MH 701 Final Exam Mine EXAM |
Questions and Answers | 100% Correct
(Latest Update )
1. What is a common mistake leading to unsuccessful
antidepressant drug trial?: Not giving it enough time and sub
therapeutic dosing .
2. Pharmacodynamics: what the drug does to the body; mechanism
of action
3. Pharmacokinetics: What the body does to the drug. The process
by which drugs are absorbed, distributed within the body,
metabolized, and excreted.
4. Inducers: speed up the metabolism (breakdown) of the drug,
thereby lowering serum levels/AUC
5. Inhibitors: slow down the metabolism of the drug, thereby
increasing serum levels/AUC
MH701
,6. Major depression is?: 5 or more of the following symptoms in the
same 2 week period with at least 1 being depressed mood or loss
of interest or pleasure.
SIGECAPS
S: Sleep changes.
I: interest loss.
G: Guilt or worthlessness.
E: Energy lack.
C: Concentration /cognition reduced.
A: Appetite usually declined.
P: Psychomotor retardation.
S: Suicidal or homicidal ideation.
7. Dysthymia is?: Persistent depressive symptoms lasting 2 years.
8. What role does serotonin have in the different aspects of
depression?: Serotonin regulates mood, sleep, appetite, pain,
sex, instincts.
Too much or too little can cause depression or apathy.
,9. Which neurotransmitters have been implicated in
depression?: Serotonin (SSRI's)
Norepinephrine (SNRI's, NDRIs)
Dopamine (NDRIs)
10. What education would you provide a patient about starting
any antidepressant medication: * Takes 2-6 weeks to see a
response
* Can increase suicidal ideation
* SE: sexual dysfunction, GI upset, activation, sedation, insomnia,
headaches * Serotonin syndrome -
* Do not abruptly stop medication, it must be slowly titrated down
15. What is serotonin syndrome?: Serotonin syndrome - abdominal
pain, diarrhea, flushing, diaphoresis, hyperthermia, mental status
changes. renal failure, rhabdomyolysis, cardiovascular shock, death
16. SSRIs for the treatment of bulimia to decrease binging
patterns?: Fluoxetine Prozac
, 17. Mechanism and action of SSRI:: - inhibit the reuptake of
serotonin, thereby increasing serotonin activity; have little effect on
other neurotransmitters, such as dopamine or norepinephrine
18. Mechanism and action of SNRI:: -inhibit the reuptake of the
neurotransmitters serotonin and norepinephrine, which increases
extracellular concentrations of serotonin and norepinephrine and,
consequently, an increase in neurotransmission. 19. Discontinuation
syndrome: Risk factors:: * Extended therapy of SSRI
* Paroxetine bigger offender follow by Venlafaxine, then sertraline,
citalopram, escitalopram
* Fluoxetine less likely to occur due to long half life
* Taper over several weeks to minimize discontinuation symptoms
20. Discontinuation syndrome symptoms: flu-like symptoms, fatigue
& lethargy, weakness, decreased concentration, N/V, impaired
memory, shock-like sensations aka "brain-zaps", acute return of
major depressive episode, return of anxiety if that's what was being
treated, irritability, anxiety, insomnia, crying w/o provocation,
dizziness & vertigo
Questions and Answers | 100% Correct
(Latest Update )
1. What is a common mistake leading to unsuccessful
antidepressant drug trial?: Not giving it enough time and sub
therapeutic dosing .
2. Pharmacodynamics: what the drug does to the body; mechanism
of action
3. Pharmacokinetics: What the body does to the drug. The process
by which drugs are absorbed, distributed within the body,
metabolized, and excreted.
4. Inducers: speed up the metabolism (breakdown) of the drug,
thereby lowering serum levels/AUC
5. Inhibitors: slow down the metabolism of the drug, thereby
increasing serum levels/AUC
MH701
,6. Major depression is?: 5 or more of the following symptoms in the
same 2 week period with at least 1 being depressed mood or loss
of interest or pleasure.
SIGECAPS
S: Sleep changes.
I: interest loss.
G: Guilt or worthlessness.
E: Energy lack.
C: Concentration /cognition reduced.
A: Appetite usually declined.
P: Psychomotor retardation.
S: Suicidal or homicidal ideation.
7. Dysthymia is?: Persistent depressive symptoms lasting 2 years.
8. What role does serotonin have in the different aspects of
depression?: Serotonin regulates mood, sleep, appetite, pain,
sex, instincts.
Too much or too little can cause depression or apathy.
,9. Which neurotransmitters have been implicated in
depression?: Serotonin (SSRI's)
Norepinephrine (SNRI's, NDRIs)
Dopamine (NDRIs)
10. What education would you provide a patient about starting
any antidepressant medication: * Takes 2-6 weeks to see a
response
* Can increase suicidal ideation
* SE: sexual dysfunction, GI upset, activation, sedation, insomnia,
headaches * Serotonin syndrome -
* Do not abruptly stop medication, it must be slowly titrated down
15. What is serotonin syndrome?: Serotonin syndrome - abdominal
pain, diarrhea, flushing, diaphoresis, hyperthermia, mental status
changes. renal failure, rhabdomyolysis, cardiovascular shock, death
16. SSRIs for the treatment of bulimia to decrease binging
patterns?: Fluoxetine Prozac
, 17. Mechanism and action of SSRI:: - inhibit the reuptake of
serotonin, thereby increasing serotonin activity; have little effect on
other neurotransmitters, such as dopamine or norepinephrine
18. Mechanism and action of SNRI:: -inhibit the reuptake of the
neurotransmitters serotonin and norepinephrine, which increases
extracellular concentrations of serotonin and norepinephrine and,
consequently, an increase in neurotransmission. 19. Discontinuation
syndrome: Risk factors:: * Extended therapy of SSRI
* Paroxetine bigger offender follow by Venlafaxine, then sertraline,
citalopram, escitalopram
* Fluoxetine less likely to occur due to long half life
* Taper over several weeks to minimize discontinuation symptoms
20. Discontinuation syndrome symptoms: flu-like symptoms, fatigue
& lethargy, weakness, decreased concentration, N/V, impaired
memory, shock-like sensations aka "brain-zaps", acute return of
major depressive episode, return of anxiety if that's what was being
treated, irritability, anxiety, insomnia, crying w/o provocation,
dizziness & vertigo
