediated by the DMCL
5. Synthesis of enzymes necessary for replication of G1 (because DNA gets du-
genome occurs in which phase of the cell cycle? plicated after in S phase)
6. Does proteins synthesis occur in M phase? no
7. This is the phase of cell where DNA replication occurs S phase
8. This is the phase where integrity of duplicated G2
genome is checked and corrected.
9. G2 phase is also where phase of growth and ________ protein
synthesis takes place in preparation for the phases of
mitosis and cell division
10. When looking at a serum [PAH] vs. PAH secretion rate lower
graph, there is an inflection point where secretion rate
plateaus, which means the clearance of PAH does not
increase (slope 0).
Before this inflection point, the clearance of PAH is
higher (slope >0).
, NBME 28
This means that on the plateau area, PAH clearance is
______ than it is in the ascending area.
11. What sequence encods the polyadenylation signal? AATAAA
12. Where do splice sites exist? At the end of an intron and
beginning of an exon
13. Mutations in the _____ region are known to cause beta promoter
thalassemia.
14. Capping with GTP occurs at the beginning of 5' end of the nascent
trasncription at the ________. mRNA
15. Capping with GTP at the 5' end of nascent mRNA is rec- ribosomes
ognized by ______ in cytoplasm and facilitates initation
of translation.
16. A mutation in GTP cap would result in synthesis of translation
normal mRNA transcript but failure of _________.
17. A 5 yr old girl has precocious puberty. Pelvic exam Granulosa
shows a mass consistent with ovarian tumor. Sstudies
show decreased gonadotropins and marked increase
in estrogens.
What is the ovarian tumor derived from most likely?
18. _____ tumors also produce estrogen and androgen thecal
like granulosa tumors and may present with post-
menopausal bleeding but are less common than gran-
ulosa tumors.
19.
, NBME 28
An old patient with fever, chills, tachycardia, hypoten- Excessive production of
sion and finally shock grows E. coli. nitric oxide
What is the most likely initial cause of the hypoten- Note that this is not
sion? caused by hemorrhage
because our patient's ab-
dominal pain is most likely
d/t infectious enteritis and
less likely from an abdom-
inal aortic aneurysm.
20. Ganciclovir is a guanosine analog that treats CMV and DNA polymerase
inhibits what?
21. Acyclovir, valacyclovir, and famciclovir treats HSV by thymidine kinase
inhibiting?
22. Is acyclovir used to treat CMV? No; because CMV does
not have thymidine kinase
23. Which muscle supinates the forearm? biceps brachii
24. Biceps brachii serves to supinate the forearm through proximal radius
its winding mechanism around the _________ _____ and
bicipital tuberosity
25. ________ _____ is a muscle of the proximal forearm that pronator teres
extends from the medial supracondylar ridge of the
humerus and inserts on the lateral aspect of the ra-
dius. It promotes pronation.
26. __________ originates on the medial epicondyle of the Flexor carpi radialis
humerus and inserts on the second/third MTC bones.
Allows for flexion of the wrist.
1. Which sensory information is compromised by the unconscious propriocep-
anterior lobe of the superior cerebellum? tion
2. What controls conscious proprioception? DCML
3. Lesion in this part of the cerebellum can cause broad anterior lobe
based ataxia
4. Conscious proprioception, 2 point discrimination and vibration sense
_______ is also mediated by the DMCL
5. Synthesis of enzymes necessary for replication of G1 (because DNA gets du-
genome occurs in which phase of the cell cycle? plicated after in S phase)
6. Does proteins synthesis occur in M phase? no
7. This is the phase of cell where DNA replication occurs S phase
8. This is the phase where integrity of duplicated G2
genome is checked and corrected.
9. G2 phase is also where phase of growth and ________ protein
synthesis takes place in preparation for the phases of
mitosis and cell division
10. When looking at a serum [PAH] vs. PAH secretion rate lower
graph, there is an inflection point where secretion rate
plateaus, which means the clearance of PAH does not
increase (slope 0).
Before this inflection point, the clearance of PAH is
higher (slope >0).
, NBME 28
This means that on the plateau area, PAH clearance is
______ than it is in the ascending area.
11. What sequence encods the polyadenylation signal? AATAAA
12. Where do splice sites exist? At the end of an intron and
beginning of an exon
13. Mutations in the _____ region are known to cause beta promoter
thalassemia.
14. Capping with GTP occurs at the beginning of 5' end of the nascent
trasncription at the ________. mRNA
15. Capping with GTP at the 5' end of nascent mRNA is rec- ribosomes
ognized by ______ in cytoplasm and facilitates initation
of translation.
16. A mutation in GTP cap would result in synthesis of translation
normal mRNA transcript but failure of _________.
17. A 5 yr old girl has precocious puberty. Pelvic exam Granulosa
shows a mass consistent with ovarian tumor. Sstudies
show decreased gonadotropins and marked increase
in estrogens.
What is the ovarian tumor derived from most likely?
18. _____ tumors also produce estrogen and androgen thecal
like granulosa tumors and may present with post-
menopausal bleeding but are less common than gran-
ulosa tumors.
19.
, NBME 28
An old patient with fever, chills, tachycardia, hypoten- Excessive production of
sion and finally shock grows E. coli. nitric oxide
What is the most likely initial cause of the hypoten- Note that this is not
sion? caused by hemorrhage
because our patient's ab-
dominal pain is most likely
d/t infectious enteritis and
less likely from an abdom-
inal aortic aneurysm.
20. Ganciclovir is a guanosine analog that treats CMV and DNA polymerase
inhibits what?
21. Acyclovir, valacyclovir, and famciclovir treats HSV by thymidine kinase
inhibiting?
22. Is acyclovir used to treat CMV? No; because CMV does
not have thymidine kinase
23. Which muscle supinates the forearm? biceps brachii
24. Biceps brachii serves to supinate the forearm through proximal radius
its winding mechanism around the _________ _____ and
bicipital tuberosity
25. ________ _____ is a muscle of the proximal forearm that pronator teres
extends from the medial supracondylar ridge of the
humerus and inserts on the lateral aspect of the ra-
dius. It promotes pronation.
26. __________ originates on the medial epicondyle of the Flexor carpi radialis
humerus and inserts on the second/third MTC bones.
Allows for flexion of the wrist.
