N6308 Peds Oncology| QUESTIONS WITH 100% CORRECT ANSWERS| LATEST UPDATE
100% VERIFIED
Why is it important to check the nasal discharge of someone who is post-op brain tumor
resection? to distinguish mucus from CSF
How can you distinguish mucus from CSF? use a chem strip to test the discharge and look
for presence of glucose
The presence of glucose in nasal discharge indicates that the fluid is: CSF
What is the most common malignant extracranial solid tumor of childhood? neuroblastoma
True or false: a neuroblastoma is a type of brain tumor. false: a neuroblastoma is an
extracranial tumor
True or false: neuroblastomas have a genetic component. true
50% of all neuroblastoma cases occur in children under what age? 2 yrs
True or false: neuroblastoma prognosis is best in children over 2 yrs of age. false: best under
2 yrs
Children with neuroblastomas under what age may experience spontaneous remission? 1
yrs
Are neuroblastomas more common in males or females? males
,Neuroblastomas have an increased prevalence in what race? white children
What percentage of neuroblastoma patients over age 2 yrs present with metastasis symptom in
non-primary sites? 80%
True or false: the majority of neuroblastoma patients over age 2 present with metastasis to
non-primary sites. true
What are some of the common metastasis sites for neuroblastomas? -lymph nodes
-bone marrow
-skin
-liver
-skeletal system
Describe the pathophysiology of a neuroblastoma. originates from neural crest cells, which
normally develop into sympathetic nervous system and adrenal medulla
Neuroblastomas originate from what type of cells? neural crest cells
What are the 2 most common sites for neuroblastoma development? -adrenal gland
-retroperitoneal sympathetic chain (at base of spine)
Most neuroblastoma cels have genetic abnormalities involving which chromosome?
chromosome 1 (deletion or rearrangement on short arm)
,In neuroblastomas, the chromosome 1 abnormalities causes the amplification of which
oncogene? MYCN
In neuroblastomas, amplification of oncogene MYCN causes: uncontrolled cell growth
As many as 20% of neuroblastoma cases result from: inherited mutation, followed by a
second mutation occurring after birth
True or false: neuroblastomas are linked to environmental factors. false: because the tumor
occurs very early in childhood, it is doubtful that any environmental exposures the child has
incurred could be linked to the development of the tumor
What are some of the clinical manifestations of neuroblastomas? -abdominal pass
-protuberant, firm abdomen
-weight loss
-loss of appetite
-impaired ROM and mobility
-pain and limping
-impaired bowel and bladder function
-inability to walk
-fever
-hypertension
What are some of the specific neuroblastoma symptoms associated with the respiratory
system? -cough
-respiratory compromise
, What are some of the specific neuroblastoma symptoms associated with the face/neck? -
facial, periorbital edema
-bruising
-raccoon eyes
Raccoon eyes are a characteristic symptom associated with what type of tumor?
neuroblastoma
Why do so many children with neuroblastomas present with raccoon eyes? related to the
obstruction of palpebral vessels in face by tumor tissue in/around orbits
MIBG scans are used specifically to detect what type of tumor? neuroblastoma
What is the name of the scan used to detect a neuroblastoma? MIBG scan
(metaiodobenzylguanidine)
What is a MIBG scan? nuclear imagine test to identify where and to what extent the
neuroblastoma tumor has spread through the body
What is MIGB? radioactive substance that attaches to neuroblastoma cells
How does a MIBG scan work to detect neuroblastomas? -MIBG given IV
-body scan done 24h after administration to allow for radioactive medicine in injection to mix
with blood specific for spread of neuroblastoma
A diagnosis of neuroblastoma may be indicated by urinary excretion of: catecholamines
100% VERIFIED
Why is it important to check the nasal discharge of someone who is post-op brain tumor
resection? to distinguish mucus from CSF
How can you distinguish mucus from CSF? use a chem strip to test the discharge and look
for presence of glucose
The presence of glucose in nasal discharge indicates that the fluid is: CSF
What is the most common malignant extracranial solid tumor of childhood? neuroblastoma
True or false: a neuroblastoma is a type of brain tumor. false: a neuroblastoma is an
extracranial tumor
True or false: neuroblastomas have a genetic component. true
50% of all neuroblastoma cases occur in children under what age? 2 yrs
True or false: neuroblastoma prognosis is best in children over 2 yrs of age. false: best under
2 yrs
Children with neuroblastomas under what age may experience spontaneous remission? 1
yrs
Are neuroblastomas more common in males or females? males
,Neuroblastomas have an increased prevalence in what race? white children
What percentage of neuroblastoma patients over age 2 yrs present with metastasis symptom in
non-primary sites? 80%
True or false: the majority of neuroblastoma patients over age 2 present with metastasis to
non-primary sites. true
What are some of the common metastasis sites for neuroblastomas? -lymph nodes
-bone marrow
-skin
-liver
-skeletal system
Describe the pathophysiology of a neuroblastoma. originates from neural crest cells, which
normally develop into sympathetic nervous system and adrenal medulla
Neuroblastomas originate from what type of cells? neural crest cells
What are the 2 most common sites for neuroblastoma development? -adrenal gland
-retroperitoneal sympathetic chain (at base of spine)
Most neuroblastoma cels have genetic abnormalities involving which chromosome?
chromosome 1 (deletion or rearrangement on short arm)
,In neuroblastomas, the chromosome 1 abnormalities causes the amplification of which
oncogene? MYCN
In neuroblastomas, amplification of oncogene MYCN causes: uncontrolled cell growth
As many as 20% of neuroblastoma cases result from: inherited mutation, followed by a
second mutation occurring after birth
True or false: neuroblastomas are linked to environmental factors. false: because the tumor
occurs very early in childhood, it is doubtful that any environmental exposures the child has
incurred could be linked to the development of the tumor
What are some of the clinical manifestations of neuroblastomas? -abdominal pass
-protuberant, firm abdomen
-weight loss
-loss of appetite
-impaired ROM and mobility
-pain and limping
-impaired bowel and bladder function
-inability to walk
-fever
-hypertension
What are some of the specific neuroblastoma symptoms associated with the respiratory
system? -cough
-respiratory compromise
, What are some of the specific neuroblastoma symptoms associated with the face/neck? -
facial, periorbital edema
-bruising
-raccoon eyes
Raccoon eyes are a characteristic symptom associated with what type of tumor?
neuroblastoma
Why do so many children with neuroblastomas present with raccoon eyes? related to the
obstruction of palpebral vessels in face by tumor tissue in/around orbits
MIBG scans are used specifically to detect what type of tumor? neuroblastoma
What is the name of the scan used to detect a neuroblastoma? MIBG scan
(metaiodobenzylguanidine)
What is a MIBG scan? nuclear imagine test to identify where and to what extent the
neuroblastoma tumor has spread through the body
What is MIGB? radioactive substance that attaches to neuroblastoma cells
How does a MIBG scan work to detect neuroblastomas? -MIBG given IV
-body scan done 24h after administration to allow for radioactive medicine in injection to mix
with blood specific for spread of neuroblastoma
A diagnosis of neuroblastoma may be indicated by urinary excretion of: catecholamines
