Summary Cholesterol Synthesis Pathway

i HMG COA 5-phospho-mevalonate
·
pyrophosphate
3-isopenty
--
CHy




iii Naropappo
openopos
CHy


I
O




notepos
x -

SCOA

ppi opo a


· pophate
3-isopentyl




3
>
-
mate
Geranyl pyrophosphate
HMG COA 5-phospho-mevalonate
pyrophosphate
3-isopenty




CP
Farnesyl pyrophosphate + NADPH




i
O I t 2 Hz
x

hap
-

SCOA




of NADot the




HMG COA
5-phospho-mevalonate pyrophosphate
3-isopenty
~
CHs 943

S -
iii
200
-




I t 2 Hz cHz

hap
↑

of
s
Kinate




HMG COA
pyrophosphate
3-isopenty

- squalene
5-phospho-mevalonate

CHy




i & Po
I t 2 Hz
Hopoopo
CHy




>
O




hap on

·top
x -

SCOA
,
opo a
3-isopentyl pyrophosphate
Kinate
-
-

5-phospho-mevalonate pyrophosphate
3-isopenty


Lob of




i
I t 2 Hz
steps
-




200
O




hap
x -

SCOA




Kinate
·
HMG COA 5-phospho-mevalonate pyrophosphate
3-isopenty




din
Chy




·
Cholesterd