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McCance & Huether’s Pathophysiology The Biologic Basis for Disease in Adults and
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Children 9th Edition by Julia Rogers
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Chapter 1-49 f
Chapter 01: Cellular Biology
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Rogers: McCance & Huether’s Pathophysiology, 9th Edition
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MULTIPLE CHOICE f
1. Which statement best describes the cellular function of metabolic absorption?
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a. Cells can produce proteins. f f f
b. Cells can secrete digestive enzymes. f f f f
c. Cells can take in and use nutrients. f f f f f f
d. Cells can synthesize fats. f f f
ANS: C f
In metabolic absorption, all cells take in and use nutrients and other substances from their
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surroundings. The remaining options are not inclusive in their descriptions of cellular
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metabolic absorption.
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DIF: Cognitive Level: Remembering f f
2. Where is most of a cell’s genetic information, including RNA and DNA, contained?
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a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS: C f
The nucleus contains the nucleolus, a small dense structure composed largely of RNA, most of
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the cellular DNA, and the DNA-binding proteins, such as the histones, which regulate its
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activity. The mitochondria are responsible for cellular respiration and energy production.
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Ribosomes’ chief function is to provide sites for cellular protein synthesis. Lysosomes function
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as the intracellular digestive system.
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DIF: Cognitive Level: Remembering f f
3. Which component of the cell produces hydrogen peroxide (H2O2) by using oxygen to remove
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hydrogen atoms from specific substrates in an oxidative reaction?
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a. Lysosomes
b. Peroxisomes
,c. Ribosomes
d. Endosome
ANS: B
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, Peroxisomes are so named because they usually contain enzymes that use oxygen to remove
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hydrogen atoms from specific substrates in an oxidative reaction that produces H2O2, which is a
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powerful oxidant and potentially destructive if it accumulates or escapes from peroxisomes.
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Ribosomes are RNA-protein complexes (nucleoproteins) that are synthesized in the nucleolus
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and secreted into the cytoplasm through pores in the nuclear envelope called nuclear pore
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complexes. Lysosomes are saclike structures that originate from the Golgi complex and contain
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more than 40 digestive enzymes called hydrolases, which catalyze bonds in proteins, lipids,
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nucleic acids, and carbohydrates. An endosome is a vesical that has been pinched off from the
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cellular membrane.
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DIF: Cognitive Level: Remembering f f
4. Which cell component is capable of cellular autodigestion when it is released during cell
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injury?
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a. Ribosome
b. Golgi complex f
c. Smooth endoplasmic reticulum f f
d. Lysosomes
ANS: D f
The lysosomal membrane acts as a protective shield between the powerful digestive enzymes
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within the lysosome and the cytoplasm, preventing their leakage into the cytoplasmic matrix.
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Disruption of the membrane by various treatments or cellular injury leads to a release of the
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lysosomal enzymes, which can then react with their specific substrates, causing cellular self-
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digestion. The chief function of a ribosome is to provide sites for cellular protein synthesis.
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The Golgi complex is a network of flattened, smooth vesicles and membranes often located
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near the cell nucleus. The smooth endoplasmic reticulum is involved in steroid hormone
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production and removing toxic substances from the cell.
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DIF: Cognitive Level: Remembering f f
5. Which cAMP-mediated response is related to antidiuretic hormone?
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a. Increased heart rate and force of contraction f f f f f f
b. Secretion of cortisol f f
c. Increased retention of water f f f
d. Breakdown of fat f f
ANS: C f
Antidiuretic hormone leads to increased retention of water in the body. Epinephrine causes
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increases in heart rate and force of contraction. Increased cortisol secretion is due to ACTH.
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Breakdown of fat is due to glucagon.
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DIF: Cognitive Level: Remembering f f
6. During which phase of the cell cycle is DNA synthesized?
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a. G1
b. S
c. G2
d. M
ANS: B f